Journal
CHEMISTRY-AN ASIAN JOURNAL
Volume 10, Issue 6, Pages 1304-1310Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/asia.201500106
Keywords
colorimetric; fluorescent probes; pH; porphyrins; ratiometric
Categories
Funding
- Natural Science Foundation of China [21371130]
- National Basic Research Program of China [2011CB707703, 2015CB856503]
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pH measurement is widely used in many fields. Ratiometric pH sensing is an important way to improve the detection accuracy. Herein, five water-soluble cationic porphyrin derivatives were synthesized and their optical property changes with pH value were investigated. Their pH-dependent assembly/disassembly behaviors caused significant changes in both absorption and fluorescence spectra, thus making them promising bimodal ratiometric probes for both colorimetric and fluorescent pH sensing. Different substituent identity and position confer these probes with different sensitive pH-sensing ranges, and the substituent position gives a larger effect. By selecting different porphyrins, different signal intensity ratios and different fluorescence excitation wavelengths, sensitive pH sensing can be achieved in the range of 2.1-8.0. Having demonstrated the excellent reversibility, good accuracy and low cytotoxicity of the probes, they were successfully applied in pH sensing inside living cells.
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