Article
Biology
Casandra Panea, Ruoyu Zhang, Jeffrey VanValkenburgh, Min Ni, Christina Adler, Yi Wei, Francisca Ochoa, Jennifer Schmahl, Yajun Tang, Chia-Jen Siao, William Poueymirou, Jennifer Espert, Wei Keat Lim, Gurinder S. Atwal, Andrew J. Murphy, Matthew A. Sleeman, Zaruhi Hovhannisyan, Sokol Haxhinasto
Summary: Panea et al. demonstrated that Btnl2 plays a crucial role in maintaining homeostasis of gamma delta IELs in the ileum by suppressing their proliferation. Btnl2 deficiency affects TCR specificities and diversity of ileal gamma delta IELs, leading to increased inflammation and delayed mucosal repair in the colon during DSS-induced colitis, highlighting the immunological importance of Btnl2 in intestinal diseases.
COMMUNICATIONS BIOLOGY
(2021)
Article
Parasitology
Willem Landman, Olivier Verneau, Miguel Vences, Louis du Preez
Summary: This study aims to formally describe a previously undescribed polystome species infecting Aglyptodactylus madagascariensis, which was discovered through dissection of frogs from museum collections and parasite surveys conducted in Madagascar.
ACTA PARASITOLOGICA
(2023)
Article
Chemistry, Multidisciplinary
Shuchang Lai, Ying Chen, Fan Yang, Weidi Xiao, Yuan Liu, Chu Wang
Summary: Protein lipoylation is an important post-translational modification related to various human diseases. However, a comprehensive strategy for quantifying lipoylation sites is still lacking. In this study, we developed a novel approach to quantify lipoylation sites in complex biological samples and investigated their functional connection with the synthetic pathway. This research will contribute to the understanding of the molecular mechanisms underlying lipoylation-related diseases.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Chemistry, Multidisciplinary
Takumi Okuda, Ann-Kathrin Lenz, Florian Seitz, Joerg Vogel, Claudia Hoebartner
Summary: Post-transcriptional RNA modification is a powerful method for site-specific RNA labelling and analysis of RNA functions. A ribozyme called SAMURI has been developed that can catalyse the transfer of a propargyl group to a specific adenosine on the target RNA within cells, offering a general tool for site-specific RNA labelling that can be further functionalized.
Article
Biochemical Research Methods
Thaiesha A. Wright, Monica Sharfin Rahman, Camaryn Bennett, Madolynn R. Johnson, Henry Fischesser, Natasha Ram, Amoni Tyler, Richard C. Page, Dominik Konkolewicz
Summary: This study presents a novel strategy for site-specific protein conjugation using hydrolytically stable amide-based maleimides for long-term stability. Ester groups are better suited for systems that require debonding of polymers over time.
BIOCONJUGATE CHEMISTRY
(2021)
Article
Multidisciplinary Sciences
Sisi Jia, Siew Cheng Phua, Yuta Nihongaki, Yizeng Li, Michael Pacella, Yi Li, Abdul M. Mohammed, Sean Sun, Takanari Inoue, Rebecca Schulman
Summary: Mesoscale molecular assemblies on the cell surface integrate information and amplify signals. Here the authors integrate DNA nanotubes in a controlled manner with mammalian cells to act as sheer stress meters.
NATURE COMMUNICATIONS
(2021)
Article
Ecology
Olivier Rieppel
Summary: The modern discussion of living fossils focuses on the persistent presence of ancient or ancestral traits in current organisms. Examples include the platypus and lungfishes. Identifying these traits requires comparing phylogenetic relationships, based on shared derived characters, rather than just the persistence of ancient traits. The occurrence of both primitive and advanced traits in a species is called the heterobathmy of characters.
FRONTIERS IN ECOLOGY AND EVOLUTION
(2023)
Article
Parasitology
Samuel J. Leeming, Christoph Hahn, Stephan Koblmueller, Chris T. McAllister, Maarten P. M. Vanhove, Nikol Kmentova
Summary: Polystomatidae is a family of parasites that infect (semi)-aquatic tetrapods, with Sphyranura being a genus that parasitizes salamander hosts. This study identified S. euryceae as the species infecting Oklahoma salamander based on morphological examination, type material comparison, and the first molecular data. The genetic similarity between S. euryceae and S. oligorchis suggests a close relationship, and mitochondrial comparisons revealed tRNA gene rearrangements in polystomatids. The phylogenetic position of Sphyranura within the polystomatid lineage remains unresolved.
Article
Chemistry, Multidisciplinary
Xiao-Kun Zhang, Hong-Ming Yang, Meng-Ran Li, Xiao-Yi Gao, Xiao-Wei Sun, Xi-Feng Sun, Jin-Bao Tang
Summary: The study introduces a new method for orienting antibodies on the surface of liposomes, enhancing the detection efficiency of novel immunoliposomes with Fc region-specific and covalent conjugation for prostate-specific antigen. The immunoliposomes showed a significantly improved detection sensitivity, making them potential for sensitive detection of various biomarkers in complex serum samples.
Article
Psychology, Multidisciplinary
Katarina Greskovicova, Elena Lisa
Summary: This study aimed to explore the importance of specific adult attachments in the working setting and their associations with organizational variables. The results showed that work-specific attachment models differ from romantic attachment models and also vary among themselves. Depending on attachment to colleagues, two attachment orientations (secure and insecure) can be distinguished among working adults. Fostering secure attachment at work may lead to positive outcomes in terms of performance and relationships.
FRONTIERS IN PSYCHOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Fredrik Noborn, Jonas Nilsson, Goran Larson
Summary: Proteoglycans are carbohydrate-modified proteins present in metazoan organisms. Their glycosaminoglycan (GAG) chains play important functional roles, but the detailed understanding of their structure and function is limited. Mass-spectrometric analysis provides site-specific information on proteoglycans and reveals their structural complexity. Combining functional assays with mass-spectrometric techniques can expand our understanding of proteoglycan function.
Article
Parasitology
Amira Chaabane, Louis Du Preez, Gerald R. Johnston, Olivier Verneau
Summary: In this study, we re-evaluated the systematic status of polystomes through the reexamination of specimens and molecular phylogenetic analysis. We found that Neopolystoma and Polystomoides were not monophyletic and proposed to assign all species to the genus Polystomoides, with nine new combinations. However, based on its unique morphological features, we suggested keeping Uteropolystomoides as a valid taxon.
Article
Parasitology
Olivier Verneau, Gerald R. Johnston, Louis Du Preez
Summary: This study focuses on the origin of a parasitic worm, Oculotrema hippopotami, which infects the conjunctival sacs of common hippopotamuses. Molecular phylogenetic analysis revealed a close relationship between O. hippopotami and Apaloneotrema moleri, a parasite of the Florida softshell turtle. This suggests a lateral parasite transfer between freshwater turtles and hippopotamuses, highlighting an exceptional example of host-switching in vertebrate evolution.
INTERNATIONAL JOURNAL FOR PARASITOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Alexander K. Zinsmaier, Yan Dong, Yanhua H. Huang
Summary: Cocaine craving, seeking, and relapse are partially mediated by adaptive changes in the brain reward circuits induced by cocaine. The nucleus accumbens integrates emotional and motivational inputs and prioritizes them for the reward system. Medium spiny neurons in the NAc show complex adaptations following cocaine experience, influenced by various factors such as cocaine regimen, withdrawal time, cell type, location, and input/output projections.
MOLECULAR PSYCHIATRY
(2022)
Review
Biochemistry & Molecular Biology
Alexei F. Kisselev
Summary: Proteasome is a crucial protein degradation machine in maintaining protein homeostasis and regulating cell functions. FDA-approved proteasome inhibitors are used for multiple myeloma treatment. Various inhibitors target different active sites of the proteasome, impacting its biological functions and identifying potential drug targets for disease treatment.
Article
Biodiversity Conservation
Jessica J. Scriven, Lucy C. Woodall, Matthew C. Tinsley, Mairi I. E. Knight, Paul H. Williams, James C. Carolan, Mark J. F. Brown, Dave Goulson
BIOLOGICAL CONSERVATION
(2015)
Editorial Material
Biology
Andrew D. M. Dobson, Stuart K. J. R. Auld, Matthew C. Tinsley
Editorial Material
Biology
Stineke van Houte, Monique M. van Oers, Yue Han, Just M. Vlak, Vera I. D. Ros
Article
Geriatrics & Gerontology
Cristina V. Ariani, Punita Juneja, Sophia Smith, Matthew C. Tinsley, Francis M. Jiggins
EXPERIMENTAL GERONTOLOGY
(2015)
Article
Ecology
T. M. Houslay, J. Hunt, M. C. Tinsley, L. F. Bussiere
JOURNAL OF EVOLUTIONARY BIOLOGY
(2015)
Article
Biodiversity Conservation
Helen E. Roy, Peter M. J. Brown, Tim Adriaens, Nick Berkvens, Isabel Borges, Susana Clusella-Trullas, Richard F. Comont, Patrick De Clercq, Rene Eschen, Arnaud Estoup, Edward W. Evans, Benoit Facon, Mary M. Gardiner, Artur Gil, Audrey A. Grez, Thomas Guillemaud, Danny Haelewaters, Annette Herz, Alois Honek, Andy G. Howe, Cang Hui, William D. Hutchison, Marc Kenis, Robert L. Koch, Jan Kulfan, Lori Lawson Handley, Eric Lombaert, Antoon Loomans, John Losey, Alexander O. Lukashuk, Dirk Maes, Alexandra Magro, Katie M. Murray, Gilles San Martin, Zdenka Martinkova, Ingrid A. Minnaar, Oldrich Nedved, Marina J. Orlova-Bienkowskaja, Naoya Osawa, Wolfgang Rabitsch, Hans Peter Ravn, Gabriele Rondoni, Steph L. Rorke, Sergey K. Ryndevich, May-Guri Saethre, John J. Sloggett, Antonio Onofre Soares, Riaan Stals, Matthew C. Tinsley, Axel Vandereycken, Paul van Wielink, Sandra Viglasova, Peter Zach, Ilya A. Zakharov, Tania Zaviezo, Zihua Zhao
BIOLOGICAL INVASIONS
(2016)
Article
Multidisciplinary Sciences
Jessica J. Scriven, Penelope R. Whitehorn, Dave Goulson, Matthew C. Tinsley
Article
Biology
Stuart K. J. R. Auld, Shona K. Tinkler, Matthew C. Tinsley
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2016)
Article
Ecology
Jessica J. Scriven, Penelope R. Whitehorn, Dave Goulson, Matthew. C. Tinsley
ECOLOGY AND EVOLUTION
(2016)
Review
Ecology
S. K. J. R. Auld, M. C. Tinsley
Article
Multidisciplinary Sciences
Marco Kubiak, Matthew C. Tinsley
SCIENTIFIC REPORTS
(2017)
Article
Biology
Katherine E. Raines, Penelope R. Whitehorn, David Copplestone, Matthew C. Tinsley
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2020)
Article
Microbiology
David J. Pascall, Matthew C. Tinsley, Bethany L. Clark, Darren J. Obbard, Lena Wilfert
Summary: This study investigates the diversity of newly discovered bumblebee viruses in Scotland and finds that they are more genetically diverse than viruses shared with honeybees. The presence of multiple infections and environmental factors such as temperature and UV radiation play important roles in shaping viral prevalence. This research represents an initial step in understanding predictors of bumblebee infection in the wild.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Ecology
Jessica E. Burrows, David Copplestone, Katherine E. Raines, Nicholas A. Beresford, Matthew C. Tinsley
Summary: This study investigates the impact of radiation on bumblebees' energy budgets. The results show that chronic low-dose radiation increases nectar consumption, metabolic CO2 production, and activity time in bumblebees. The study reveals that radiation exposure can alter energy metabolism in bumblebees and have significant effects on downstream life-history traits.
FUNCTIONAL ECOLOGY
(2022)