Imidazotriazines: Spleen Tyrosine Kinase (Syk) Inhibitors Identified by Free-Energy Perturbation (FEP)

Accurate and Reliable Prediction of Relative Ligand Binding Potency in Prospective Drug Discovery by Way of a Modern Free-Energy Calculation Protocol and Force Field

(2015) Lingle Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Discovery of GS-9973, a Selective and Orally Efficacious Inhibitor of Spleen Tyrosine Kinase

(2014) Kevin S. Currie et al.   JOURNAL OF MEDICINAL CHEMISTRY

Identification of Type-II Inhibitors Using Kinase Structures

(2012) Frank Lovering et al.   Chemical Biology & Drug Design

The status of fostamatinib in the treatment of rheumatoid arthritis

(2012) Jorge Morales-Torres   Expert Review of Clinical Immunology

Biophysical Limits of Protein–Ligand Binding

(2012) Richard D. Smith et al.   Journal of Chemical Information and Modeling

Rational Design of Highly Selective Spleen Tyrosine Kinase Inhibitors

(2012) Matthew C. Lucas et al.   JOURNAL OF MEDICINAL CHEMISTRY

The Syk kinase as a therapeutic target in leukemia and lymphoma

(2011) Dimitar G Efremov et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

What Do Medicinal Chemists Actually Make? A 50-Year Retrospective

(2011) W. Patrick Walters et al.   JOURNAL OF MEDICINAL CHEMISTRY

The Src, Syk, and Tec family kinases: Distinct types of molecular switches

(2010) J. Michael Bradshaw   CELLULAR SIGNALLING

An analysis of the diaminopyrimidine patent estates describing spleen tyrosine kinase inhibitors by Rigel and Portola

(2010) William J Moore et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Therapeutic Targeting of Syk in Autoimmune Diabetes

(2010) L. Colonna et al.   JOURNAL OF IMMUNOLOGY

Syk and pTyr'd: Signaling through the B cell antigen receptor

(2009) Robert L. Geahlen   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The tyrosine kinase network regulating mast cell activation

(2009) Alasdair M. Gilfillan et al.   IMMUNOLOGICAL REVIEWS

Molecular Mechanism of the Syk Activation Switch

(2008) Emily Tsang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Perspective on Free-Energy Perturbation Calculations for Chemical Equilibria

(2008) William L. Jorgensen et al.   Journal of Chemical Theory and Computation