Journal
PARKINSONISM & RELATED DISORDERS
Volume 30, Issue -, Pages 62-66Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.parkreldis.2016.05.028
Keywords
Parkinson's disease; Impulse control disorders; I-123-FP-CIT imaging; Statistical parametric mapping; Functional covariance analysis
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Background: Impulse Control Disorder symptoms (ICD) in Parkinson's disease (PD) has been recently associated by magnetic Resonance imaging with impaired cortico-striatal connectivity, especially between left putamen and frontal associative areas. Methods: 84 patients entered the study (21 PD-ICD+ and 64 PD-ICD-) and underwent DATSCAN imaging. The striatal tracer uptake was evaluated using BRASS software (Hermes, Sweden). The whole-brain analysis was performed with Statistical Parametric Mapping (SPM). Results: PD-ICD+ showed a significant reduction of left putaminal and left inferior frontal gyrus tracer uptake compared to PD-ICD-. Functional covariance analysis using left putamen as the seed point showed that, in contrast to ICD-patients, ICD+ patients had no functional covariance with contralateral basal ganglia and ipsilateral cingulate cortex, as index of an impaired inter- and intra-hemispheric dopamine binding in PD-ICD+. Discussion: the results support and expand the concept of a functional disconnection syndrome linked to ICD symptoms in PD patients through an asymmetric molecular frontostriatal network breakdown with left basal ganglia as central hub. (C) 2016 Elsevier Ltd. All rights reserved.
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