Article
Obstetrics & Gynecology
Stephen Contag, Rahel Nardos, Irina A. Buhimschi, Jennifer Almanza
Summary: A study in Minnesota found that Somali women have longer gestational ages at delivery compared to other ethnic groups, resulting in higher risks for stillbirth and neonatal death rates. However, at 42 weeks, Somali neonatal mortality decreased and was comparable to that of the U.S. born White population, and lower than that of other minorities.
BMC PREGNANCY AND CHILDBIRTH
(2021)
Review
Radiology, Nuclear Medicine & Medical Imaging
G. Masselli, D. Cozzi, S. Ceccanti, F. Laghi, A. Giancotti, R. Brunelli
Summary: Fetal magnetic resonance imaging (MRI) is a valuable tool in diagnosing fetal abnormalities and can assist parents in making informed decisions during the perinatal period. An advanced fetal MRI protocol led by experts in maternal-fetal medicine emphasizes patient-centered care and maximizes treatment options.
CLINICAL RADIOLOGY
(2021)
Article
Engineering, Civil
Michael A. Ainslie, Michele B. Halvorsen, Stephen P. Robinson
Summary: Applications of underwater acoustics are diverse, but the lack of clear terminology communication often leads to interdisciplinary misunderstandings. The international standard ISO 18405 provides precise definitions for acoustic terms, facilitating effective communication of concepts and information in underwater acoustics.
IEEE JOURNAL OF OCEANIC ENGINEERING
(2022)
Article
Immunology
Caitriona Murphy, William B. MacLeod, Leah S. Forman, Lawrence Mwananyanda, Geoffrey Kwenda, Rachel C. Pieciak, Zachariah Mupila, Donald Thea, Chilufya Chikoti, Baron Yankonde, Bernard Ngoma, Charles Chimoga, Christopher J. Gill
Summary: This study found that RSV is a significant contributor to community respiratory deaths in Lusaka, Zambia, especially in the first 3 months of life and in the more poor and dense parts of the city.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Pediatrics
Rotem Lapidot, Anna Larson Williams, William B. MacLeod, Magdalene Mwale, Ronke Olowojesiku, Andrew Enslen, Lawrence Mwananyanda, Gertrud Munanjala, Charles Chimoga, Benard Ngoma, Donald L. Thea, Christopher John Gill
Summary: The study reveals that infant mortality in Zambia is associated with delays and barriers in care, with many infants who are brought in dead experiencing multiple delays. The main delay observed is the family's decision to seek care, with many infants dying en route to healthcare facilities or while waiting for care.
Article
Public, Environmental & Occupational Health
Julie L. Ware, Ruowei Li, Aimin Chen, Jennifer M. Nelson, Jennifer M. Kmet, Sharyn E. Parks, Ardythe L. Morrow, Jian Chen, Cria G. Perrine
Summary: This study analyzed the association between initiation of breastfeeding and post-perinatal infant mortality at the state and regional levels in the United States. The results showed that all seven U.S. geographic regions had significant reductions in postperinatal infant deaths associated with breastfeeding initiation. The Mid-Atlantic and Northeast regions had the largest reductions, while the Southeast had the smallest reduction.
AMERICAN JOURNAL OF PREVENTIVE MEDICINE
(2023)
Article
Pediatrics
Neamin Tesfay, Frehiwot Legesse, Mandefro Kebede, Fitsum Woldeyohannes
Summary: This study identifies potential factors related to stillbirth in Ethiopia based on nationally reviewed perinatal deaths. Individual factors such as place of delivery, cause of death, maternal health condition, and maternal education, as well as facility-level factors such as type of health facility and delay in receiving adequate care, are associated with the risk of stillbirth.
FRONTIERS IN PEDIATRICS
(2022)
Article
Medicine, General & Internal
Chiara Lubrano, Emanuela Taricco, Chiara Coco, Fiorenza Di Domenico, Chiara Mando, Irene Cetin
Summary: Alterations in intrauterine fetal growth increase the risk of adverse perinatal and neonatal outcomes. Risk factors for fetal growth alterations include advanced age, being primiparous, and a lower pregestational BMI. Prematurity, hyperlactacidemia, and hypoxemia are the main factors contributing to worse neonatal outcomes.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Pediatrics
Olachi J. Mezu-Ndubuisi, Akhil Maheshwari
Summary: This article reviews the roles of fetal and neonatal macrophages in immune surveillance, innate immunity, tissue remodeling, angiogenesis, and tissue repair. Macrophages in the neonatal period are derived from embryonic, hepatic, and bone marrow precursors and play crucial roles in maintaining tissue homeostasis, immune responses, inflammation, and repair processes in various diseases. The manipulation of macrophage subsets may hold therapeutic potential in treating neonatal diseases.
PEDIATRIC RESEARCH
(2021)
Article
Public, Environmental & Occupational Health
Ivete Maria Kreutz, Ina S. Santos
Summary: This study aimed to describe the preventable infant mortality rate in Rio Grande do Sul, Brazil. The results showed that the strategies to reduce preventable infant deaths should focus on preventing prematurity and providing adequate care during pregnancy.
Article
Acoustics
S. K. Y. Choi, A. Gordon, L. Hilder, A. Henry, J. A. Hyett, B. K. Brew, F. Joseph, L. Jorm, G. M. Chambers
Summary: This study evaluated the performance of different birth-weight and estimated-fetal-weight standards in classifying fetuses and predicting perinatal outcomes. Results showed variations in the applicability of these standards to the Australian population, raising questions about the universal adoption of international standards.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2021)
Article
Medicine, General & Internal
Natasha Housseine, Marcus J. Rijken, Katinka Weller, Nassra Haroub Nassor, Kayode Gbenga, Caitlin Dodd, Thomas Debray, Tarek Meguid, Arie Franx, Diederick E. Grobbee, Joyce L. Browne
Summary: This study aimed to develop a prognostic model for identifying women at risk of intrapartum-related perinatal deaths in low-resourced settings. The authors externally validated an existing prediction model and developed a new model, finding that the new model performed well in predicting the risk of perinatal death in women admitted in labor wards.
Article
Radiology, Nuclear Medicine & Medical Imaging
Aviad Rabinowich, Netanell Avisdris, Bossmat Yehuda, Ayala Zilberman, Tamir Graziani, Bar Neeman, Bella Specktor-Fadida, Dafna Link-Sourani, Yair Wexler, Jacky Herzlich, Karina Krajden Haratz, Leo Joskowicz, Liat Ben Sira, Liran Hiersch, Dafna Ben Bashat
Summary: Smaller, leaner fetuses are malnourished and will experience unfavorable outcomes.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Pediatrics
Mikael Norman, David Nilsson, Johan Trygg, Stellan Hakansson
Summary: This study assessed the strength of associations between perinatal risk factors and mortality in very preterm infants. The results showed that Apgar scores, gestational age, and birthweight were more strongly associated with mortality than other available perinatal risk factors at birth.
Review
Multidisciplinary Sciences
Neamin Tesfay, Rozina Tariku, Alemu Zenebe, Girmay Hailu, Muse Taddese, Fitsum Woldeyohannes
Summary: This study aimed to determine the magnitude and risk factors associated with the timing of perinatal death in Ethiopia. The study used national perinatal death surveillance data, and found that the majority of perinatal deaths occurred during the neonatal period. Various factors at the individual and provincial level were associated with the timing of perinatal death. The study also observed significant inter-regional variation in the timing of perinatal death.
Article
Microbiology
Jumana Samara, Shirin Moossavi, Belal Alshaikh, Van A. Ortega, Veronika Kucharova Pettersen, Tahsin Ferdous, Suzie L. Hoops, Amuchou Soraisham, Joseph Vayalumkal, Deonne Dersch-Mills, Jeffrey S. Gerber, Sagori Mukhopadhyay, Karen Puopolo, Thomas A. Tompkins, Dan Knights, Jens Walter, Harish Amin, Marie-Claire Arrieta
Summary: Probiotics have positive effects on gut microbiome assembly and immunity in premature infants, accelerating microbiome maturation and improving intestinal immune environment.
CELL HOST & MICROBE
(2022)
Article
Immunology
Karen M. Puopolo, Sagori Mukhopadhyay, Nellie Hansen, Dustin D. Flannery, Rachel G. Greenberg, Pablo J. Sanchez, Edward F. Bell, Sara B. DeMauro, Myra H. Wyckoff, Eric C. Eichenwald, Barbara J. Stoll
Summary: This study found that the incidence of GBS disease did not change significantly among extremely preterm infants during the study period. Infants with GBS early-onset disease had a higher risk of death or neurodevelopmental impairment compared to those with other infections or uninfected infants. GBS late-onset disease did not have a significant impact on the risk of death or NDI.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Obstetrics & Gynecology
Dustin D. Flannery, Molly Passarella, Sagori Mukhopadhyay, Miren B. Dhudasia, Jeffrey S. Gerber, Scott A. Lorch, Sean Hennessy, Karen M. Puopolo
Summary: This study found that infants discharged from the NICU had a higher antibiotic utilization rate in early childhood compared to non-NICU infants.
JOURNAL OF PERINATOLOGY
(2022)
Article
Obstetrics & Gynecology
Heather H. Burris, Anne M. Mullin, Miren B. Dhudasia, Dustin D. Flannery, Sagori Mukhopadhyay, Madeline R. Pfeifer, Emily C. Woodford, Sara M. Briker, Jourdan E. Triebwasser, Jeffrey S. Morris, Diana Montoya-Williams, Sigrid Gouma, Scott E. Hensley, Karen M. Puopolo
Summary: Neighborhood deprivation and crowding were found to be associated with SARS-CoV-2 seropositivity in pregnant women, while segregation was not. Crowded housing may explain 10.2% of the disparity between Black and White individuals, while neighborhood deprivation may explain 6.7% of the disparity between Hispanic and White individuals.
OBSTETRICS AND GYNECOLOGY
(2022)
Letter
Obstetrics & Gynecology
Jourdan E. Triebwasser, Miren B. Dhudasia, Sagori Mukhopadhyay, Dustin D. Flannery, Sigrid Gouma, Scott E. Hensley, Karen M. Puopolo
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Article
Obstetrics & Gynecology
Dustin D. Flannery, Alvaro Zevallos Barboza, Madeline R. Pfeifer, Mark L. Hudak, Kimberly Barnette, Trace R. Getzlaff, Sascha R. Ellington, Kate R. Woodworth, Miren B. Dhudasia, Sagori Mukhopadhyay, Danielle D. Weinberg, Elizabeth E. Foglia, Karen M. Puopolo
Summary: This study describes the 1-month outcomes of newborns born to persons with perinatal COVID-19. The results showed that symptomatic pregnant persons were more likely to have a preterm delivery and their newborns were more likely to test positive for SARS-CoV-2. However, none of the newborns tested positive for SARS-CoV-2 within 1 month after discharge.
JOURNAL OF PERINATOLOGY
(2022)
Review
Obstetrics & Gynecology
Dustin D. Flannery, Karen M. Puopolo, Nellie Hansen, Pablo J. Sanchez, Barbara J. Stoll
Summary: The Neonatal Research Network (NRN) has conducted studies on the epidemiology of neonatal infections, providing critical data for national guidance and research into optimal approaches to infection diagnosis and treatment.
SEMINARS IN PERINATOLOGY
(2022)
Article
Immunology
Sagori Mukhopadhyay, Hannah L. Itell, Erica Hartman, Emily Woodford, Miren B. Dhudasia, Justin T. Steppe, Sarah Valencia, Hunter Roark, Kelly C. Wade, Kristin E. D. Weimer, Sallie R. Permar, Karen M. Puopolo
Summary: This study aimed to find a convenient screening method for managing pCMV in VLBW infants. The results showed that maternal breast milk can serve as a reliable alternative sample to determine CMV serostatus, while serial testing of infant saliva was not adequately sensitive for identifying pCMV acquisition in preterm infants.
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2022)
Letter
Medicine, General & Internal
Dustin D. Flannery, Alvaro Zevallos Barboza, Kelly C. Wade, Madeline R. Pfeifer, Jeffrey S. Gerber, Jeffrey S. Morris, Karen M. Puopolo
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Article
Pediatrics
Miren B. Dhudasia, William E. Benitz, Dustin D. Flannery, Lori Christ, David Rub, Giulia Remaschi, Karen M. Puopolo, Sagori Mukhopadhyay
Summary: This retrospective cohort study compared the impact of using and not using C-reactive protein (CRP) on the diagnosis of early-onset sepsis. The results showed that CRP had low sensitivity and specificity in diagnosing early-onset sepsis, making it unsuitable as a decision-making indicator. Not using CRP did not significantly affect patient outcomes.
JOURNAL OF PEDIATRICS
(2023)
Article
Immunology
Sarah A. Coggins, Erika M. Edwards, Dustin D. Flannery, Jeffrey S. Gerber, Jeffrey D. Horbar, Karen M. Puopolo
Summary: This study describes late-onset Serratia infection in very preterm infants. Serratia infection is associated with lower survival rate and significant morbidity, highlighting the need for recognition and targeted prevention strategies for this opportunistic nosocomial infection.
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2023)
Article
Pediatrics
Mark L. Hudak, Dustin D. Flannery, Kimberly Barnette, Trace Getzlaff, Shiva Gautam, Miren B. Dhudasia, Sagori Mukhopadhyay, Madeline R. Pfeifer, Sascha R. Ellington, Romeo R. Galang, Margaret C. Snead, Kate R. Woodworth, Lauren B. Zapata, Karen M. Puopolo
Summary: The American Academy of Pediatrics National Registry for the Surveillance and Epidemiology of Perinatal coronavirus disease 2019 (COVID-19) (NPC-19) was developed to provide information on the effects of perinatal severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. The study found that early in the pandemic, newborns acquired SARS-CoV-2 infection at variable rates and without apparent short-term effects. Additionally, higher than expected numbers of preterm births and maternal in-hospital deaths were observed.
Article
Pediatrics
Dustin D. Flannery, Erika M. Edwards, Sarah A. Coggins, Jeffrey D. Horbar, Karen M. Puopolo
Summary: This study examines the epidemiology, microbiology, and outcomes of late-onset sepsis among very preterm infants in the United States. The findings reveal a significant proportion of infants suffering from late-onset sepsis, particularly those born at the lowest gestational ages. Infected infants have higher mortality rates and survivors are at increased risk of technology-dependent chronic morbidities.
Article
Medicine, General & Internal
Dustin D. Flannery, Sigrid Gouma, Miren B. Dhudasia, Sagori Mukhopadhyay, Madeline R. Pfeifer, Emily C. Woodford, Sara M. Briker, Jourdan E. Triebwasser, Jeffrey S. Gerber, Jeffrey S. Morris, Madison E. Weirick, Christopher M. McAllister, Scott E. Hensley, Karen M. Puopolo
Summary: This study found that maternal and cord blood IgG antibody levels were higher after COVID-19 vaccination compared with after SARS-CoV-2 infection, with slightly lower placental transfer ratios after vaccination than after infection. The findings suggest that time from infection or vaccination to delivery was the most important factor in transfer efficiency.
Article
Pediatrics
Margo A. Sidell, Darios Getahun, Sara Y. Tartof, Anny H. Xiang, Andrea J. Sharma, Sagori Mukhopadhyay, Karen M. Puopolo, Stephanie J. Schrag, Poornima Kunani, Corinna Koebnick
Summary: Exposure to intrapartum antibiotic prophylaxis for reducing perinatal group B streptococcal disease is linked to increased childhood body mass index (BMI) that persists until the age of 10, compared to no exposure (Delta BMI at 10 years: vaginal delivery 0.14 kg/m(2), caesarean 0.40 kg/m(2)).
