Article
Cardiac & Cardiovascular Systems
Vignesh Chidambaram, Lucas Zhou, Jennie Ruelas Castillo, Amudha Kumar, Samuel K. Ayeh, Akshay Gupte, Jann-Yuan Wang, Petros C. Karakousis
Summary: This study found that higher baseline serum cholesterol levels in TB patients were associated with lower risks of all-cause and infection-related mortality, as well as lower levels of inflammatory markers. Body mass index did not modify or confound this association.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Endocrinology & Metabolism
Genki Kobayashi, Hiroshi Okada, Masahide Hamaguchi, Kazushiro Kurogi, Hiroaki Murata, Masato Ito, Michiaki Fukui
Summary: This study investigated the association between LDL cholesterol, HDL cholesterol, and LDL/HDL ratio and the incidence of diabetes, and identified the cut-off values for incident diabetes.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Oncology
Giovanna Revilla, Lidia Cedo, Mireia Tondo, Antonio Moral, Jose Ignacio Perez, Rosa Corcoy, Enrique Lerma, Victoria Fuste, T. Srivinasa Reddy, Francisco Blanco-Vaca, Eugenia Mato, Joan Carles Escola
Summary: Cholesterol is crucial for various functions in endocrine-related cells, including hormone and steroid production. While LDL-cholesterol and HDL-cholesterol were not consistently associated with endocrine-related cancer risk, LDL receptor plays a critical role in endocrine-related tumor cells by enhancing circulating LDL-C uptake.
SEMINARS IN CANCER BIOLOGY
(2021)
Article
Environmental Sciences
Eleni Papadopoulou, Alina Nicolescu, Line S. Haug, Trine Hus, Calin Deleanu, Hubert Dirven, Birgitte Lindeman
Summary: This study explores the association between serum PFAS concentrations and lipoprotein subclasses. After adjusting for confounders, the adjusted models found positive associations between several PFASs and cholesterol concentrations in large to medium sized HDL and medium sized LDL particles. Significant associations were observed between certain PFASs and cholesterol in large to medium LDL particle sizes among women. The study also found that most PFASs tended to be associated with a reduction in VLDL particle number and VLDL triglyceride.
ENVIRONMENTAL POLLUTION
(2022)
Article
Clinical Neurology
Zhirong Yang, Duncan Edwards, Stephen Burgess, Carol Brayne, Jonathan Mant
Summary: This study investigated the potential associations between blood LDL-C, HDL-C, and triglycerides and post-stroke dementia. The results showed that higher LDL-C levels were associated with an increased risk of dementia, while lower triglyceride levels were associated with a decreased risk. There was no association between HDL-C levels and dementia.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Genetics & Heredity
Ana Catarina Alves, Beatriz Miranda, Oana Moldovan, Raquel Espirito Santo, Raquel Gouveia Silva, Sandra Soares Cardoso, Luisa Diogo, Monica Seidi, Silvia Sequeira, Mafalda Bourbon
Summary: This study aimed to analyze the association between rare lipid disorders and low LDL or low HDL cholesterol in 7 cases. NGS analysis of genes associated with rare forms of low HDL-c or LDL-c identified genetic variants related to rare lipid disorders. NGS proved to be a fundamental key for genetic testing of rare lipid disorders, helping to find the genetic cause of disease in 6/7 patients with low HDL-c and LDL-c.
FRONTIERS IN GENETICS
(2023)
Article
Engineering, Chemical
Fangyuan Zhang, Brittany Macshane, Ryan Searcy, Zuyi Huang
Summary: Cholesterol is a vital component of eukaryotic cell membranes and serves as a precursor for other molecules in the body. Maintaining cholesterol homeostasis is crucial for human health, as high cholesterol increases the risk of heart disease. Mathematical models can be used to study the best approaches to reducing overall cholesterol levels, providing insights into suitable drug targeting reactions or processes.
Article
Public, Environmental & Occupational Health
Xuan Xi, Di Wu, Wenyi Wu, Yuanke Zhou, Qin Zhang, Yujie Wang, Hong Wang, Qin Liu
Summary: This study explores the influence of obesity indicators on the onset age of different pubertal characteristics and tempo among girls. The results show that overweight and obesity before pubertal onset can affect the age of onset and accelerate pubertal tempo. Furthermore, overweight and high waist circumference before menarche also impact the age of menarche.
FRONTIERS IN PUBLIC HEALTH
(2023)
Review
Biochemistry & Molecular Biology
Saeed Aslani, Bahman Razi, Danyal Imani, Keyhan Mohammadi, Tannaz Jamialahmadi, Zeljko Reiner, Amirhossein Sahebkar
Summary: A systematic review and meta-analysis showed that statin therapy effectively lowered levels of total cholesterol, LDL-C, and TG, and increased levels of HDL-C in patients with different CVDs.
CURRENT MEDICINAL CHEMISTRY
(2023)
Article
Cardiac & Cardiovascular Systems
Sifan Qian, Shoujiang You, Yaming Sun, Qiuyi Wu, Xianhui Wang, Weiting Tang, Xiaofeng Dong, Chun-feng Liu, Tan Xu, Yongjun Cao, Chongke Zhong
Summary: This study found a significant positive association between elevated fasting remnant cholesterol levels and abnormal cIMT in patients with ischemic stroke, even in patients with optimal LDL cholesterol levels. Future prospective studies are needed to validate these findings and assess the impact of remnant cholesterol-lowering interventions in patients with ischemic stroke.
CIRCULATION-CARDIOVASCULAR IMAGING
(2021)
Article
Endocrinology & Metabolism
Guotai Sheng, Jiajun Qiu, Maobin Kuang, Nan Peng, Guobo Xie, Yuanqin Chen, Shuhua Zhang, Yang Zou
Summary: This study aimed to evaluate and compare the predictive value of three simple anthropometric indicators of obesity (BMI, WC, and WHtR) for the occurrence of diabetes in the future. The results showed that WC was the best indicator, and WHtR performed best for predicting diabetes in the medium to long term.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Oncology
Pik-Fang Kho, Frederic Amant, Daniela Annibali, Katie Ashton, John Attia, Paul L. Auer, Matthias W. Beckmann, Amanda Black, Louise Brinton, Daniel D. Buchanan, Stephen J. Chanock, Chu Chen, Maxine M. Chen, Timothy H. T. Cheng, Linda S. Cook, Marta Crous-Bous, Kamila Czene, Immaculata De Vivo, Joe Dennis, Thilo Doerk, Sean C. Dowdy, Alison M. Dunning, Matthias Duerst, Douglas F. Easton, Arif B. Ekici, Peter A. Fasching, Brooke L. Fridley, Christine M. Friedenreich, Montserrat Garcia-Closas, Mia M. Gaudet, Graham G. Giles, Ellen L. Goode, Maggie Gorman, Christopher A. Haiman, Per Hall, Susan E. Hankinson, Alexander Hein, Peter Hillemanns, Shirley Hodgson, Erling A. Hoivik, Elizabeth G. Holliday, David J. Hunter, Angela Jones, Peter Kraft, Camilla Krakstad, Diether Lambrechts, Loic Le Marchand, Xiaolin Liang, Annika Lindblom, Jolanta Lissowska, Jirong Long, Lingeng Lu, Anthony M. Magliocco, Lynn Martin, Mark McEvoy, Roger L. Milne, Miriam Mints, Rami Nassir, Geoffrey Otton, Claire Palles, Loreall Pooler, Tony Proietto, Timothy R. Rebbeck, Stefan P. Renner, Harvey A. Risch, Matthias Ruebner, Ingo Runnebaum, Carlotta Sacerdote, Gloria E. Sarto, Fredrick Schumacher, Rodney J. Scott, V. Wendy Setiawan, Mitul Shah, Xin Sheng, Xiao-Ou Shu, Melissa C. Southey, Emma Tham, Ian Tomlinson, Jone Trovik, Constance Turman, Jonathan P. Tyrer, David van den Berg, Zhaoming Wang, Nicolas Wentzensen, Lucy Xia, Yong-Bing Xiang, Hannah P. Yang, Herbert Yu, Wei Zheng, Penelope M. Webb, Deborah J. Thompson, Amanda B. Spurdle, Dylan M. Glubb, Tracy A. O'Mara
Summary: This study used Mendelian randomization analysis to investigate the relationship between blood lipids and endometrial cancer risk. Genetically elevated LDL cholesterol levels were associated with reduced risk of endometrial cancer, while higher predicted HDL cholesterol levels were linked to increased risk of non-endometrioid endometrial cancer. Obesity may influence these associations, but triglycerides showed no evidence of involvement in endometrial cancer development.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Obstetrics & Gynecology
Maria C. Adank, Anja K. Johansen, Laura Benschop, Sophia P. Van Streun, Anna M. Smak Gregoor, Linn K. L. Oyri, Monique T. Mulder, Eric A. P. Steegers, Kirsten B. Holven, Jeanine E. Roeters van Lennep
Summary: Maternal lipid levels in early pregnancy are positively associated with childhood lipid levels in offspring, independent of maternal BMI and diet. This suggests that gestational lipid levels can be used as an early predictor of children's long-term health.
BMC PREGNANCY AND CHILDBIRTH
(2022)
Article
Multidisciplinary Sciences
Jae-Chan Ryu, Jae-Han Bae, Sang Hee Ha, Boseong Kwon, Yunsun Song, Deok Hee Lee, Bum Joon Kim, Dong-Wha Kang, Sun U. U. Kwon, Jong S. S. Kim, Jun Young Chang
Summary: This study investigated the association between changes in lipid profiles and the risk of in-stent restenosis. The results showed that improvement of HDL-C levels, TC/HDL-C ratio, and LDL-C/HDL-C ratio were associated with a decreased risk of in-stent restenosis.
Article
Cardiac & Cardiovascular Systems
Wieneke Dijk, Mathilde Di Filippo, Sander Kooijman, Robin van Eenige, Antoine Rimbert, Amandine Caillaud, Aurelie Thedrez, Lucie Arnaud, Amanda Pronk, Damien Garcon, Thibaud Sotin, Pierre Lindenbaum, Enrique Ozcariz Garcia, Jean-Paul Pais De Barros, Laurence Duvillard, Karim Si-Tayeb, Nuria Amigo, Jean-Yves Le Questel, Patrick C. N. Rensen, Cedric Le May, Philippe Moulin, Bertrand Cariou
Summary: The study aims to elucidate the genetic origin of an unexplained combined hypocholesterolemia inherited in a French family. Through next-generation sequencing, a rare variant in the LIPC gene was identified, which cosegregates with the phenotype. This gain-of-function variant increases the phospholipase activity of hepatic lipase and affects circulating lipid and lipoprotein levels. Mouse model studies confirmed the role of this variant in familial combined hypocholesterolemia.
Article
Immunology
N. S. Rasmussen, C. T. Nielsen, C. H. Nielsen, S. Jacobsen
Summary: The release of microvesicles expressing G3BP and dsDNA is significantly increased in SLE patients with active LN. Stimulation with TLR-9 agonist ODN2395 induces the release of MVs expressing G3BP and dsDNA from PBMCs, and this effect is not affected by co-stimulation with gardiquimod or IFN-alpha inhibitor IN-1.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2021)
Article
Hematology
Sarah Weischendorff, Henrik Sengelov, Anders Juul, Claus H. Nielsen, Lars P. Ryder, Katrine Kielsen, Klaus Mueller
Summary: The study found that high levels of IGF-1 and IGFBP-3 are associated with faster reconstitution of different blood cell populations after HSCT, including reticulocytes, thrombocytes, lymphocytes, neutrophil engraftment time, and circulating natural killer cells.
EUROPEAN JOURNAL OF HAEMATOLOGY
(2022)
Article
Endocrinology & Metabolism
Elvira Silajdzija, Sofie Bliddal, Line Borgwardt, Maria Rossing, Anne Jarlov, Claus Henrik Nielsen, Ulla Feldt-Rasmussen
Summary: This article reports a case of autoimmune polyglandular syndrome type II (APS II) in a patient who was initially diagnosed with hypothyroidism and presented with fatigue and rapid weight loss. Through examinations and genetic sequencing, the final diagnoses included Hashimoto's thyroiditis, Addison's disease, vitiligo, and pernicious anemia. The findings suggest that awareness of potential polyautoimmunity in patients with thyroid disease can improve diagnosis and even be life-saving.
HORMONES-INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM
(2022)
Article
Immunology
Blaine G. Fritz, Julius B. Kirkegaard, Claus Henrik Nielsen, Klaus Kirketerp-Maller, Matthew Malone, Thomas Bjarnsholt
Summary: This study analyzed the transcriptome of lower extremity ulcers to identify host gene expression patterns associated with bacterial infections. The results showed that these transcriptome patterns were often inconsistent with clinical infection severity classifications. A set of 20 genes, including immune-associated genes, accurately identified samples with signs of infection. This suggests that transcriptomic fingerprinting could be a useful objective method for classifying infection severity and studying host-pathogen interactions.
Article
Dentistry, Oral Surgery & Medicine
Christian Damgaard, Laura Massarenti, Anne Katrine Danielsen, Jonas H. Graversen, Palle Holmstrup, Claus H. Nielsen, Yaseelan Palarasah
Summary: Complement activation is increased in patients with periodontitis, but there is no difference between PD-B and PD-C. PD-B is associated with systemic complement activation.
JOURNAL OF PERIODONTOLOGY
(2022)
Article
Dermatology
Christian Enevold, Nikolai Loft, Anne Bregnhoj, Claus Zachariae, Lars Iversen, Lone Skov, Claus Henrik Nielsen
Summary: This case series study suggests an association between drug monitoring and clinical treatment response. Monitoring patient levels of circulating brodalumab may aid clinical decision-making and help prevent ineffective therapy.
Article
Immunology
Dina Leth Moller, Katrine Kielsen, Claus Henrik Nielsen, Henrik Sengelov, Anders Elm Pedersen, Lars Peter Ryder, Klaus Muller
Summary: This study suggests a role of TSLP in immune reconstitution and alloreactivity post-HSCT.
IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Laura Massarenti, Christina Aniol-Nielsen, Christian Enevold, Henrik Toft-Hansen, Claus Henrik Nielsen
Summary: Single nucleotide polymorphisms (SNPs) in insulin and insulin receptor genes may influence the interaction between the two molecules, and anti-insulin antibodies (IAs) may be associated with insulin treatment in patients with diabetes. This study found that two SNPs in the human insulin gene and two SNPs in the insulin receptor gene were associated with type 1 diabetes and glycaemic control.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Laura Massarenti, Christian Enevold, Dres Damgaard, Peter Riis Hansen, Morten Frisch, Niels Odum, Soren Jacobsen, Claus Henrik Nielsen
Summary: Epidemiological studies have shown an association between periodontitis and rheumatoid arthritis (RA). This study investigated whether this association is influenced by genetic polymorphisms. The study found that carrying specific alleles of certain genes increased the risk of RA in individuals with periodontitis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Hematology
Sarah Weischendorff, Silvia De Pietri, Mathias Rathe, Thomas Leth Frandsen, Henrik Hasle, Claus H. Nielsen, Claus Moser, Klaus Mueller
Summary: This study investigated whether measurements of neutrophil chemotaxis could be used as risk markers for bloodstream infections (BSI) in children with acute lymphoblastic leukemia (ALL). The results showed that patients who developed BSI during induction treatment had increased levels of chemokines CXCL1 and CXCL8, suggesting that these markers may help identify patients at increased risk of BSI during chemotherapy-induced neutropenia.
EUROPEAN JOURNAL OF HAEMATOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Clara Sophie Bramsen Andersen, Amanda Kvist-Hansen, Mie Siewertsen, Christian Enevold, Peter Riis Hansen, Diljit Kaur-Knudsen, Claus Zachariae, Claus Henrik Nielsen, Nikolai Loft, Lone Skov
Summary: This study examined the usefulness of various inflammation biomarkers in personalizing biologic treatment for psoriasis patients. It was found that the neutrophil-to-lymphocyte ratio (NLR) and interleukin-6 (IL-6) levels could serve as predictive biomarkers for treatment response to TNF-alpha inhibitor therapy. The study also measured other biomarkers such as TNF-alpha, IL-1 beta, IFN-alpha, IL-17A, IL-6, soluble IL-6 receptor (sIL-6R), and soluble IL-6 signal transducer (sIL-6ST) in different patient groups.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Maria Teresa Martin Monreal, Bjarke E. Hansen, Pernille F. Iversen, Christian Enevold, Niels Odum, Finn Sellebjerg, Peter Hojrup, Marina Rode von Essen, Claus H. Nielsen
Summary: The research suggests that citrullination, a post-translational modification, may play a role in the development of multiple sclerosis (MS). The autoimmune response to myelin basic protein (MBP) is enhanced when it is hypercitrullinated in MS patients. In addition, citMBP binds more effectively to HLA-DR15, which is associated with MS, compared to native MBP. These findings point to the importance of citrullination in breaching tolerance to MBP and maintaining the autoimmune response in MS patients.
JOURNAL OF AUTOIMMUNITY
(2023)
Review
Oncology
Peter Schmidt-Andersen, Anna Stage, Anna Pouplier, Louise H. Bastholm, Klaus G. Mueller, Anders Larsen, Kirsten K. Ness, Hanne B. Larsen, Jan Christensen, Martin K. Fridh
Summary: The evidence suggests that children with cancer experience impaired cardiorespiratory fitness, muscle strength, and physical performance within the first month after diagnosis. However, the limited number of studies and the clinical heterogeneity of the available evidence reduces its certainty.
PEDIATRIC BLOOD & CANCER
(2023)
Article
Hematology
Marte B. Kammersgaard, Katrine Kielsen, Claus H. Nielsen, Marianne Ifversen, Anne-Helene Bohr, Klaus Muller Ller
Summary: Neutrophil engraftment is crucial for successful hematopoietic stem cell transplantation (HSCT), but it may also lead to transplant-related complications. This study investigated the relationship between the neutrophil activation marker MRP-8/14, neutrophil recovery, and toxicities after pediatric HSCT. The results showed significant associations between MRP-8/14 levels and neutrophil engraftment, bacterial bloodstream infections, engraftment syndrome, and acute graft-versus-host disease.
TRANSPLANTATION AND CELLULAR THERAPY
(2023)
Letter
Biophysics
Sidsel Mathiesen, Christian Fuglesang S. Jensen, Anna Byrjalsen, Lise Aksglaede, Niels Jorgensen, Dana Ohl, Jens Sonksen, Klaus Muller
BONE MARROW TRANSPLANTATION
(2023)