Review
Biochemistry & Molecular Biology
Chiedozie Kenneth Ugwoke, Erika Cvetko, Nejc Umek
Summary: There is a close relationship between microvascular dysfunction and insulin resistance in obesity, with changes in skeletal muscle microcirculation leading to impaired insulin function and disturbed glucose homeostasis. Various molecular mechanisms and potential pharmacological treatments have been identified.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Josko Bozic, Marko Kumric, Tina Ticinovic Kurir, Ivan Males, Josip A. Borovac, Dinko Martinovic, Marino Vilovic
Summary: The text discusses the crucial role of adropin in cardiovascular diseases and its protective function in endothelium, highlighting the correlation between plasma levels of adropin and disease progression, suggesting adropin may serve as a future biomarker. Further well-designed studies are needed to determine the therapeutic potential of adropin in this context.
Review
Medicine, Research & Experimental
Yuying Zhou, Yunlong Zhu, Jianping Zeng
Summary: Heart failure (HF) is a serious clinical syndrome that occurs at the advanced stage of various cardiovascular diseases, with high mortality and rehospitalization rates. HF has been categorized into three types based on left ventricular ejection fraction (LVEF): HF with reduced EF, HF with mid-range EF, and HF with preserved EF. HFpEF, accounting for approximately 50% of cases, has become the dominant form. The mortality of HFpEF is similar to that of HFrEF, and no well-documented treatment options currently exist to reduce its morbidity and mortality. Understanding the underlying pathological mechanisms is crucial for developing novel effective therapies for HFpEF. This review aims to update the progress on the pathophysiological mechanism of HFpEF.
CURRENT MOLECULAR MEDICINE
(2023)
Review
Cardiac & Cardiovascular Systems
Zijie Lin, Xinyi Lin, Xin Zhao, Chenchao Xu, Bokang Yu, Yiwen Shen, Liliang Li
Summary: This review summarizes the research progress on risk factors and mechanisms of coronary artery spasm (CAS), introduces current knowledge about CAS, and analyzes the advantages and disadvantages of diagnostic approaches.
REVIEWS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Clinical Neurology
Yousef Hannawi
Summary: Cerebral small vessel disease (cSVD) is a pathological process that affects the brain small vessels and leads to vascular cognitive impairment, intracerebral hemorrhage, and acute lacunar ischemic stroke. Despite the lack of specific therapies, recent research has identified several age-dependent processes that play critical roles in cSVD pathogenesis.
TRANSLATIONAL STROKE RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Tatsuya Maruhashi, Yukihito Higashi
Summary: Endothelial dysfunction is crucial in the progression of atherosclerosis and is significantly associated with diabetes mellitus and oxidative stress. Selecting appropriate therapeutic interventions that improve endothelial function is important for preventing diabetic vascular complications. Various hypoglycemic drugs and agents like GLP-1 receptor agonists and SGLT2 inhibitors may improve endothelial function through multiple mechanisms independent of glucose control or insulin signaling.
Review
Biochemistry & Molecular Biology
Jorge Gutierrez-Cuevas, Arturo Santos, Juan Armendariz-Borunda
Summary: Obesity is a global epidemic associated with various comorbidities, such as MAFLD, NASH, and CVD, with T2D being a common link between MAFLD/NASH and CVD. Understanding the underlying pathophysiological mechanisms is crucial for developing effective strategies to prevent and treat these diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Clinical Neurology
Xuhuan Tang, Fang Zheng
Summary: COVID-19, as the third type of coronavirus pneumonia after SARS and MERS, is associated with a high risk of ischemic stroke. The main mechanisms contributing to this risk are nerve invasion and endothelial dysfunction caused by the virus.
NEUROLOGICAL SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Vinit Agnihotri, Yogeeta Agrawal, Sameer Goyal, Charu Sharma, Shreesh Ojha
Summary: This review demonstrates the pathological changes that should be taken into account when targeting the pulmonary endothelial vasculature, especially with regard to inhaled particle deposition in the alveolar vasculature and characteristic formulations.
Review
Biochemistry & Molecular Biology
Jingwei Li, Yun Zhou, Jiechao Ma, Qin Zhang, Jun Shao, Shufan Liang, Yizhou Yu, Weimin Li, Chengdi Wang
Summary: COVID-19 may lead to long-term symptoms in multiple systems, referred to as long COVID, and can impact patients of varying severity. This comprehensive review highlights the epidemiology, impact of vaccinations, organ-specific sequelae, pathophysiological mechanisms, and multidisciplinary management strategies of long COVID, with emphasis on psychological and psychosomatic factors. Current diagnostic and therapeutic strategies are inadequate, and further clinical trials are needed to validate existing hypotheses.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2023)
Review
Biochemistry & Molecular Biology
Yin Liang, Mengxue Wang, Chen Wang, Yun Liu, Keiji Naruse, Ken Takahashi
Summary: Lifestyle changes can increase the risk of prediabetes, and the pathophysiology of atherosclerosis may progress even before the onset of diabetic symptoms. Changes in platelets and leukocytes, damage to vascular endothelial cells, as well as involvement of extracellular vesicles and microRNAs have been found to play a role in the progression of prediabetes atherosclerosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Anamaria Jurcau
Summary: Huntington's disease is an inherited neurodegenerative disease that primarily affects medium spiny neurons in the striatum. The mutant huntingtin protein leads to neuronal loss through a series of molecular cascades, involving excitotoxicity, transcriptional dysregulation, and other key factors. In addition to neurons, astrocytes are also dysfunctional due to the presence of mutant huntingtin, and neuroinflammation may further contribute to the pathogenesis of Huntington's disease.
Article
Cardiac & Cardiovascular Systems
Zhangjing Ma, Kevin Y. Yang, Yu Huang, Kathy O. Lui
Summary: This article reviews the clinical characteristics of COVID-19 associated endothelial dysfunction, as well as the likely pathological mechanisms such as direct cell entry or indirect immune overreactions after SARS-CoV-2 infection. It also discusses potential biomarkers indicating disease severity, particularly related to abnormal thrombosis development in severe COVID-19, a fatal vascular complication. Furthermore, it summarizes clinical trials targeting the direct and indirect pathological pathways after SARS-CoV-2 infection to prevent or inhibit virus-induced endothelial disorders.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2022)
Review
Immunology
Andrea De Lorenzo, Vanessa Estato, Hugo C. Castro-Faria-Neto, Eduardo Tibirica
Summary: The association between obesity and COVID-19 severity has been documented, with obese patients at higher risk of complications and mortality. Inflammation plays a central role in obesity, while metabolic alterations and chronic vascular endothelial dysfunction may contribute to worse outcomes in COVID-19 for obese individuals.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Medicine, General & Internal
S. C. Butcher, F. Fortuni, M. F. Dietz, E. A. Prihadi, P. van Der Bijl, N. Ajmone Marsan, J. J. Bax, V. Delgado
Summary: Severe right ventricular dysfunction was independently associated with significant renal impairment, and worse renal function was associated with a significant reduction in survival.
JOURNAL OF INTERNAL MEDICINE
(2021)
Review
Cardiac & Cardiovascular Systems
Hadis Shakeri, Katrien Lemmens, Andreas B. Gevaert, Guido R. Y. De Meyer, Vincent F. M. Segers
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2018)
Article
Cardiac & Cardiovascular Systems
Hadis Shakeri, Andreas B. Gevaert, Dorien M. Schrijvers, Guido R. Y. De Meyer, Gilles W. De Keulenaer, Pieter-Jan D. F. Guns, Katrien Lemmens, Vincent F. Segers
CARDIOVASCULAR RESEARCH
(2018)
Article
Public, Environmental & Occupational Health
Tiffany Naets, Leentje Vervoort, Marijke Ysebaert, Annelies Van Eyck, Stijn Verhulst, Luc Bruyndonckx, Benedicte De Winter, Kim Van Hoorenbeeck, Ann Tanghe, Caroline Braet
Letter
Cardiac & Cardiovascular Systems
Andreas B. Gevaert, Paul J. Beckers, Amaryllis H. Van Craenenbroeck, Katrien Lemmens, Caroline M. Van De Heyning, Hein Heidbuchel, Christiaan J. Vrints, Emeline M. Van Craenenbroeck
EUROPEAN JOURNAL OF HEART FAILURE
(2019)
Article
Multidisciplinary Sciences
Sarang Meybosch, Amandine De Monie, Charlotte Anne, Luc Bruyndonckx, Angelika Juergens, Benedicte Y. De Winter, Dominique Trouet, Kristien J. Ledeganck
Editorial Material
Cardiac & Cardiovascular Systems
Luc Bruyndonckx, Lucia J. M. Kroft, Vincent Bekker, Arno A. W. Roest, Roel L. F. van der Palen
PEDIATRIC CARDIOLOGY
(2019)
Article
Nutrition & Dietetics
Eline Vermeiren, Marijke Ysebaert, Kim Van Hoorenbeeck, Luc Bruyndonckx, Kristof Van Dessel, Maria Van Helvoirt, Ann De Guchtenaere, Benedicte De Winter, Stijn Verhulst, Annelies Van Eyck
Summary: Obesity and age can affect the reliability of DEXA and BIS measurements. This study compared the two methods in evaluating body composition in obese children before and after weight loss. Results showed that while BIS is a viable alternative to DEXA for group-level obesity studies, it is not superior for monitoring individual changes.
EUROPEAN JOURNAL OF CLINICAL NUTRITION
(2021)
Editorial Material
Cardiac & Cardiovascular Systems
Luc Bruyndonckx, Marta de Riva Silva, Nico A. Blom, Robin A. Bertels
Article
Genetics & Heredity
Luc Bruyndonckx, Judith L. Vogelzang, Marianna Bugiani, Bart Straver, Irene M. Kuipers, Wes Onland, Eline A. Nannenberg, Sally-Ann Clur, Saskia N. van der Crabben
Summary: This study describes two cases of pediatric cardiac disease with different clinical spectrums, a boy with mild DCM and a girl with fatal neonatal DCM, both associated with variants in the NEXN gene. These cases highlight the importance of investigating the NEXN gene in pediatric patients with DCM, even in cases with transient DCM.
AMERICAN JOURNAL OF MEDICAL GENETICS PART A
(2021)
Review
Cardiac & Cardiovascular Systems
Eline Vermeiren, Luc Bruyndonckx, Benedicte De Winter, Stijn Verhulst, Annelies Van Eyck, Kim Van Hoorenbeeck
Summary: This study examined the impact of weight regain on cardiometabolic health in children with obesity, finding that some indicators either recovered or continued to improve after weight regain. However, research in this area is limited.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2021)
Article
Clinical Neurology
Sofie Jacobs, Emilie Mylemans, Marijke Ysebaert, Eline Vermeiren, Ann De Guchtenaere, Hilde Heuten, Luc Bruyndonckx, Benedicte Y. De Winter, Kim Van Hoorenbeeck, Stijn L. Verhulst, Annelies Van Eyck
Summary: This study investigated the effect of weight loss on endothelial function and OSA in obese children, finding that weight loss significantly improved endothelial function. However, even after weight loss, the improvement in endothelial function was less pronounced in patients with OSA.
Article
Cardiac & Cardiovascular Systems
Massimo Stefano Silvetti, Luc Bruyndonckx, Alice Maltret, Roman Gebauer, Joanna Kwiatkowska, Laszlo Kornyei, Sonia Albanese, Cristina Raimondo, Christian Paech, Maciej Kempa, Gabor Fesus, Reinoud E. Knops, Nico Andreas Blom, Fabrizio Drago
Summary: This study aims to investigate the indications, complications, and outcomes of subcutaneous-implantable cardiac defibrillators (S-ICDs) in young patients. The results showed that S-ICDs had good efficacy and safety in young patients, with better outcomes in patients with BMI > 20 and newer implantation techniques.
Editorial Material
Cardiac & Cardiovascular Systems
Hielko Miljoen, Luc Bruyndonckx
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Genetics & Heredity
Laia Brunet-Garcia, Pirasuja Prabaharan, Luc Bruyndonckx, Ella Field, Felice DArco, Claudio Capelli, Elena Cervi
Summary: This study investigated the differences in tortuosity index (TI) between genotypes of LDS and found that patients with LDS and TGFBR2 variants have greater values of TI. The greatest values of TI are associated with increased aortic root z-scores. As time progresses, TI decreases and less frequent follow-up can be considered.
AMERICAN JOURNAL OF MEDICAL GENETICS PART A
(2023)
Article
Psychology, Clinical
Tiffany Naets, Eline Vermeiren, Leentje Vervoort, Annelies Van Eyck, Marijke Ysebaert, Stijn Verhulst, Benedicte De Winter, Kim Van Hoorenbeeck, Luc Bruyndonckx, Ann Tanghe, Ann De Guchtenaere, Sandra Verbeken, Caroline Braet
Summary: Research suggests that self-control may play a role in promoting healthy behavior and weight loss. This study investigated the effectiveness of Brain Fitness training as a supplement to inpatient obesity treatment in Belgian children and adolescents. While improvements were observed in inhibitory control and external eating over time, there was no significant interaction between time and condition. Future research should consider individual variability in self-control, sham training, and the real-life implications for children and adolescents with weight problems.
BEHAVIOUR RESEARCH AND THERAPY
(2023)