Article
Immunology
Olof Nibell, Henrik Svanstrom, Malin Inghammar
Summary: This study found that fluoroquinolone treatment is associated with an increased risk of acute liver injury in the first two months after starting the treatment.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Cell Biology
Daisuke Ito, Hiroyasu Ito, Takayasu Ideta, Ayumu Kanbe, Soranobu Ninomiya, Masahito Shimizu
Summary: The study demonstrates that treatment with SPD can accelerate skin wound healing through activation of the uPA/uPAR pathway and induction of the inflammatory response at wound sites. The results suggest that SPD administration may offer new effective treatments to promote skin wound repair.
CELL COMMUNICATION AND SIGNALING
(2021)
Article
Plant Sciences
Milene Conceicao de Souza, Jhones Trindade Hubner, Gabriela Mastrangelo Goncalves, Thayane Ferreira da Costa Fernandes, Roberto Laureano-Melo, Wellington da Silva Cortes, Lenicio Goncalves, Francisco de Assis da Silva, Bruno Guimaraes Marinho
Summary: The seed oil of Joannesia princeps demonstrated effective pharmacological activity against acute pain and inflammation through both systemic and topical administration, reducing inflammatory responses and leukocyte recruitment, as well as decreasing the production of cytokines.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Cell & Tissue Engineering
Dagmara Grot, Katarzyna Wasiak, Jerzy Tyszkowski, Ewelina Stoczynska-Fidelus, Tomasz P. Ochedalski, Piotr Rieske
Summary: The etiopathogenesis of fluoroquinolone-associated disability (FQAD) syndrome is not fully understood, but utilizing induced pluripotent stem cells (iPSc) from individuals with FQAD could advance research and provide potential therapy. However, the success rate of converting urinary cells from FQAD patients into iPSc is low, suggesting limitations in their regeneration system.
STEM CELL RESEARCH & THERAPY
(2022)
Review
Pharmacology & Pharmacy
Taku Fujimura, Ryo Amagai, Yumi Kambayashi, Setsuya Aiba
Summary: This review evaluates the available therapeutic options for early- and advanced-stage CTCL in clinical practice, as well as the ongoing clinical trials for novel regimens in the treatment of CTCL.
Article
Ophthalmology
Yohei Hashimoto, Nobuaki Michihata, Hayato Yamana, Daisuke Shigemi, Kojiro Morita, Hiroki Matsui, Hideo Yasunaga, Makoto Aihara
Summary: The study found that exposure to topical ophthalmic antibiotics during pregnancy was not significantly associated with adverse neonatal outcomes.
Review
Nutrition & Dietetics
Paolo Fogagnolo, Stefano De Cilla', Micol Alkabes, Pierfilippo Sabella, Luca Rossetti
Summary: Vitamins play a critical role in regulating inflammation and promoting cell differentiation on the ocular surface. Vitamin A and D supplementation have shown effectiveness in treating OSD and DED, with improvements in both signs and symptoms. Further research is needed to determine the efficacy of supplementation with other vitamins.
Review
Infectious Diseases
Audray St-Jean, Dan Chateau, Matthew Dahl, Pierre Ernst, Nick Daneman, Ingrid S. Sketris, Jianguo Zhang, Fawziah Marra, Jacqueline Quail, Shawn Bugden
Summary: Fluoroquinolones are commonly used as first-line therapies for uncomplicated UTI and AECOPD in outpatient settings in Canada, but their use varies widely across provinces. The proportion of fluoroquinolones for treating uncomplicated UTI and ABS events has declined over time, while remaining relatively stable for AECOPD.
BMC INFECTIOUS DISEASES
(2021)
Article
Environmental Sciences
Rafael Shinji Akiyama Kitamura, Tayna Fusaro, Raizza Zorman Marques, Julio Cesar Moreira Brito, Philippe Juneau, Marcelo Pedrosa Gomes
Summary: Macrophytes have the potential to remove pharmaceuticals from water, but the ecotoxicity of water after phytoremediation is not well-studied. This study evaluated the toxicity of Cipro on microalgae cells exposed to water contaminated with Cipro and treated by Salvinia molesta or Egeria densa. Microalgae exposed to Cipro in untreated water showed decreased rates of growth, respiration, and photosynthesis, as well as increased oxidative status and damages. S. molesta exhibited better phytoremediation capacity than E. densa, reducing Cipro concentrations in water to below toxic levels.
Article
Chemistry, Analytical
Elena Megias-Perez, Javier Gimenez-Lopez, Arena Lascorz, Barbara Benedetti, Cristina Minguillon, Dolores Barron
Summary: The aim of this study was to develop selective extraction materials for a variety of fluoroquinolones. A series of Molecularly Imprinted Materials (MIPs) were prepared and evaluated for their selectivity in the extraction of enrofloxacin. The optimized composition was then upgraded to magnetic molecularly imprinted polymers (MMIPs) for the analysis of fluoroquinolones in milk. The selectivity of the MMIP for several fluoroquinolones was studied, and its applicability was tested against real quinolone positive milk samples.
MICROCHEMICAL JOURNAL
(2023)
Article
Medical Informatics
Sunah Song, Brigid M. Wilson, Joseph Marek, Robin L. P. Jump
Summary: This study demonstrates the use of pharmacy invoice data as a viable source for tracking and reporting antibiotic use in nursing homes. By aggregating and cleaning the data, various antibiotic use metrics were assessed and an interactive website was created for further analysis, providing a useful approach for nursing homes to develop antibiotic stewardship programs.
BMC MEDICAL INFORMATICS AND DECISION MAKING
(2021)
Review
Medicine, General & Internal
Lee-Yee Chong, Karen Head, Katie E. Webster, Jessica Daw, Peter Richmond, Tom Snelling, Mahmood F. Bhutta, Anne Gm Schilder, Martin J. Burton, Christopher G. Brennan-Jones
Summary: Chronic suppurative otitis media (CSOM) is characterized by chronic inflammation and polymicrobial infection of the middle ear, with ear discharge and hearing loss as predominant symptoms. Antibiotics are the main treatment for CSOM, with topical administration potentially more effective in resolving ear discharge compared to systemic administration. However, the quality of evidence is low, and more research is needed to determine the effectiveness of different types of antibiotics in treating CSOM.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2021)
Article
Infectious Diseases
Gabriele Gradl, Johanna Werning, Salka Enners, Marita Kieble, Martin Schulz
Summary: The study demonstrated regional quality differences in the use of oral cephalosporins and fluoroquinolones in Germany from 2014 to 2019. Usage varied between federal states, with higher quality indicators observed in city-states like Hamburg, Bremen, and Berlin. A significant decrease in oral cephalosporin utilization was found across all states from 2014-2019, along with a decline in fluoroquinolone use from 2017-2019.
Review
Pharmacology & Pharmacy
Shanna C. Yeung, Jamie Y. Park, Daniel Park, Yuyi You, Peng Yan
Summary: This review summarizes the associations between systemic and topical medications and changes in choroidal thickness, finding that IOP-lowering therapies, atropine eye drops, systemic administration of beta blockers, and ethanol are associated with an increase in CT, while cyclopentolate and phenylephrine are associated with a decrease in CT. Further research on the choroid and its response to different disease processes and medications is needed to improve patient care.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2022)
Review
Microbiology
Dalibor Mijaljica, Fabrizio Spada, Ian P. Harrison
Summary: Topical antifungal formulations containing miconazole or terbinafine are commonly used for treating fungal skin infections. They have specific mechanisms of action and can target the infection site, enhance treatment efficacy, and reduce systemic side effects. However, inflammation and itchiness can hinder treatment, and a combination of antifungal-corticosteroid formulations can help alleviate inflammation, relieve itchiness, and treat the fungal infection effectively.
