Article
Nutrition & Dietetics
Reka A. Vass, Gabriella Kiss, Edward F. Bell, Robert D. Roghair, Attila Miseta, Jozsef Bodis, Simone Funke, Tibor Ertl
Summary: Pituitary hormones like prolactin and luteinizing hormone were found to be higher in breast milk from mothers of preterm infants compared to term infants. Infant formulas have higher total protein content but do not contain detectable levels of pituitary hormones.
Article
Pediatrics
Sonia Subudhi, Natasha Sriraman
Summary: Milk kinship is an Islamic belief that human milk establishes a kinship between the breastfeeding woman and her nonbiological nursing infant, prohibiting future marriages between milk brothers and sisters. Due to this belief, Muslim families may be reluctant to use donor human milk from milk banks. Health care providers should be aware of this belief in order to have respectful and informed conversations with families.
Article
Nutrition & Dietetics
Reka A. Vass, Edward F. Bell, Robert D. Roghair, Gabriella Kiss, Simone Funke, Szilvia Bokor, Denes Molnar, Attila Miseta, Jozsef Bodis, Kalman Kovacs, Tibor Ertl
Summary: The study examined the levels of insulin, testosterone, total protein, and albumin in breast milk, donor milk, and infant formulas. It found that in preterm breast milk, the concentration of insulin was lower and the concentration of testosterone was higher during the first 2 months compared to the period between the 3rd and 6th months. Infant formulas did not contain insulin or testosterone.
Review
Nutrition & Dietetics
Mateusz Jankiewicz, Linde van Lee, Mirthe Biesheuvel, Elske M. Brouwer-Brolsma, Lucie van der Zee, Hania Szajewska
Summary: A systematic evaluation of goat-milk-based infant formulas (GMFs) compared to cow-milk-based formulas (CMFs) found no significant differences in infant growth and safety parameters. Although there were some concerns and biases in the included studies, the results provide reassurance that GMFs are similarly safe and well tolerated as CMFs for infants.
Article
Biology
Xuan Jiang, Xiaoqiang Zou, Zhonghao Chao, Xiuli Xu
Summary: Human milk is considered the best choice for infant feeding, and human milk fat plays a crucial role in infant growth and development. When breastfeeding is not possible, infant formula should have a composition similar to human milk fat in order to meet the nutritional needs of infants. Currently, the preparation of human milk fat substitutes focuses on simulating fatty acid composition, using structured lipids, and adding milk fat globule membrane supplements. Evaluation and regulation of these substitutes in infant formula are also important.
Article
Obstetrics & Gynecology
A. Brown, N. Shenker
Summary: Receiving donor human milk has a positive impact on the health and development of infants and the mental and physical health of parents. It also promotes family wellbeing. Some parents may face challenges, but receiving donor human milk helps motivate mothers to continue breastfeeding.
BMC PREGNANCY AND CHILDBIRTH
(2022)
Article
Nutrition & Dietetics
Alexandra Thajer, Esther Teunissen, Theresa Kainz, Elisabeth Calek, Karin Harreiter, Angelika Berger, Christoph Binder
Summary: If maternal own milk is not available, pooled donor milk is commonly used as an alternative. However, it contains less protein and fat compared to maternal milk and may affect growth. Donor milk from mothers of preterm infants is a potential alternative with higher protein levels, but its impact on growth and body composition is unclear.
Article
Biology
Reka A. Vass, Gabriella Kiss, Edward F. Bell, Attila Miseta, Jozsef Bodis, Simone Funke, Szilvia Bokor, Denes Molnar, Balazs Kosa, Anna A. Kiss, Timea Takacs, Flora Dombai, Tibor Ertl
Summary: This study examines the hormone content in different forms of infant feeding and finds that breast milk contains thyroid hormones, while infant formulas lack them. This raises the question of whether formula-fed infants should be supplemented with thyroid hormones.
Article
Nutrition & Dietetics
Solange Bramer, Robert Boyle, Gillian Weaver, Natalie Shenker
Summary: This study evaluated the growth outcomes of term infants receiving DHM from a UK milk bank, showing that DHM, either as a sole milk source or supplement, was well-tolerated and demonstrated adequate growth. It suggests that DHM could be an effective feeding alternative for term infants who cannot be breastfed.
MATERNAL AND CHILD NUTRITION
(2021)
Article
Nutrition & Dietetics
Nancy E. Moran, Joshua Wade, Rachel Stroh, Barbara Stoll, Gregory Guthrie, Amy B. Hair, Douglas G. Burrin
Summary: The study found that preterm pigs fed with donor human milk had higher concentrations of liver beta-carotene compared to those fed with premature infant formula. However, liver vitamin A stores were higher in pigs fed with infant formula. Additionally, plasma, liver, and jejunum concentrations of lutein, zeaxanthin, and lycopene were higher in pigs fed with donor human milk. The study suggests that further research should be conducted to investigate the bioactivity and bioavailability of carotenoids in infants.
JOURNAL OF NUTRITION
(2023)
Article
Pediatrics
Kefeng Li, Kerri Bertrand, Jane C. Naviaux, Jonathan M. Monk, Alan Wells, Lin Wang, Sai Sachin Lingampelly, Robert K. Naviaux, Christina Chambers
Summary: The chemical analysis of human milk can predict the risk of neurodevelopmental delay in infants, allowing for early interventions before symptoms appear.
PEDIATRIC RESEARCH
(2023)
Article
Nutrition & Dietetics
Jose David Pineiro-Ramos, Anna Parra-Llorca, Isabel Ten-Domenech, Maria Gormaz, Amparo Ramon-Beltran, Maria Cernada, Guillermo Quintas, Maria Carmen Collado, Julia Kuligowski, Maximo Vento
Summary: The study revealed significant differences in metabolic signatures and microbiota composition between own mother's milk and donor human milk, showing that feeding different types of milk can impact the metabolism and microbiota of preterm infants. This information could lead to new hypotheses and further studies to assess the short- and long-term implications of these changes.
CLINICAL NUTRITION
(2021)
Article
Pediatrics
Shetal Shah, Emily Miller, Allison Rose, Krystle Perez
Summary: Pasteurized donor human milk (PDHM) has been shown to reduce the incidence of necrotizing enterocolitis in very low birth weight infants. However, lack of Medicaid and private insurance coverage for PDHM use in neonatal intensive care units leads to disparities based on birth state and socioeconomic status. Through collaboration between local and national American Academy of Pediatrics (AAP) chapters, a PDHM Advocacy Toolkit was created to promote Medicaid coverage. Over 5 years, advocacy efforts led by neonatologists and incentivized by AAP funds resulted in 5 additional states providing Medicaid payment for PDHM, increasing the coverage to over 55% of nationally born very low birth weight infants. This case study provides a template for other pediatric specialists to advocate for niche-focused issues at the state level.
Article
Nutrition & Dietetics
Linda P. Siziba, Caroline Baier, Elisabeth Puetz, Rudolf Ascherl, Thomas Wendt, Ulrich H. Thome, Corinna Gebauer, Jon Genuneit
Summary: This study describes the feeding patterns of hospitalized infants, including human milk provided by a donor milk bank. The results show that a variety of human milk feeds, including raw human milk, are dispensed by the milk bank during hospitalization. The study highlights the important role of raw human milk in the feeding of hospitalized infants.
FRONTIERS IN NUTRITION
(2023)
Article
Cardiac & Cardiovascular Systems
Yasbanoo Moayedi, Eduard Rodenas-Alesina, Brigitte Mueller, Chun-Po S. Fan, Wida S. Cherikh, Josef Stehlik, Jeffrey J. Teuteberg, Heather J. Ross, Kiran K. Khush
Summary: European heart transplantation centers are more likely to accept higher-risk donor hearts than North American centers. The acceptance of higher-risk donor hearts is associated with higher survival rates in European centers.
CIRCULATION-HEART FAILURE
(2023)
Article
Immunology
Karen M. Puopolo, Sagori Mukhopadhyay, Nellie Hansen, Dustin D. Flannery, Rachel G. Greenberg, Pablo J. Sanchez, Edward F. Bell, Sara B. DeMauro, Myra H. Wyckoff, Eric C. Eichenwald, Barbara J. Stoll
Summary: This study found that the incidence of GBS disease did not change significantly among extremely preterm infants during the study period. Infants with GBS early-onset disease had a higher risk of death or neurodevelopmental impairment compared to those with other infections or uninfected infants. GBS late-onset disease did not have a significant impact on the risk of death or NDI.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Obstetrics & Gynecology
Dustin D. Flannery, Molly Passarella, Sagori Mukhopadhyay, Miren B. Dhudasia, Jeffrey S. Gerber, Scott A. Lorch, Sean Hennessy, Karen M. Puopolo
Summary: This study found that infants discharged from the NICU had a higher antibiotic utilization rate in early childhood compared to non-NICU infants.
JOURNAL OF PERINATOLOGY
(2022)
Article
Obstetrics & Gynecology
Heather H. Burris, Anne M. Mullin, Miren B. Dhudasia, Dustin D. Flannery, Sagori Mukhopadhyay, Madeline R. Pfeifer, Emily C. Woodford, Sara M. Briker, Jourdan E. Triebwasser, Jeffrey S. Morris, Diana Montoya-Williams, Sigrid Gouma, Scott E. Hensley, Karen M. Puopolo
Summary: Neighborhood deprivation and crowding were found to be associated with SARS-CoV-2 seropositivity in pregnant women, while segregation was not. Crowded housing may explain 10.2% of the disparity between Black and White individuals, while neighborhood deprivation may explain 6.7% of the disparity between Hispanic and White individuals.
OBSTETRICS AND GYNECOLOGY
(2022)
Letter
Obstetrics & Gynecology
Jourdan E. Triebwasser, Miren B. Dhudasia, Sagori Mukhopadhyay, Dustin D. Flannery, Sigrid Gouma, Scott E. Hensley, Karen M. Puopolo
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Article
Obstetrics & Gynecology
Dustin D. Flannery, Alvaro Zevallos Barboza, Madeline R. Pfeifer, Mark L. Hudak, Kimberly Barnette, Trace R. Getzlaff, Sascha R. Ellington, Kate R. Woodworth, Miren B. Dhudasia, Sagori Mukhopadhyay, Danielle D. Weinberg, Elizabeth E. Foglia, Karen M. Puopolo
Summary: This study describes the 1-month outcomes of newborns born to persons with perinatal COVID-19. The results showed that symptomatic pregnant persons were more likely to have a preterm delivery and their newborns were more likely to test positive for SARS-CoV-2. However, none of the newborns tested positive for SARS-CoV-2 within 1 month after discharge.
JOURNAL OF PERINATOLOGY
(2022)
Review
Obstetrics & Gynecology
Dustin D. Flannery, Karen M. Puopolo, Nellie Hansen, Pablo J. Sanchez, Barbara J. Stoll
Summary: The Neonatal Research Network (NRN) has conducted studies on the epidemiology of neonatal infections, providing critical data for national guidance and research into optimal approaches to infection diagnosis and treatment.
SEMINARS IN PERINATOLOGY
(2022)
Article
Immunology
Sagori Mukhopadhyay, Hannah L. Itell, Erica Hartman, Emily Woodford, Miren B. Dhudasia, Justin T. Steppe, Sarah Valencia, Hunter Roark, Kelly C. Wade, Kristin E. D. Weimer, Sallie R. Permar, Karen M. Puopolo
Summary: This study aimed to find a convenient screening method for managing pCMV in VLBW infants. The results showed that maternal breast milk can serve as a reliable alternative sample to determine CMV serostatus, while serial testing of infant saliva was not adequately sensitive for identifying pCMV acquisition in preterm infants.
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2022)
Letter
Medicine, General & Internal
Dustin D. Flannery, Alvaro Zevallos Barboza, Kelly C. Wade, Madeline R. Pfeifer, Jeffrey S. Gerber, Jeffrey S. Morris, Karen M. Puopolo
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Article
Pediatrics
Miren B. Dhudasia, William E. Benitz, Dustin D. Flannery, Lori Christ, David Rub, Giulia Remaschi, Karen M. Puopolo, Sagori Mukhopadhyay
Summary: This retrospective cohort study compared the impact of using and not using C-reactive protein (CRP) on the diagnosis of early-onset sepsis. The results showed that CRP had low sensitivity and specificity in diagnosing early-onset sepsis, making it unsuitable as a decision-making indicator. Not using CRP did not significantly affect patient outcomes.
JOURNAL OF PEDIATRICS
(2023)
Article
Immunology
Sarah A. Coggins, Erika M. Edwards, Dustin D. Flannery, Jeffrey S. Gerber, Jeffrey D. Horbar, Karen M. Puopolo
Summary: This study describes late-onset Serratia infection in very preterm infants. Serratia infection is associated with lower survival rate and significant morbidity, highlighting the need for recognition and targeted prevention strategies for this opportunistic nosocomial infection.
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2023)
Article
Pediatrics
Mark L. Hudak, Dustin D. Flannery, Kimberly Barnette, Trace Getzlaff, Shiva Gautam, Miren B. Dhudasia, Sagori Mukhopadhyay, Madeline R. Pfeifer, Sascha R. Ellington, Romeo R. Galang, Margaret C. Snead, Kate R. Woodworth, Lauren B. Zapata, Karen M. Puopolo
Summary: The American Academy of Pediatrics National Registry for the Surveillance and Epidemiology of Perinatal coronavirus disease 2019 (COVID-19) (NPC-19) was developed to provide information on the effects of perinatal severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. The study found that early in the pandemic, newborns acquired SARS-CoV-2 infection at variable rates and without apparent short-term effects. Additionally, higher than expected numbers of preterm births and maternal in-hospital deaths were observed.
Article
Pediatrics
Dustin D. Flannery, Erika M. Edwards, Sarah A. Coggins, Jeffrey D. Horbar, Karen M. Puopolo
Summary: This study examines the epidemiology, microbiology, and outcomes of late-onset sepsis among very preterm infants in the United States. The findings reveal a significant proportion of infants suffering from late-onset sepsis, particularly those born at the lowest gestational ages. Infected infants have higher mortality rates and survivors are at increased risk of technology-dependent chronic morbidities.
Article
Medicine, General & Internal
Dustin D. Flannery, Sigrid Gouma, Miren B. Dhudasia, Sagori Mukhopadhyay, Madeline R. Pfeifer, Emily C. Woodford, Sara M. Briker, Jourdan E. Triebwasser, Jeffrey S. Gerber, Jeffrey S. Morris, Madison E. Weirick, Christopher M. McAllister, Scott E. Hensley, Karen M. Puopolo
Summary: This study found that maternal and cord blood IgG antibody levels were higher after COVID-19 vaccination compared with after SARS-CoV-2 infection, with slightly lower placental transfer ratios after vaccination than after infection. The findings suggest that time from infection or vaccination to delivery was the most important factor in transfer efficiency.
Article
Medicine, General & Internal
Jane E. Brumbaugh, Edward F. Bell, Barbara T. Do, Rachel G. Greenberg, Barbara J. Stoll, Sara B. DeMauro, Heidi M. Harmon, Susan R. Hintz, Abhik Das, Karen M. Puopolo
Summary: This study aimed to report the incidence of late-onset meningitis (LOM) during birth hospitalization and the neurodevelopmental outcomes at 18 to 26 months' corrected age in children born extremely preterm. The results showed a decreasing incidence of LOM, and both LOM and late-onset sepsis (LOS) were associated with an increased risk of death or neurodevelopmental impairment (NDI), with varying risk depending on the LOM pathogen.
Article
Pediatrics
Margo A. Sidell, Darios Getahun, Sara Y. Tartof, Anny H. Xiang, Andrea J. Sharma, Sagori Mukhopadhyay, Karen M. Puopolo, Stephanie J. Schrag, Poornima Kunani, Corinna Koebnick
Summary: Exposure to intrapartum antibiotic prophylaxis for reducing perinatal group B streptococcal disease is linked to increased childhood body mass index (BMI) that persists until the age of 10, compared to no exposure (Delta BMI at 10 years: vaginal delivery 0.14 kg/m(2), caesarean 0.40 kg/m(2)).