Do schistosome vaccine trials in mice have an intrinsic flaw that generates spurious protection data?

Induction of vascular leak syndrome by tumor necrosis factor-alpha alone

(2015) Kyung-Yeon Park et al.   BIOMEDICINE & PHARMACOTHERAPY

Accelerated Evolution of Schistosome Genes Coding for Proteins Located at the Host–Parasite Interface

(2015) Gisele S. Philippsen et al.   Genome Biology and Evolution

What’s in SWAP? Abundance of the principal constituents in a soluble extract of Schistosoma mansoni revealed by shotgun proteomics

(2015) Leandro Xavier Neves et al.   Parasites & Vectors

Sm29, but Not Sm22.6 Retains its Ability to Induce a Protective Immune Response in Mice Previously Exposed to a Schistosoma mansoni Infection

(2015) Clarice Carvalho Alves et al.   PLoS Neglected Tropical Diseases

Protective Potential of Antioxidant Enzymes as Vaccines for Schistosomiasis in a Non-Human Primate Model

(2015) Claudia Carvalho-Queiroz et al.   Frontiers in Immunology

Two SmDLC antigens as potential vaccines against schistosomiasis

(2014) Patricia Placoná Diniz et al.   ACTA TROPICA

Combination of the two schistosomal antigens Sm14 and Sm29 elicits significant protection against experimental Schistosoma mansoni infection

(2014) Radwa E. Ewaisha et al.   EXPERIMENTAL PARASITOLOGY

A multivalent chimeric vaccine composed ofSchistosoma mansoniSmTSP-2 and Sm29 was able to induce protection against infection in mice

(2014) C. S. Pinheiro et al.   PARASITE IMMUNOLOGY

Cysteine Peptidases as Schistosomiasis Vaccines with Inbuilt Adjuvanticity

(2014) Rashika El Ridi et al.   PLoS One

Schistosome Syntenin Partially Protects Vaccinated Mice against Schistosoma mansoni Infection

(2014) Barbara C. Figueiredo et al.   PLoS Neglected Tropical Diseases

Fragility of pulmonary capillaries

(2013) John B. West   JOURNAL OF APPLIED PHYSIOLOGY

Vaccine-Induced Protection Against Murine Schistosomiasis Mansoni with Larval Excretory–Secretory Antigens and Papain or Type-2 Cytokines

(2013) Rashika El Ridi et al.   JOURNAL OF PARASITOLOGY

Efficacy and mechanism of action of arachidonic acid in the treatment of hamsters infected with Schistosoma mansoni or Schistosoma haematobium

(2012) Rashika El Ridi et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Lymph node targeting of BCG vaccines amplifies CD4 and CD8 T-cell responses and protection against Mycobacterium tuberculosis

(2012) Ying Waeckerle-Men et al.   VACCINE

Preclinical Prophylactic Efficacy Testing of Sm-p80–Based Vaccine in a Nonhuman Primate Model of Schistosoma mansoni Infection and Immunoglobulin G and E Responses to Sm-p80 in Human Serum Samples From an Area Where Schistosomiasis Is Endemic

(2011) Gul Ahmad et al.   JOURNAL OF INFECTIOUS DISEASES

Multiple vaccinations with UV- attenuated cercariae in pig enhance protective immunity against Schistosoma japonicum infection as compared to single vaccination

(2011) Dandan Lin et al.   Parasites & Vectors

Role of basophils in the initiation of Th2 responses

(2010) Caroline L Sokol et al.   CURRENT OPINION IN IMMUNOLOGY

Protein variation in blood-dwelling schistosome worms generated by differential splicing of micro-exon gene transcripts

(2010) R. DeMarco et al.   GENOME RESEARCH

Sm‐p80–Based DNA Vaccine Provides Baboons with Levels of Protection againstSchistosomamansoniInfection Comparable to Those Achieved by the Irradiated Cercarial Vaccine

(2010) Weidong Zhang et al.   JOURNAL OF INFECTIOUS DISEASES

Schistosoma japonicum-infected hamsters (Mesocricetus auratus) used as a model in experimental chemotherapy with praziquantel, artemether, and OZ compounds

(2010) Shu-hua Xiao et al.   PARASITOLOGY RESEARCH

Radiation-attenuated schistosome vaccination – a brief historical perspective

(2009) Q. D. BICKLE   PARASITOLOGY

The saga of schistosome migration and attrition

(2009) R. A. WILSON   PARASITOLOGY

Developmentally regulated expression, alternative splicing and distinct sub-groupings in members of the Schistosoma mansoni venom allergen-like (SmVAL) gene family

(2008) Iain W Chalmers et al.   BMC GENOMICS

Schistosoma mansoni Tegument Protein Sm29 Is Able to Induce a Th1-Type of Immune Response and Protection against Parasite Infection

(2008) Fernanda C. Cardoso et al.   PLoS Neglected Tropical Diseases