Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 21, Issue 15, Pages 5718-5722Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201500552
Keywords
amides; arylation; C-H activation; cobalt; tetrazoles
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Funding
- European Research Council under the European Community/ERC [307535]
- Chinese Scholarship Program
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Cobalt-catalyzed C-H arylations enabled the synthesis of biaryl tetrazoles, which are key structural motifs in antihypertensive angiotensin-II-receptor blockers. Thus, weakly-coordinating benzamides were employed for step-economical C-H arylations with ample scope. Further, a low-valent NHC complex enabled first cobalt-catalyzed C-H functionalization by tetrazole assistance.
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