Article
Behavioral Sciences
Nasya Thompson, Michael MacAskill, Maddie Pascoe, Tim Anderson, Campbell Le Heron
Summary: This study investigates the multidimensional pattern of apathy in individuals with Parkinson's disease (PD) using the Apathy Motivation Index (AMI), which explores behavioral, emotional, and social aspects of apathy. The results show that individuals with PD exhibit higher levels of behavioral and social apathy, but lower levels of emotional apathy. The study also demonstrates the connection between apathy and other non-motor comorbidities such as depression and anxiety. The findings highlight the importance of considering apathy as a multidimensional construct in clinical and research settings.
BRAIN AND BEHAVIOR
(2023)
Article
Clinical Neurology
Samuel Yong-Ern Ng, Nicole Shuang-Yu Chia, Mirza Masoom Abbas, Ehsan Seyed Saffari, Xinyi Choi, Dede Liana Heng, Zheyu Xu, Kay-Yaw Tay, Wing-Lok Au, Eng-King Tan, Louis Chew-Seng Tan
Summary: The study found that higher baseline physical activity in early PD patients was associated with younger age, lower MDS-UPDRS motor scores, smaller levodopa equivalent daily dose, better attention and memory scores, and better quality of life. Additionally, it was revealed that higher baseline physical activity was associated with decreased anxiety and apathy scores at 1-year follow-up.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Harry Costello, Yumeya Yamamori, Suzanne Reeves, Anette-Eleonore Schrag, Robert Howard, Jonathan P. Roiser
Summary: This study found that dopaminergic dysfunction in the midbrain is associated with motivational symptoms such as apathy and anhedonia in Parkinson's disease (PD), and this association becomes evident as the disease progresses. These findings can inform intervention strategies for improving the treatment of PD patients.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Review
Neurosciences
Segolene De Waele, Patrick Cras, David Crosiers
Summary: This article summarizes the research findings on apathy in Parkinson's disease, discusses the prevalence rates and screening tools, formulates patient-tailored treatment recommendations, and explores the clinical manifestations and prognosis of the Park apathy phenotype. It aims to provide a clinical and patient-oriented perspective on the vast theoretical knowledge available.
Article
Clinical Neurology
Alfonsina D'Iorio, Chiara Baiano, Giovanna Maraucci, Carmine Vitale, Marianna Amboni, Gabriella Santangelo
Summary: The COVID-19 pandemic has affected the mental health of PD patients. The study found that self-isolation at home during the pandemic may lead to a reduction in apathy and anhedonia in PD patients due to increased social support.
NEUROLOGICAL SCIENCES
(2022)
Article
Clinical Neurology
Jaime Kulisevsky, Saul Martinez-Horta, Antonia Campolongo, Berta Pascual-Sedano, Juan Marin-Lahoz, Helena Bejr-kasem, Ignacio Aracil-Bolanos, Andrea Horta-Barba, Arnau Puig-Davi, Javier Pagonabarraga
Summary: The study aimed to investigate the effects of safinamide on apathy in Parkinson's disease (PD) patients. The results showed no sufficient evidence to support the improvement of apathy with safinamide, although a positive trend was observed in the post-hoc analysis. Safinamide exhibited good safety profile and tolerability during the treatment period. Larger studies are needed to further validate this trend.
FRONTIERS IN NEUROLOGY
(2022)
Article
Neurosciences
Marina Picillo, David-Erick Lafontant, Susan Bressman, Chelsea Caspell-Garcia, Christopher Coffey, Hyunkeun Ryan Cho, Elliot L. Burghardt, Nabila Dahodwala, Rachel Saunders-Pullman, Caroline M. Tanner, Amy W. Amara
Summary: Men with early untreated Parkinson's disease (PD) showed greater longitudinal changes in motor and non-motor features compared to women. They also required higher dopaminergic medication dosages over time. However, there were no sex-related progression patterns observed in biological biomarkers.
JOURNAL OF PARKINSONS DISEASE
(2022)
Article
Clinical Neurology
Lee-Anne Morris, Samuel J. Harrison, Tracy R. Melzer, John C. Dalrymple-Alford, Tim J. Anderson, Michael R. MacAskill, Campbell J. Le Heron
Summary: Morris et al. found that apathy in Parkinson's disease is associated with changes in functional connectivity and structural changes in the nucleus accumbens and anterior cingulate cortex, providing a potential causal pathway to loss of motivation. Their study demonstrates that disruption to key nodes within a network involved in motivated behavior may lead to the development of apathy. These findings suggest the possibility of identifying individuals at risk for apathy before the onset of motivational deficits.
Review
Neurosciences
Cristina del Toro Perez, Laura Amaya Pascasio, Antonio Arjona Padillo, Jesus Olivares Romero, Maria Victoria Mejias Olmedo, Javier Fernandez Perez, Manuel Payan Ortiz, Patricia Martinez-Sanchez
Summary: Literature research demonstrates that brainstem raphe hypoechogenicity is related to depression in both PD and non-PD patients, as well as overactive bladder. Substantia nigra hyperechogenicity is common in patients with visual hallucinations, and larger intracranial ventricles are correlated with dementia. The evaluation of the vagus nerve shows contradictory findings.
Article
Biochemistry & Molecular Biology
Ramesh Pariyar, Tonking Bastola, Dae Ho Lee, Jungwon Seo
Summary: The anti-diabetic drug vildagliptin has been found to have protective effects against motor dysfunction caused by Parkinson's disease (PD), potentially through the regulation of PI3k/Akt, ERK, and JNK signaling pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Tracy D. Zhang, Scott C. Kolbe, Leah C. Beauchamp, Ella K. Woodbridge, David I. Finkelstein, Emma L. Burrows
Summary: The prodromal phase of Parkinson's disease is characterized by several non-motor symptoms, which have been suggested to be predictive of later diagnosis. Genetic rodent models can develop non-motor phenotypes, with gastrointestinal dysfunction being the most reproducible phenotype. However, inconsistencies in phenotypes among rodent models pose a challenge in translatability, and future research should focus on improving experimental design to enhance phenotype reproducibility.
Article
Psychiatry
Ian H. Kratter, Ahmed Jorge, Michael T. Feyder, Ashley C. Whiteman, Yue-fang Chang, Luke C. Henry, Jordan F. Karp, R. Mark Richardson
Summary: This study investigates the potential impact of psychiatric history on the relationship between active contact location and neuropsychological outcomes following deep brain stimulation of the subthalamic nucleus. The results suggest that a history of depression may influence this relationship, with these patients being more sensitive to off-target stimulation.
TRANSLATIONAL PSYCHIATRY
(2022)
Article
Pharmacology & Pharmacy
Yang Li, Qiao Yin, Bing Wang, Tingting Shen, Weifeng Luo, Tong Liu
Summary: Reserpine can induce motor and non-motor symptoms of Parkinson's disease (PD) by affecting the expression of α-synuclein through DNA methylation and autophagic impairment.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Clinical Neurology
Konstantin G. Heimrich, Aline Schonenberg, Hannah M. Muehlhammer, Sarah Mendorf, Diego Santos-Garcia, Tino Prell
Summary: This study aimed to determine the impact of non-motor symptoms on the progression of Parkinson's disease and revealed that the depressive symptoms of anhedonia and feeling sad had the strongest influence on the overall pattern of non-motor symptoms in PD.
FRONTIERS IN NEUROLOGY
(2023)
Article
Geriatrics & Gerontology
Sarah M. Szymkowicz, Jacob D. Jones, Holly Timblin, Cameron A. Ryczek, Warren D. Taylor, Pamela E. May
Summary: This study found that worsening depressive symptoms over time in patients with PD may be a risk factor for increased apathy and subsequent decline in specific cognitive functions.
AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY
(2022)
Letter
Clinical Neurology
Heidi Foo, Kok Pin Ng, Jayne Tan, Lina Lim, Russell Jude Chander, Ting Ting Yong, Nagaendran Kandiah
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2018)
Article
Clinical Neurology
Chathuri Yatawara, Kok Pin Ng, Russell Chander, Nagaendran Kandiah
Article
Cell Biology
Russell Jude Chander, Heidi Foo, Tingting Yong, Levinia Lim, Jayne Tan, Ming-Ching Wen, Adeline Ng, Shahul Hameed, Simon Ting, Juan Zhou, Nagaendran Kandiah
Article
Geriatrics & Gerontology
Chathuri Yatawara, Daryl Lee, Kok Pin Ng, Russell Chander, Debby Ng, Fang Ji, Hee Youn Shim, Saima Hilal, Narayanaswamy Venketasubramanian, Christopher Chen, Juan Zhou, Nagaendran Kandiah
AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY
(2019)
Article
Geriatrics & Gerontology
Chathuri Yatawara, Kok Pin Ng, Levinia Lim, Russell Chander, Juan Zhou, Nagaendran Kandiah
AMERICAN JOURNAL OF ALZHEIMERS DISEASE AND OTHER DEMENTIAS
(2019)
Meeting Abstract
Clinical Neurology
Viral Upadhyay, Aloysius Ng, Manori Wijayath
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2019)
Article
Endocrinology & Metabolism
Aloysius Ng, Anthony Liu, Ralph Nanan
JOURNAL OF DIABETES
(2020)
Article
Neurosciences
Audrey Low, Kok Pin Ng, Russell Jude Chander, Benjamin Wong, Nagaendran Kandiah
JOURNAL OF ALZHEIMERS DISEASE
(2019)
Article
Clinical Neurology
Jessica W. Lo, John D. Crawford, David W. Desmond, Olivier Godefroy, Hanna Jokinen, Simin Mahinrad, Hee-Joon Bae, Jae-Sung Lim, Sebastian Kohler, Elles Douven, Julie Staals, Christopher Chen, Xin Xu, Eddie J. Chong, Rufus O. Akinyemi, Rajesh N. Kalaria, Adesola Ogunniyi, Melanie Barbay, Martine Roussel, Byung-Chul Lee, Velandai K. Srikanth, Christopher Moran, Nagaendran Kandiah, Russell J. Chander, Behnam Sabayan, J. Wouter Jukema, Susanna Melkas, Timo Erkinjuntti, Henry Brodaty, Regis Bordet, Stephanie Bombois, Hilde Henon, Darren M. Lipnicki, Nicole A. Kochan, Perminder S. Sachdev, Amy Brodtmann, Aleksandra Klimkowicz-Mrowiec, Martin Dichgans, Michael Hoffmann, Thomas Linden, Joanna Wardlaw, Charlotte Cordonnier, Vincent Mok
Article
Geriatrics & Gerontology
Lai Gwen Chan, Kimberly Sim Soon Siang, Ting Ting Yong, Russell Chander, Louis Tan, Nagaendran Kandiah
JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY
(2020)
Article
Clinical Neurology
Chathuri Yatawara, Anne Cristine Guevarra, Kok Pin Ng, Russell Chander, Bonnie Yin Ka Lam, Adrian Wong, Vincent Mok, Nagaendran Kandiah
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2020)
Article
Geriatrics & Gerontology
Russell J. Chander, Sarah A. Grainger, John D. Crawford, Karen A. Mather, Katya Numbers, Rhiagh Cleary, Nicole A. Kochan, Henry Brodaty, Julie D. Henry, Perminder S. Sachdev
INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
(2020)
Article
Medicine, General & Internal
Chun Seng Phua, Aloysius Ng, Christopher Brooks, Zinta Harrington, Hima Vedam, Thang Huynh, Desi Seccombe, Patrick Aouad, Dennis Cordato
Summary: The study analyzed the prevalence of advanced care directives (ACDs) in a MND clinic and found that one-quarter of patients completed ACDs. There was no significant correlation between ACD completion and factors such as age, gender, MND subtype, symptom duration, treatment modalities, and location of death. Further research is needed to understand the factors influencing patients' decisions regarding ACDs.
POSTGRADUATE MEDICAL JOURNAL
(2021)
Article
Clinical Neurology
Jessica W. Lo, John D. Crawford, Katherine Samaras, David W. Desmond, Sebastian Kohler, Julie Staals, Frans R. J. Verhey, Hee-Joon Bae, Keon-Joo Lee, Beom Joon Kim, Regis Bordet, Charlotte Cordonnier, Thibaut Dondaine, Anne-Marie Mendyk, Byung-Chul Lee, Kyung-Ho Yu, Jae-Sung Lim, Nagaendran Kandiah, Russell J. Chander, Chathuri Yatawara, Darren M. Lipnicki, Perminder S. Sachdev
Article
Emergency Medicine
Alan Fahey, Elinor Cripps, Aloysius Ng, Amy Sweeny, Peter J. Snelling
Summary: The study showed that PENG block can be safely and effectively administered to hip fracture patients in the ED. Inexperienced providers were able to perform the block successfully, and there were no significant differences in pain relief, adverse effects, and opioid use compared to other regional anesthesia methods.
EMERGENCY MEDICINE AUSTRALASIA
(2022)
Article
Clinical Neurology
Jun-Pyo Hong, Hanim Kwon, Euyhyun Park, Sun-Uk Lee, Chan-Nyoung Lee, Byung-Jo Kim, Ji-Soo Kim, Kun-Woo Park
Summary: In patients with mild-to-moderate PD, vestibular function assessed by video head-impulse tests appears relatively preserved and has minimal impact on the risk of falls. Risk of postural instability is associated with the severity of clinical symptoms in PD.
PARKINSONISM & RELATED DISORDERS
(2024)
Article
Clinical Neurology
Yaqin Xiang, XiuRong Huang, Qian Xu, Zhenhua Liu, Yase Chen, Qiying Sun, Junling Wang, Hong Jiang, Lu Shen, Xinxiang Yan, Beisha Tang, Jifeng Guo
Summary: Using the novel data-driven method DEBM, this study determined the sequence of several common biomarker changes in Parkinson's disease (PD). The left putamen was found to be the earliest biomarker to become abnormal, followed by the right putamen, CSF alpha-synuclein, right caudate, left caudate, and serum NfL. The estimated disease stages showed significant differences between PD and healthy controls, and achieved a high accuracy for distinguishing PD from HC.
PARKINSONISM & RELATED DISORDERS
(2024)
Article
Clinical Neurology
Yan Li, David J. McLernon, Carl E. Counsell, Angus D. Macleod
Summary: This study aimed to investigate the incidence and risk factors for institutionalisation in Parkinson's disease (PD) and atypical parkinsonism (AP). The study found that institutionalisation was more frequent in AP compared to PD and controls. Age, poorer cognition, and more-severe parkinsonian impairment were independent predictors of institutionalisation.
PARKINSONISM & RELATED DISORDERS
(2024)