Article
Immunology
Alma Reyna Escalona-Montano, Mariana Zuniga-Fabian, Nallely Cabrera, Ricardo Mondragon-Flores, Jenny Nancy Gomez-Sandoval, Araceli Rojas-Bernabe, Augusto Gonzalez-Canto, Laila Gutierrez-Kobeh, Ruy Perez-Montfort, Ingeborg Becker, Maria Magdalena Aguirre-Garcia
Summary: In this study, the researchers cloned and characterized the structure and function of PP2C in Leishmania, finding that LmxPP2C exhibited protein dephosphorylation activity under specific conditions. Immunodetection showed its localization in the flagellar structures of the protozoan, suggesting a potentially important role in specific cellular processes.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Immunology
Erich Loza Telleria, Bruno Tinoco-Nunes, David M. Forrest, Tatiana Di-Blasi, Tereza Lestinova, Kwang Poo Chang, Petr Volf, Andre Nobrega Pitaluga, Yara Maria Traub-Cseko
Summary: This study investigated the expression of genes involved in regulating the Toll pathway in Lutzomyia longipalpis under parasitic infection. The results showed that Leishmania infantum infection upregulated the expression of two genes, suggesting that the parasite can modulate the sand fly's immune response. Moreover, the increased expressions of sand fly SHP and parasite GP63 were connected.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Guy Sobol, Joydeep Chakraborty, Gregory B. Martin, Guido Sessa
Summary: The antagonistic effect of plant immunity on growth has driven the evolution of molecular mechanisms to prevent accidental initiation and prolonged activation of plant immune responses. Protein phosphatases, particularly PP2C phosphatases, play a key role in regulating the signaling networks of plant immunity. Harnessing immunity-associated PP2Cs has the potential to enhance plant disease resistance.
MOLECULAR PLANT-MICROBE INTERACTIONS
(2022)
Article
Microbiology
Exequiel O. Porta, Liqian Gao, Paul W. Denny, Patrick G. Steel, Karunakaran Kalesh
Summary: This study systematically characterizes the perturbing effect of HSP90 inhibition on the phosphoproteome of Leishmania mexicana, revealing distinct molecular effects in different life cycle stages. The findings provide insight into selective molecular targeting in the therapeutically relevant amastigote stage.
MICROBIOLOGY SPECTRUM
(2023)
Article
Immunology
Jovana Sadlova, Lucie Podesvova, Tomas Becvar, Claretta Bianchi, Evgeny S. Gerasimov, Andreu Saura, Kristyna Glanzova, Tereza Lestinova, Nadezhda S. Matveeva, Lubomira Chmelova, Denisa Mlacovska, Tatiana Spitzova, Barbora Vojtkova, Petr Volf, Vyacheslav Yurchenko, Natalya Kraeva
Summary: Research shows that expressing catalase in Leishmania parasites severely compromises their ability to develop in insects, be transmitted, infect mice, and cause clinical manifestation in mammalian hosts. This suggests that the presence of catalase is not compatible with the dixenous life cycle of Leishmania.
Article
Chemistry, Multidisciplinary
Jinmin Miao, Jiajun Dong, Yiming Miao, Yunpeng Bai, Zihan Qu, Brenson A. Jassim, Bo Huang, Quyen Nguyen, Yuan Ma, Allison A. Murray, Jinyue Li, Philip S. Low, Zhong-Yin Zhang
Summary: In this study, researchers discovered the first highly potent and selective TC-PTP degrader called TP1L, which can induce degradation of TC-PTP and enhance T-cell signaling and tumor killing efficacy.
Article
Multidisciplinary Sciences
Greta Volpedo, Thalia Pacheco-Fernandez, Timur Gannavaram, Hannah L. Markle, Nazli Azodi, Shinjiro Hamano, Greg Matlashewski, Sreenivas Gannavaram, Hira L. Nakhasi, Abhay R. Satoskar
Summary: Leishmaniasis is a prevalent tropical disease for which there is currently no approved human vaccine. In this study, a live attenuated L. mexicana strain was developed and shown to induce a strong immune response in mice. The research also revealed the important role of the pentose phosphate pathway in the immune mechanism of protection.
Article
Biochemistry & Molecular Biology
Yu Chen, Haohan Zhao, Yue Wang, Xiaojun Qiu, Gang Gao, Aiguo Zhu, Ping Chen, Xiaofei Wang, Kunmei Chen, Jia Chen, Peng Chen, Jikang Chen
Summary: In this study, 63 BnPP2C genes were identified and classified in the ramie genome. The study revealed that BnPP2C1 and BnPP2C26 could be candidate genes for drought and salt tolerance in ramie. These findings are important for further understanding the function of PP2C genes and the stress response mechanism in ramie.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cell Biology
Francisca Cornejo, Bastian I. Cortes, Greg M. Findlay, Gonzalo I. Cancino
Summary: Protein phosphatases are key regulators of signal transduction, with the LAR-RPTP subfamily playing an important role in neurobiology, from neurodevelopment to brain disorders. The LAR-RPTP subfamily consists of three members in vertebrates and is involved in various brain functions.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Alexander Drilon, Manish R. Sharma, Melissa L. Johnson, Timothy A. Yap, Shirish Gadgeel, Dale Nepert, Gang Feng, Micaela B. Reddy, Allison S. Harney, Mohamed Elsayed, Adam W. Cook, Christina E. Wong, Ronald J. Hinklin, Yutong Jiang, Eric N. Brown, Nickolas A. Neitzel, Ellen R. Laird, Wen - Wu, Anurag Singh, Ping Wei, Keith A. Ching, John J. Gaudino, Patrice A. Lee, Dylan P. Hartley, S. Michael Rothenberg
Summary: PF-07284892, an allosteric SHP2 inhibitor, combined with various oncogenic driver inhibitors, overcame bypass-signaling-mediated resistance in clinical settings. This combination therapy showed significant tumor and circulating tumor DNA responses, extending the duration of overall clinical benefit in patients with targeted therapy resistance in lung, colorectal, ovarian, and pancreatic cancer.
Article
Multidisciplinary Sciences
Aretha Chan, Jose-Mauricio Ayala, Fernando Alvarez, Ciriaco Piccirillo, George Dong, David Langlais, Martin Olivier
Summary: This study analyzed the early innate inflammatory events during L. major infection, confirming the significant role of the virulence factor GP63 in providing favorable conditions for host cell infection. The data suggest that GP63 does not greatly influence pathogen-induced inflammatory cell recruitment, but rather affects their activation status and effector function, as well as potentially influencing the internalization of promastigotes during early infection.
Review
Biochemistry & Molecular Biology
Salin Kiratikanon, Siriporn C. Chattipakorn, Nipon Chattipakorn, Sirinart Kumfu
Summary: Protein tyrosine phosphatase non-receptor type 6 (PTPN6) is a crucial regulatory protein in cellular signal transduction, controlling inflammation and cell death. This article summarizes the relationship between PTPN6 and neutrophilic dermatosis, discusses its regulatory mechanisms, and summarizes treatment options.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2022)
Article
Virology
Hong-Shuai Gao, Rong-Min Hu, Ze-Hua Wang, Xi-Qian Ye, Xiao-Tong Wu, Jian-Hua Huang, Zhi-Zhi Wang, Xue-Xin Chen
Summary: In this study, a PTP gene, CvBV_12-6, derived from CvBV was characterized and found to negatively regulate the immune response in the host P. xylostella. It suppressed the phenoloxidase activity and antibacterial abilities of hemocytes, as well as reduced the host's melanization and viability.
Article
Multidisciplinary Sciences
Suad Gazi Jaafer Husaine Al Kufi, Josiah Emmerson, Heidi Rosenqvist, Catarina Mateus Moreira Garcia, Diana Onodelia Rios-Szwed, Martin Wiese
Summary: Kinesins, including LmxKIN29, play important roles in cell division, intracellular organization, and flagellum formation and maintenance. The study suggests that LmxKIN29 is a potential drug target for leishmaniasis based on its crucial role in the disease and its divergence from mammalian kinesins.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Jingying Chen, Jizhuo Li, Hong Sun, Tianyi Hu, Yameng Wang, Guoqi Kang, Mingya Cao, Xia Li
Summary: The p38 MAP kinase signaling pathway plays a critical role in cancer cells by sensing and adapting to environmental stimuli. This study reveals a negative regulator, PPM1G, that is highly expressed in lung adenocarcinoma and correlates with poor prognosis. PPM1G dephosphorylates MEK6 to reduce p38 phosphorylation, contributing to the proliferation, invasion, and metastasis of lung adenocarcinoma.
Article
Cell Biology
Fabrizio Rinaldi, Yu Zhang, Ricardo Mondragon-Gonzalez, Jeffrey Harvey, Rita C. R. Perlingeiro
Article
Cell Biology
Ricardo Mondragon-Gonzalez, Rita C. R. Perlingeiro
DISEASE MODELS & MECHANISMS
(2018)
Article
Immunology
Lucia A. Mendez-Garcia, Fernanda Trejo-Millan, Camilo P. Martinez-Reyes, Aaron N. Manjarrez-Reyna, Marcela Esquivel-Velazquez, Guillermo Melendez-Mier, Sergio Islas-Andrade, Araceli Rojas-Bernabe, Julia Kzhyshkowska, Galileo Escobedo
SCANDINAVIAN JOURNAL OF IMMUNOLOGY
(2018)
Article
Multidisciplinary Sciences
Viridiana Gracida-Jimenez, Ricardo Mondragon-Gonzalez, Griselda Velez-Aguilera, Alejandra Vasquez-Limeta, Marco S. Laredo-Cisneros, Juan de Dios Gomez-Lopez, Luis Vaca, Sarah C. Gourlay, Laura A. Jacobs, Steve J. Winder, Bulmaro Cisneros
SCIENTIFIC REPORTS
(2017)
Article
Cell Biology
Paulina Margarita Azuara-Medina, Ariana Maria Sandoval-Duarte, Sara L. Morales-Lazaro, Ricardo Modragon-Gonzalez, Griselda Velez-Aguilera, Juan de Dios Gomez-Lopez, Guadalupe Elizabeth Jimenez-Gutierrez, Reynaldo Tiburcio-Felix, Ivette Martinez-Vieyra, Rocio Suarez-Sanchez, Gernot Laengst, Jonathan Javier Magana, Steve J. Winder, Arturo Ortega, Rita de Cassia Ramos Perlingeiro, Laura A. Jacobs, Bulmaro Cisneros
CELL DEATH & DISEASE
(2019)
Article
Biochemistry & Molecular Biology
Alessandro Magli, June Baik, Lauren J. Mills, Il-Youp Kwak, Bridget S. Dillon, Ricardo Mondragon Gonzalez, David A. Stafford, Scott A. Swanson, Ron Stewart, James A. Thomson, Daniel J. Garry, Brian D. Dynlacht, Rita C. R. Perlingeiro
Article
Respiratory System
Juan Manuel Bello-Lopez, Gregorio Leon-Garcia, Araceli Rojas-Bernabe, V. Fernandez-Sanchez, Omar Garcia-Hernandez, Javier Mancilla Ramirez, Gabriela Ibanez-Cervantes
CANADIAN RESPIRATORY JOURNAL
(2019)
Article
Parasitology
Ruben Dario Diaz-Martin, Corinne Mercier, Carmen T. Gomez de Leon, Ricardo Mondragon Gonzalez, Sirenia Gonzalez Pozos, Emmanuel Rios-Castro, Raul Arguello Garcia, Barbara A. Fox, David J. Bzik, Ricardo Mondragon Flores
PARASITOLOGY RESEARCH
(2019)
Article
Biotechnology & Applied Microbiology
Sridhar Selvaraj, Neha R. Dhoke, James Kiley, Alba Judith Mateos-Aierdi, Sudheer Tungtur, Ricardo Mondragon-Gonzalez, Grace Killeen, Vanessa K. P. Oliveira, Adolfo Lopez de Munain, Rita C. R. Perlingeiro
Article
Cell Biology
Tea Shavlakadze, Melody Morris, Jian Fang, Sharon X. Wang, Jiang Zhu, Weihua Zhou, Herman W. Tse, Ricardo Mondragon-Gonzalez, Guglielmo Roma, David J. Glass
Article
Medicine, General & Internal
Ricardo Mondragon-Gonzalez, Karim Azzag, Sridhar Selvaraj, Ami Yamamoto, Rita C. R. Perlingeiro
Article
Biology
Sridhar Selvaraj, Ricardo Mondragon-Gonzalez, Bin Xu, Alessandro Magli, Hyunkee Kim, Jeanne Laine, James Kiley, Holly Mckee, Fabrizio Rinaldi, Joy Aho, Nacira Tabti, Wei Shen, Rita C. R. Perlingeiro
Article
Public, Environmental & Occupational Health
G. Ibanez-Cervantes, G. Leon-Garcia, C. Vargas-De-Leon, G. Castro-Escarpulli, C. Bandala, O. Sosa-Hernandez, J. Mancilla-Ramirez, A. Rojas-Bernabe, M. A. Cureno-Diaz, E. M. Duran-Manuel, C. Cruz-Cruz, J. C. Bravata-Alcantara, D. Juarez-Ascencio, J. M. Bello-Lopez
Article
Immunology
Alma Reyna Escalona-Montano, Mariana Zuniga-Fabian, Nallely Cabrera, Ricardo Mondragon-Flores, Jenny Nancy Gomez-Sandoval, Araceli Rojas-Bernabe, Augusto Gonzalez-Canto, Laila Gutierrez-Kobeh, Ruy Perez-Montfort, Ingeborg Becker, Maria Magdalena Aguirre-Garcia
Summary: In this study, the researchers cloned and characterized the structure and function of PP2C in Leishmania, finding that LmxPP2C exhibited protein dephosphorylation activity under specific conditions. Immunodetection showed its localization in the flagellar structures of the protozoan, suggesting a potentially important role in specific cellular processes.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Espiridion Ramos-Martinez, Jorge Rojas-Serrano, Warrison Andrade, Araceli Rojas-Bernabe, Ramces Falfan-Valencia, Gloria Perez-Rubio, Rosa Campos-Gutierrez, Ruben Cruz-Pantoja, Andrea Velasco-Medina, Guillermo Velazquez-Samano
Summary: The study explored the relationship between different asthma phenotypes and their specific characteristics, finding that allergic, non-allergic, and obese patients were the main phenotypes with overlapping features. Allergic asthma patients showed high levels of leukotrienes and IgE, while non-allergic asthma patients had a narrow ratio between IL-18 and IL-18 binding protein.