Article
Nutrition & Dietetics
Shweta Khandelwal, Dimple Kondal, Monica Chaudhry, Kamal Patil, Mallaiah Kenchaveeraiah Swamy, Gangubai Pujeri, Swati Babu Mane, Yashaswi Kudachi, Ruby Gupta, Usha Ramakrishnan, Aryeh D. Stein, Dorairaj Prabhakaran, Nikhil Tandon
Summary: This study conducted in India examined the impact of supplementing pregnant women with 400 mg/day of algal DHA on newborn anthropometry and gestational duration. The results showed that there were no significant differences in birth weight, length, or head circumference of offspring between the group supplemented with DHA and the placebo group.
Article
Nutrition & Dietetics
Akiko Harauma, Hajime Yoshihara, Yukino Hoshi, Kei Hamazaki, Toru Moriguchi
Summary: This study investigated the impact of consuming perilla oil or fish oil during pregnancy on postpartum mental health, as well as the association between fatty acids in maternal red blood cells and mental health risk factors. The results showed a lower proportion of high postnatal depression scores in the perilla oil group compared to the historical control group, while there was no significant difference in the fish oil group. The intake of omega-3 fatty acids during pregnancy did not have a marked effect on mother-to-infant bonding. The study suggests that consuming alpha-linolenic acid during pregnancy may help stabilize postpartum mental health.
Article
Nutrition & Dietetics
Jacqueline F. Gould, Peter J. Anderson, Lisa N. Yelland, Robert A. Gibson, Maria Makrides
Summary: This study found that prenatal DHA supplementation did not provide benefits to childhood behavior and may instead have a negative impact on behavioral functioning.
Article
Nutrition & Dietetics
Marta Rivera-Pasquel, Mario Flores-Aldana, Maria-Socorro Parra-Cabrera, Amado David Quezada-Sanchez, Armando Garcia-Guerra, Jorge Maldonado-Hernandez
Summary: The study showed significant improvement in lipid profile among children who consumed PUFAs-fortified milk formula, with no significant differences in growth and micronutrient status between the two groups. Consumption of both supplements was adequate and stable throughout the intervention.
Article
Biochemistry & Molecular Biology
Charlotte L. Bahnfleth, Barbara J. Strupp, Marie A. Caudill, Richard L. Canfield
Summary: This study demonstrates the positive effect of maternal choline supplementation on offspring's sustained attention. Children whose mothers consumed 930 mg choline per day during the third trimester showed superior performance in attention tasks compared to the group whose mothers consumed 480 mg choline per day.
Review
Nutrition & Dietetics
Jacqueline F. Gould, Rachel M. Roberts, Maria Makrides
Summary: The review analyzed the effects of DHA interventions in randomized controlled trials during the first 1000 days. Results showed limited evidence of DHA supplementation having any effect on behavioral development, with some trials even detecting adverse effects. Future research should focus on evaluating the impact of DHA intervention on behavioral functioning.
Article
Nutrition & Dietetics
Sonia Tandon, Ines Gonzalez-Casanova, Albino Barraza-Villarreal, Isabelle Romieu, Hans Demmelmair, Dean P. Jones, Berthold Koletzko, Aryeh D. Stein, Usha Ramakrishnan
Summary: Prenatal DHA supplementation did not have significant effects on offspring metabolism, but differences were found in infants with interaction with maternal FADS gene SNP rs174602. Offspring of minor allele carriers showed enriched amino acid and aminosugars metabolism pathways with DHA supplementation, while noncarriers exhibited decreased metabolites in the tricarboxylic acid cycle and galactose metabolism pathways.
JOURNAL OF NUTRITION
(2021)
Article
Agriculture, Multidisciplinary
Xiankang Xu, Weixue Zhao, Yiru Ye, Weining Cui, Lu Dong, Yixin Yao, Kexuan Li, Jianzhong Han, Weilin Liu
Summary: This study aimed to fabricate and evaluate novel DHA-anthocyanidin-codelivery liposomes (DA-LPs) for better understanding the absorption and transport mechanisms in the gastrointestinal tract. The results showed that DA-LPs exhibited improved cell viability, cellular uptake, membrane fluidity, and lower ROS compared to single substance-loaded liposomes. This suggests that DA-LPs may be beneficial for enhancing nutrient absorption and reducing oxidative stress in the intestine.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Nutrition & Dietetics
S. E. Carlson, B. J. Gajewski, C. J. Valentine, S. A. Sands, A. R. Brown, E. H. Kerling, S. A. Crawford, C. S. Buhimschi, C. P. Weiner, M. Cackovic, E. A. DeFranco, D. P. Mudaranthakam, L. K. Rogers
Summary: This study aimed to determine the rate of early preterm birth (EPTB) and preterm birth (PTB) in participants who adhered to a daily dose of 1000 mg/docosahexaenoic acid (DHA). The study found that adherence to a high dose of DHA resulted in lower rates of EPTB and PTB, particularly in women with low baseline levels of DHA.
CLINICAL NUTRITION
(2023)
Article
Food Science & Technology
Shingo Fujimura, Jun Yoshinaga
Summary: National statistics show a decreasing trend in seafood consumption in Japan since the mid-1990s. This study assessed the risks and benefits of this trend by estimating the intake of docosahexaenoic acid (DHA) and methylmercury (MeHg) in women of childbearing age. The results indicate a significant decrease in DHA (2.8 mg/day per year) and MeHg (0.19 μg Hg/day per year) intake during the period of 2011-2019. However, the effect on infant IQ was found to be constant or even increasing due to the decreasing adverse effect of MeHg and the saturated benefits of DHA on infant IQ.
Article
Nutrition & Dietetics
Alejandro Martinez-Gayo, Elisa Felix-Soriano, Neira Sainz, Pedro Gonzalez-Muniesa, Maria J. Moreno-Aliaga
Summary: Obesity and aging promote chronic low-grade systemic inflammation. This study aimed to analyze the effects of long-term physical exercise and/or omega-3 fatty acid DHA supplementation on muscle metabolism, inflammation, muscle damage/regeneration, and myokine expression in aged and obese mice. The results showed that long-term exercise can prevent the deleterious effects of aging and obesity on muscle function.
Article
Nutrition & Dietetics
Amran Daher-Abdi, Sandra Olvera Hernandez, Luis Antonio Reyes Castro, Carla Elena Mezo-Gonzalez, Mikael Croyal, Juan Antonio Garcia-Santillan, Khadija Ouguerram, Elena Zambrano, Francisco Bolanos-Jimenez
Summary: Maternal supplementation with DHA during pregnancy was found to protect offspring against obesity and metabolic disorders caused by a high-fat, high-sugar diet. While the diet led to increased body weight and liver fat accumulation, DHA supplementation prevented glucose intolerance and elevated insulin levels. The protective effects against hepatic steatosis persisted with age and were associated with decreased expression of lipogenic genes.
Article
Nutrition & Dietetics
Erandi Hewawasam, Carmel T. Collins, Beverly S. Muhlhausler, Lisa N. Yelland, Lisa G. Smithers, John Colombo, Maria Makrides, Andrew J. McPhee, Jacqueline F. Gould
Summary: This study found that DHA supplementation in infants born preterm did not improve attention at 18 months' corrected age.
BRITISH JOURNAL OF NUTRITION
(2021)
Review
Medicine, General & Internal
Isabelle Marc, Amelie Boutin, Etienne Pronovost, Norma Maria Perez Herrera, Mireille Guillot, Frederic Bergeron, Lynne Moore, Thomas R. Sullivan, Pascal M. Lavoie, Maria Makrides
Summary: This systematic review and meta-analysis examines the association between daily omega-3 docosahexaenoic acid (DHA) supplementation and bronchopulmonary dysplasia (BPD) in preterm infants born at less than 29 weeks' gestation. The study found that high-dose DHA supplementation during the neonatal period was not associated with BPD overall, but was inversely associated with BPD in trials that used a more stringent definition. These findings suggest that high-dose DHA supplementation should not be recommended for the prevention of BPD in very preterm infants.
Article
Psychology, Multidisciplinary
Vera Cristina Alexandre de Souza, Erika Parlato-Oliveira, Leni Marcia Anchieta, Alexei Manso Correa Machado, Sylvie Viaux Savelon
Summary: This study investigates the impact of prenatal diagnosis of malformation on maternal representations and the quality of early mother-child interactions. The results show that the study group had higher anxiety and depression scores during the gestational phase and significantly higher scores on various factors after the child reached 6 months of age, such as maternal sensitivity, baby involvement, and dyadic reciprocity. However, the control group had higher scores on baby withdrawal and dyadic negative states at 6 months of age.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Neurosciences
Kathleen M. Gustafson, Ke Liao, Nicole B. Mathis, D. Jill Shaddy, Elizabeth H. Kerling, Danielle N. Christifano, John Colombo, Susan E. Carlson
Summary: Prenatal DHA supplementation has a significant impact on the behavior and brain function of offspring, with males benefiting more in terms of inhibitory performance and females exhibiting more conservative behavior. Maternal DHA status appears to influence the development of brain regions responsible for visual processing.
NUTRITIONAL NEUROSCIENCE
(2022)
Article
Nutrition & Dietetics
Erandi Hewawasam, Carmel T. Collins, Beverly S. Muhlhausler, Lisa N. Yelland, Lisa G. Smithers, John Colombo, Maria Makrides, Andrew J. McPhee, Jacqueline F. Gould
Summary: This study found that DHA supplementation in infants born preterm did not improve attention at 18 months' corrected age.
BRITISH JOURNAL OF NUTRITION
(2021)
Article
Pediatrics
Kathleen M. Gustafson, Danielle N. Christifano, Dirk Hoyer, Alexander Schmidt, Susan E. Carlson, John Colombo, Nicole B. Mathis, Scott A. Sands, Lynn Chollet-Hinton, Alexandra R. Brown, Dinesh Pal Mudaranthakam, Byron J. Gajewski
Summary: This study aimed to investigate the effect of maternal DHA supplementation on maternal-infant DHA equilibrium and fetal neurodevelopment. The results showed that pregnant women who received a higher dose of DHA were more likely to achieve maternal-infant DHA equilibrium at delivery, but this equilibrium status did not significantly impact fetal neurodevelopment.
PEDIATRIC RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
S. A. Crawford, D. N. Christifano, E. H. Kerling, B. J. Gajewski, C. J. Valentine, K. M. Gustafson, N. B. Mathis, J. T. Camargo, H. D. Gibbs, D. K. Sullivan, S. A. Sands, S. E. Carlson
Summary: This study used two questionnaire methods and found that DHA-FFQ more accurately estimated DHA intake in pregnant women and provided more reliable intake data. In addition, maternal age, parity, and socioeconomic status were also associated with RBC-DHA.
PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS
(2022)
Article
Nutrition & Dietetics
Jamie V. de Seymour, Kathryn L. Beck, Cathryn A. Conlon, Mary Beatrix Jones, John Colombo, Yin-Yin Xia, Ting-Li Han, Hong-Bo Qi, Hua Zhang, Philip N. Baker
Summary: This study investigated the relationship between dietary pattern consumption in early pregnancy and pregnancy/infant outcomes. The results showed that a dietary pattern high in pasta, sweetened beverages, and oils and condiments was associated with lower infant neurodevelopment scores, lower placental weight, and higher tricep skinfold thickness. A dietary pattern high in fish, poultry, and vegetables was associated with higher gestational weight gain.
FRONTIERS IN NUTRITION
(2022)
Article
Nutrition & Dietetics
S. E. Carlson, B. J. Gajewski, C. J. Valentine, S. A. Sands, A. R. Brown, E. H. Kerling, S. A. Crawford, C. S. Buhimschi, C. P. Weiner, M. Cackovic, E. A. DeFranco, D. P. Mudaranthakam, L. K. Rogers
Summary: This study aimed to determine the rate of early preterm birth (EPTB) and preterm birth (PTB) in participants who adhered to a daily dose of 1000 mg/docosahexaenoic acid (DHA). The study found that adherence to a high dose of DHA resulted in lower rates of EPTB and PTB, particularly in women with low baseline levels of DHA.
CLINICAL NUTRITION
(2023)
Article
Pharmacology & Pharmacy
Byron J. Gajewski, Susan E. Carlson, Alexandra R. Brown, Dinesh Pal Mudaranthakam, Elizabeth H. Kerling, Christina J. Valentine
Summary: This paper investigates the value of a two-armed Bayesian response adaptive randomization (RAR) design in studying the effects of different doses of docosahexaenoic acid on early preterm birth rates during pregnancy. It describes how the RAR was used in the study and highlights its promising potential for future use in two-armed studies.
JOURNAL OF BIOPHARMACEUTICAL STATISTICS
(2023)
Article
Nutrition & Dietetics
D. N. Christifano, S. A. Crawford, G. Lee, A. R. Brown, J. T. Camargo, E. H. Kerling, B. J. Gajewski, C. J. Valentine, K. M. Gustafson, E. A. DeFranco, S. E. Carlson
Summary: Assessing DHA intake can identify pregnancies that benefit from high dose DHA supplementation, reducing the risk of preterm birth.
CLINICAL NUTRITION ESPEN
(2023)
Article
Pediatrics
John Colombo, Cheryl L. Harris, Jennifer L. Wampler, Weihong Zhuang, D. Jill Shaddy, Bryan Y. Liu, Steven S. Wu
Summary: The aim of this study was to evaluate the neurodevelopmental outcomes at 5.5 years of age in children who were fed with cow milk-based infant formula (control) or formula with added sources of bovine milk fat globule membrane and bovine lactoferrin. The results showed that the children who received the added ingredients demonstrated better cognitive development, inhibitory control, flexibility/rule learning, and behavior/emotion compared to the control group.
JOURNAL OF PEDIATRICS
(2023)
Article
Health Care Sciences & Services
Dinesh Pal Mudaranthakam, Alexandra Brown, Elizabeth Kerling, Susan E. Carlson, Christina J. Valentine, Byron Gajewski
Summary: This study discusses the advantages and challenges of multisite clinical trials, as well as the application of a clinical trial management system called CRIS developed by the University of Kansas Medical Center in a National Institute of Child Health and Human Development-funded trial. The results demonstrate that CRIS can improve trial efficiency and management, and provide templates and guidance for future multisite trials.
JMIR FORMATIVE RESEARCH
(2021)
