Why calpain inhibitors are interesting leading compounds to search for new therapeutic options to treat leishmaniasis?

Rational Design of Calpain Inhibitors Based on Calpastatin Peptidomimetics

(2016) Kristin E. Low et al.   JOURNAL OF MEDICINAL CHEMISTRY

ERRATUM

(2015)   MEMORIAS DO INSTITUTO OSWALDO CRUZ

Incentives to Repurpose Existing Drugs for Orphan Indications

(2015) Annette K. Kwok et al.   ACS Medicinal Chemistry Letters

New perspectives for leishmaniasis chemotherapy over current anti-leishmanial drugs: a patent landscape

(2014) Alice Machado-Silva et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Modulation of a cytoskeletal calpain-like protein induces major transitions in trypanosome morphology

(2014) Polly Hayes et al.   JOURNAL OF CELL BIOLOGY

The Calpain Inhibitor MDL28170 Induces the Expression of Apoptotic Markers in Leishmania amazonensis Promastigotes

(2014) Fernanda A. Marinho et al.   PLoS One

Calpains: Potential Targets for Alternative Chemotherapeutic Intervention Against Human Pathogenic Trypanosomatids

(2013) M. Branquinha et al.   CURRENT MEDICINAL CHEMISTRY

Miltefosine: a review of its pharmacology and therapeutic efficacy in the treatment of leishmaniasis

(2012) T. P. C. Dorlo et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Leishmaniasis Worldwide and Global Estimates of Its Incidence

(2012) Jorge Alvar et al.   PLoS One

Synthesis of chromone carboxamide derivatives with antioxidative and calpain inhibitory properties

(2011) Sang Hoon Kim et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Calpain inhibitors: a survey of compounds reported in the patent and scientific literature

(2011) Isaac O Donkor   EXPERT OPINION ON THERAPEUTIC PATENTS

MDL28170, a Calpain Inhibitor, Affects Trypanosoma cruzi Metacyclogenesis, Ultrastructure and Attachment to Rhodnius prolixus Midgut

(2011) Vítor Ennes-Vidal et al.   PLoS One

Calpain chronicle—an enzyme family under multidisciplinary characterization

(2011) Hiroyuki SORIMACHI et al.   PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES

Socio–economic aspects of neglected diseases: sleeping sickness and visceral leishmaniasis

(2010) M. Boelaert et al.   ANNALS OF TROPICAL MEDICINE AND PARASITOLOGY

Molecular Modeling Studies of Peptide Inhibitors Highlight the Importance of Conformational Prearrangement for Inhibition of Calpain

(2010) Wanting Jiao et al.   BIOCHEMISTRY

Effects of the calpain inhibitor MDL28170 on the clinically relevant forms of Trypanosoma cruzi in vitro

(2010) V. Ennes-Vidal et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Promiscuous drugs as therapeutics for chemokine receptors

(2009) Richard Horuk   EXPERT REVIEWS IN MOLECULAR MEDICINE

Neglected Tropical Diseases: Multi-Target-Directed Ligands in the Search for Novel Lead Candidates againstTrypanosomaandLeishmania

(2009) Andrea Cavalli et al.   JOURNAL OF MEDICINAL CHEMISTRY

Arrested growth of Trypanosoma cruzi by the calpain inhibitor MDL28170 and detection of calpain homologues in epimastigote forms

(2009) L. S. SANGENITO et al.   PARASITOLOGY