Article
Immunology
Kiriakos Koukoulias, Penelope-Georgia Papayanni, Aphrodite Georgakopoulou, Maria Alvanou, Stamatia Laidou, Anastasios Kouimtzidis, Chrysoula Pantazi, Glykeria Gkoliou, Timoleon-Achilleas Vyzantiadis, Alexandros Spyridonidis, Antonios Makris, Anastasia Chatzidimitriou, Nikoletta Psatha, Achilles Anagnostopoulos, Evangelia Yannaki, Anastasia Papadopoulou
Summary: A new steroid-resistant T-cell product, Cb-STs, targeting multiple pathogens has been rapidly generated using CRISPR/CAS9 technology, offering broad benefits for patients, particularly those in need of high-dose steroid treatment.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Guang-Qiang Meng, Jing-Shi Wang, Yi-Ni Wang, Na Wei, Zhao Wang
Summary: These findings suggest that rituximab-containing regimens are effective in treating EBV-HLH patients with predominately B cell infection, especially for eliminating EBV. However, the treatment may not be as effective for patients with T and NK cell predominated EBV infection.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Oncology
Thomas Pfeiffer, Ifigeneia Tzannou, Mengfen Wu, Carlos Ramos, Ghadir Sasa, Caridad Martinez, Premal Lulla, Robert A. Krance, Lauren Scherer, Daniel Ruderfer, Swati Naik, Claire Bocchini, Iain P. Fraser, Badrish Patel, Dany Ward, Tao Wang, Helen E. Heslop, Ann M. Leen, Bilal Omer
Summary: This study aimed to evaluate the feasibility and safety of posoleucel in allo-HCT recipients infected with viral infections. The results showed that posoleucel had good tolerability and achieved significant efficacy in treating multiple viral infections.
CLINICAL CANCER RESEARCH
(2023)
Article
Virology
Mohamed Ridha, Dylan G. Jones, David P. Lerner, Michal Vytopil, Barbara Voetsch, Joseph D. Burns, Anil Ramineni, Pooja Raibagkar
Summary: EBV-related neurologic complications following solid organ transplant can present in various syndromes, posing challenges in diagnosis. Careful correlation of clinical, pathologic, and radiologic findings is crucial for appropriate management in post-transplant patients.
Article
Medicine, General & Internal
Karima Al-Akioui Sanz, Carlos Echecopar Parente, Cristina Ferreras, Marta Menendez Ribes, Alfonso Navarro, Carmen Mestre, Laura Clares, Jose Luis Vicario, Antonio Balas, Raquel De Paz, Eduardo Lopez Granados, Elena Sanchez Zapardiel, Carlos Jimenez, Maria Lopez-Oliva, Esther Ramos, Francisco Hernandez-Oliveros, Antonio Perez-Martinez
Summary: Immunocompromised patients are susceptible to high-risk opportunistic infections and malignant diseases. Transfer of pathogen-specific memory T-cells has shown effectiveness in treating infections, but regulatory issues, high cost, and absence of public cell banks limit its use. CD45RA(-) cells containing memory T-cells offer a cheaper and safer alternative. Preliminary data from six patients showed that infusions of CD45RA(-) cells led to pathogen clearance, symptom resolution, and increased lymphocyte count.
FRONTIERS IN MEDICINE
(2023)
Article
Hematology
Hannes Vietzen, Philippe L. Furlano, Jan J. Cornelissen, Georg A. Boehmig, Peter Jaksch, Elisabeth Puchhammer-Stoeckl
Summary: This study found that nonclassic human leukocyte antigen E (HLA-E)-restricted immune responses have a significant impact on the development of Epstein-Barr virus (EBV) diseases in the individual host. The highly expressed HLA-E*0103/0103 genotype is protective against infectious mononucleosis (IM) by inducing potent EBV BZLF1-specific HLA-E-restricted CD8(+) T-cell responses. Variations in the inhibitory NKG2A/LMP-1/HLA-E axis are associated with the risk of symptomatic EBV reactivations in both immunocompetent individuals and immunocompromised transplant recipients.
Article
Medicine, General & Internal
Austin Feindt, Montserrat Lara-Velazquez, Ahmad Alkhasawneh, Dinesh Rao, Raafat Makary, Keith Dombrowski, Daryoush Tavanaiepour, Gazanfar Rahmathulla
Summary: This case report presents a 72-year-old female patient who had undergone renal transplant 11 years ago and developed progressively worsening headaches and confusion. Imaging revealed brain edema in the frontal and temporal lobes. Surgical biopsy confirmed a diagnosis of Polymorphic PTLD. Early diagnosis is crucial for patient survival with PTLD.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Infectious Diseases
Julian Lindsay, Jad Othman, Madeleine R. Heldman, Monica A. Slavin
Summary: Management of EBV PTLD involves complex measures such as risk stratification, preemptive therapy, and balancing treatment options. Experimental therapies like donor-derived multipathogen and EBV specific CTLs show promise in prevention and treatment of EBV PTLD.
CURRENT OPINION IN INFECTIOUS DISEASES
(2021)
Article
Immunology
Oded Shamriz, Deepak Kumar, Jenny Shim, Michael Briones, Maa-Ohui Quarmyne, Satheesh Chonat, Laura Lucas, Holly Edington, Michael H. White, Advay Mahajan, Sunita Park, Shanmuganathan Chandrakasan
Summary: T cell-EBV-HLH is found in the USA, especially among non-Asian populations such as Hispanics. Most patients do not have primary HLH gene defects, but disease severity and treatment response are correlated. The majority of patients respond well to immunosuppressive therapy.
JOURNAL OF CLINICAL IMMUNOLOGY
(2021)
Review
Microbiology
Wen Liu, Yan Zhang, Bing Luo
Summary: This review summarizes current findings regarding lncRNAs involved in cancers caused by Epstein-Barr virus (EBV) and Kaposi's sarcoma herpesvirus (KSHV). Additionally, it discusses the contribution of lncRNAs to tumor occurrence, development, invasion, and metastasis; the roles of lncRNAs in key signaling pathways; and their potential as biomarkers and therapeutic targets for tumor diagnostics and treatment.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Clinical Neurology
Daisuke Sato, Hirokazu Takami, Shunsaku Takayanagi, Kazuki Taoka, Mariko Tanaka, Reiko Matsuura, Shota Tanaka, Nobuhito Saito
Summary: This is the first report documenting the development of other iatrogenic immunodeficiency-associated lymphoproliferative disorder (OIIA-LPD) during temozolomide therapy. Timely diagnosis of the disease and discontinuation of temozolomide were considered to be the preferred management. Close monitoring for relapse should be continued.
Article
Medicine, General & Internal
Masayo Yamamoto, Motohiro Shindo, Chihiro Sumi, Sho Igarashi, Takeshi Saito, Nodoka Tsukada, Yasumichi Toki, Mayumi Hatayama, Junki Inamura, Kazuya Sato, Yusuke Mizukami, Yoshihiro Torimoto, Toshikatsu Okumura
Summary: The case presented a 69-year-old male patient who developed acquired hemophilia A (AHA) during treatment for Epstein-Barr-virus-associated T/natural killer-cell lymphoproliferative disease (EBV-T/NK-LPD). The patient's AHA improved with higher dose prednisolone treatment, achieving complete remission after 13 months of low-dose prednisolone maintenance. It is speculated that EBV-infected and proliferating monoclonal NK cells might have modulated the immune system and produced autoantibodies against factor VIII, leading to the development of AHA in this patient with EBV-T/NK-LPD.
Review
Immunology
Hui Zhang, Shuliang Zhao, Zhijun Cao
Summary: EBV infection may lead to severe complications in IBD patients, highlighting the importance of screening and monitoring; immunosuppressive therapy may increase the susceptibility of IBD patients to EBV infection; withdrawal of immunosuppressants may be helpful in achieving remission in diseases caused by EBV infection.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Dermatology
Ryan Fan, Catherine Baker, Earl J. Glusac, Mina L. Xu, Alejandro A. Gru, Jeffrey M. Cohen
Summary: Primary, acute Epstein-Barr virus (EBV) infection can cause various skin eruptions, including viral exanthem and erythema multiforme. Chronic latent EBV infection rarely leads to lymphoproliferative disorders with cutaneous manifestations, but these disorders do not arise from primary infection. This report presents a case of primary, acute EBV infection with histopathologic features closely resembling aggressive cytotoxic cutaneous T-cell lymphoma.
JOURNAL OF CUTANEOUS PATHOLOGY
(2023)
Article
Oncology
Masahiro Nomura, Ryusuke Sumiya, Hayato Ono, Takeshi Nagai, Keigo Kumazawa, Atsushi Shimizu, Daisuke Endo, Nobuyoshi Aoyanagi
Summary: This case report describes an 81-year-old female patient with rheumatoid arthritis who developed a jejunum perforation induced by MTX-LPD. After undergoing emergency surgery and stopping MTX treatment, the patient experienced disease remission without the need for chemotherapy. EBV-positive patients, especially those with a pathological presentation of EBVMCU, may have a higher likelihood of remission. Further research is needed to evaluate the clinicopathological features of MTX-LPD.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2021)
