Article
Clinical Neurology
Egle Audronyte, Vaiva Sutnikiene, Gyte Pakulaite-Kazliene, Gintaras Kaubrys
Summary: This study investigated olfactory memory and its relationship with verbal memory and other clinical features in patients with early-stage Alzheimer's disease (AD). The results showed that olfactory memory was significantly impaired in patients with AD compared to individuals with mild cognitive impairment due to AD and cognitively normal older participants. Furthermore, the duration of AD symptoms was a strong predictor of olfactory recognition memory scores.
FRONTIERS IN NEUROLOGY
(2023)
Article
Clinical Neurology
Mattia Siciliano, Rosa De Micco, Andrea Gerardo Russo, Fabrizio Esposito, Valeria Sant'Elia, Lucia Ricciardi, Francesca Morgante, Antonio Russo, Jennifer G. Goldman, Carlo Chiorri, Gioacchino Tedeschi, Luigi Trojano, Alessandro Tessitore
Summary: This study identified three distinct memory-related phenotypes in patients with mild cognitive impairment related to Parkinson's disease (PD-MCI) through cluster analysis. These phenotypes were associated with motor and non-motor features as well as patients' quality of life. The findings contribute to understanding the pathophysiological mechanisms underlying PD-MCI and its subtypes and guiding appropriate treatments.
MOVEMENT DISORDERS
(2023)
Review
Geriatrics & Gerontology
Rwei-Ling Yu, Ruey-Meei Wu
Summary: Mild cognitive impairment (MCI) is a common non-motor symptom in patients with Parkinson's disease (PD), but lacks consistent diagnostic criteria. Different types of cognitive impairments have different progression rates. This review provides an overview of the diagnostic criteria for PD-MCI and the heterogeneity of patients' cognitive function.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Neurosciences
Sara Becker, Olga Boettinger, Patricia Sulzer, Markus A. Hobert, Kathrin Brockmann, Walter Maetzler, Daniela Berg, Inga Liepelt-Scarfone
Summary: Through FAQ assessment, it was found that PD-MCI patients had more difficulties with tax records and traveling, while AD-MCI patients were more impaired in managing finances and remembering appointments. The classification accuracy of the FAQ differed between MCI related to PD and AD.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Clinical Neurology
Calogero Edoardo Cicero, Giulia Donzuso, Antonina Luca, Marco Davi, Roberta Baschi, Giovanni Mostile, Loretta Giuliano, Stefano Palmucci, Andrea Salerno, Roberto Monastero, Alessandra Nicoletti, Mario Zappia
Summary: This study found that Parkinson's disease patients with mild cognitive impairment showed midbrain atrophy and thinning of the frontal cortical regions on MRI scans. These findings may serve as structural MRI features of Parkinson's disease patients with cognitive impairment.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Geriatrics & Gerontology
Marianna Amboni, Carlo Ricciardi, Sofia Cuoco, Leandro Donisi, Antonio Volzone, Gianluca Ricciardelli, Maria Teresa Pellecchia, Gabriella Santangelo, Mario Cesarelli, Paolo Barone
Summary: This study aimed to compare gait patterns in PD-MCI subtypes to verify the association between specific gait features and particular MCI subtypes. The results showed that gait patterns were poorer in PD-MCI patients compared to those without MCI, and multiple-domain PD-MCI and amnestic PD-MCI were associated with worse gait patterns.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Neurosciences
Chenxi Pan, Jingru Ren, Ping Hua, Lei Yan, Miao Yu, Yajie Wang, Gaiyan Zhou, Ronggui Zhang, Jiu Chen, Weiguo Liu
Summary: SCCs are common in early PD patients, with distinct prevalence and risk factors between PD-MCI and PD-NC patients.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Geriatrics & Gerontology
Min Cai, Ge Dang, Xiaolin Su, Lin Zhu, Xue Shi, Sixuan Che, Xiaoyong Lan, Xiaoguang Luo, Yi Guo
Summary: Cognitive impairment is common in patients with Parkinson's disease (PD) and is associated with altered functional connectivity patterns in the theta frequency bands of brain regions such as the PMFG. Abnormal functional connectivity in PMFG may serve as reliable biomarkers for identifying cognitive impairment in PD patients.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Clinical Neurology
Kun Nie, Yanyi Li, Jiahui Zhang, Yuyuan Gao, Yihui Qiu, Rong Gan, Yuhu Zhang, Lijuan Wang
Summary: This study found that there are different bile acid profiles between patients with PD-MCI and PD-NC. Lower levels of CDCA, CA, and UDCA were significantly associated with PD-MCI and may be distinct bile acid signatures for patients with PD-MCI.
FRONTIERS IN NEUROLOGY
(2022)
Article
Neurosciences
Xiao Deng, Seyed Ehsan Saffari, Samuel Yong Ern Ng, Nicole Chia, Jayne Yi Tan, Xinyi Choi, Dede Liana Heng, Zheyu Xu, Kay-Yaw Tay, Wing-Lok Au, Nan Liu, Adeline Ng, Eng-King Tan, Louis C. S. Tan
Summary: This study found that PD patients had significantly lower levels of lipid biomarkers, while PD-MCI patients had higher levels of TC, TG, and Apo A1. TC, TG, and Apo A1 may be useful biomarkers for PD-MCI.
JOURNAL OF PARKINSONS DISEASE
(2022)
Article
Geriatrics & Gerontology
Sung Hoon Kang, Jinhee Kim, Jungyeun Lee, Seong-Beom Koh
Summary: Cognitive impairment is often accompanied by gait disturbance in patients with Parkinson's disease (PD). This study aimed to investigate the association between gait parameters and mild cognitive impairment (MCI), as well as the correlation between performance on comprehensive neuropsychological tests and gait parameters in PD patients. The results showed that gait velocity and stride length were associated with MCI in PD patients, and these gait parameters were primarily influenced by attention and frontal-executive function.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jiahui Zhang, Yuyuan Gao, Xuetao He, Shujun Feng, Jinlong Hu, Qingxi Zhang, Jiehao Zhao, Zhiheng Huang, Limin Wang, Guixian Ma, Yuhu Zhang, Kun Nie, Lijuan Wang
Summary: PD-MCI is characterized by widespread structural and EEG abnormalities. Composite markers could be valuable for the individualized diagnosis of PD-MCI through machine learning. The SVM model based on qEEG and structural MR features showed high accuracy in identifying PD-MCI.
EUROPEAN RADIOLOGY
(2021)
Article
Clinical Neurology
Shiloh L. Echevarria-Cooper, Emily H. Ho, Richard C. Gershon, Sandra Weintraub, Thorsten Kahnt
Summary: Olfactory decline is associated with aging, amnestic mild cognitive impairment (aMCI), and Alzheimer's disease dementia. The National Institutes of Health Toolbox Odor Identification Test (NIHTB-OIT) can distinguish between these clinical categories. The scores of NIHTB-OIT decrease with age and are lower for aMCI and ADd participants compared to NC participants.
ALZHEIMERS & DEMENTIA
(2023)
Article
Geriatrics & Gerontology
Ai Che Yap, Rathi Mahendran, Ee Heok Kua, Weibiao Zhou, De Yun Wang
Summary: This study found that olfactory identification impairment is a comorbidity in older adults with amnestic MCI and is a potential marker associated with an early stage of neurocognitive disorder. The smell test could serve as a screening tool to help in the early detection of smell impairment for heterogeneous syndromes of MCI among community-dwelling older adults.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Neurosciences
Xueling Suo, Du Lei, Nannan Li, Jiaxin Peng, Chaolan Chen, Wenbin Li, Kun Qin, Graham J. Kemp, Rong Peng, Qiyong Gong
Summary: This study investigates the relationship between mild cognitive impairment in early-stage Parkinson's disease (PD-M) and whole-brain functional networks. The results show that there are abnormal connections in the brain functional networks of PD-M patients, which may be related to their increased risk of dementia.
Article
Clinical Neurology
W. Narita, Y. Nishio, T. Baba, O. Iizuka, T. Ishihara, M. Matsuda, M. Iwasaki, T. Tominaga, E. Mori
AMERICAN JOURNAL OF NEURORADIOLOGY
(2016)
Article
Medicine, General & Internal
Akio Kikuchi, Atsushi Takeda, Naoto Sugeno, Emiko Miura, Kazuhiro Kato, Takafumi Hasegawa, Toru Baba, Masatoshi Konno, Ryuji Oshima, Shoichi Watanuki, Kotaro Hiraoka, Manabu Tashiro, Masashi Aoki
Article
Medicine, General & Internal
Toru Baba, Shigenori Kanno, Tomomi Shijo, Yoshiyuki Nishio, Osamu Iizuka, Naoto Kamimura, Tomonori Ishii, Etsuro Mori
Article
Clinical Neurology
Yoshiyuki Nishio, Kayoko Yokoi, Makoto Uchiyama, Yasuyuki Mamiya, Hiroyuki Watanabe, Miyeong Gang, Toru Baba, Atsushi Takeda, Kazumi Hirayama, Etsuro Mori
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2017)
Article
Clinical Neurology
Toru Baba, Yoshiyuki Hosokai, Yoshiyuki Nishio, Akio Kikuchi, Kazumi Hirayama, Kyoko Suzuki, Takafumi Hasegawa, Masashi Aoki, Atsushi Takeda, Etsuro Mori
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2017)
Review
Medicine, General & Internal
Takafumi Hasegawa, Naoto Sugeno, Akio Kikuchi, Toru Baba, Masashi Aoki
TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE
(2017)
Article
Biochemistry & Molecular Biology
Shun Yoshida, Takafumi Hasegawa, Mari Suzuki, Naoto Sugeno, Junpei Kobayashi, Morio Ueyama, Mitsunori Fukuda, Akemi Ido-Fujibayashi, Kiyotoshi Sekiguchi, Michinori Ezura, Akio Kikuchi, Toru Baba, Atsushi Takeda, Hideki Mochizuki, Yoshitaka Nagai, Masashi Aoki
HUMAN MOLECULAR GENETICS
(2018)
Article
Clinical Neurology
Yoshiyuki Nishio, Kayoko Yokoi, Kazumi Hirayama, Toshiyuki Ishioka, Yoshiyuki Hosokai, Miyeong Gang, Makoto Uschiyama, Toru Baba, Kyoko Suzuki, Atsushi Takeda, Etsuro Mori
PARKINSONISM & RELATED DISORDERS
(2018)
Article
Multidisciplinary Sciences
Hiroyuki Watanabe, Yoshiyuki Nishio, Yasuyuki Mamiya, Wataru Narita, Osamu Iizuka, Toru Baba, Atsushi Takeda, Tatsuo Shimomura, Etsuro Mori
Article
Geriatrics & Gerontology
Hiroyuki Watanabe, Minoru Matsuda, Shoko Ota, Toru Baba, Osamu Iizuka, Etsuro Mori
Article
Geriatrics & Gerontology
Hiroyuki Watanabe, Minoru Matsuda, Shoko Ota, Toru Baba, Osamu Iizuka, Etsuro Mori
Article
Clinical Neurology
Nobuhito Abe, Iori Kawasaki, Hiroaki Hosokawa, Toru Baba, Atsushi Takeda
FRONTIERS IN NEUROLOGY
(2018)
Article
Clinical Neurology
Miyeong Gang, Toru Baba, Yoshiyuki Hosokai, Yoshiyuki Nishio, Akio Kikuchi, Kazumi Hirayama, Takafumi Hasegawa, Masashi Aoki, Atsushi Takeda, Etsuro Mori, Kyoko Suzuki
MOVEMENT DISORDERS
(2020)
Article
Otorhinolaryngology
Ai Kawamoto-Hirano, Ryoukichi Ikeda, Toshiaki Takahashi, Sayaka Taniguchi, Masaru Yoshioka, Hiroyasu Tanaka, Hideki Oizumi, Tomoko Totsune, Saki Oshiro, Toru Baba, Atsushi Takeda, Yuta Kobayashi, Jun Ohta, Yukio Katori
Summary: The usefulness of RSST, MWST, and FEES in evaluating the swallowing function and predicting the risk of aspiration pneumonia in patients with DMD was examined. Combining MWST and FEES is useful for evaluating the bedside swallowing function and predicting the onset of pneumonia.
AURIS NASUS LARYNX
(2023)
Review
Clinical Neurology
Toru Baba, Atsushi Takeda
NEUROLOGY AND CLINICAL NEUROSCIENCE
(2020)
Article
Clinical Neurology
Jun-Pyo Hong, Hanim Kwon, Euyhyun Park, Sun-Uk Lee, Chan-Nyoung Lee, Byung-Jo Kim, Ji-Soo Kim, Kun-Woo Park
Summary: In patients with mild-to-moderate PD, vestibular function assessed by video head-impulse tests appears relatively preserved and has minimal impact on the risk of falls. Risk of postural instability is associated with the severity of clinical symptoms in PD.
PARKINSONISM & RELATED DISORDERS
(2024)
Article
Clinical Neurology
Yaqin Xiang, XiuRong Huang, Qian Xu, Zhenhua Liu, Yase Chen, Qiying Sun, Junling Wang, Hong Jiang, Lu Shen, Xinxiang Yan, Beisha Tang, Jifeng Guo
Summary: Using the novel data-driven method DEBM, this study determined the sequence of several common biomarker changes in Parkinson's disease (PD). The left putamen was found to be the earliest biomarker to become abnormal, followed by the right putamen, CSF alpha-synuclein, right caudate, left caudate, and serum NfL. The estimated disease stages showed significant differences between PD and healthy controls, and achieved a high accuracy for distinguishing PD from HC.
PARKINSONISM & RELATED DISORDERS
(2024)
Article
Clinical Neurology
Yan Li, David J. McLernon, Carl E. Counsell, Angus D. Macleod
Summary: This study aimed to investigate the incidence and risk factors for institutionalisation in Parkinson's disease (PD) and atypical parkinsonism (AP). The study found that institutionalisation was more frequent in AP compared to PD and controls. Age, poorer cognition, and more-severe parkinsonian impairment were independent predictors of institutionalisation.
PARKINSONISM & RELATED DISORDERS
(2024)