Review
Biochemistry & Molecular Biology
Yair Sharav, Yaron Haviv, Rafael Benoliel
Summary: The purpose of this study is to explore the potential differences between orofacial migraine (OFM) and neurovascular orofacial pain (NVOP). Facial presentations of primary headache resemble primary headache disorders, but they occur in specific locations associated with the trigeminal nerve. The International Classification of Orofacial Pain, 1st edition (ICOP) classifies these conditions as orofacial pains resembling primary headaches, including OFM and NVOP. The subtle differences and similar response to therapy suggest a possible overlap between NVOP and OFM, and further investigations are needed to separate them into distinct entities.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Veterinary Sciences
Xiaoling Huang, Zhenxing Li, Jiahui Ma, Dong Huang, Xuebin Yan, Haocheng Zhou
Summary: The study introduced a novel electrical stimulator for the measurement of orofacial pain in freely behavioral rodents. The results showed that the stimulator accurately assessed both the sensory and affective components of orofacial pain.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Editorial Material
Biochemistry & Molecular Biology
Yoshizo Matsuka
Summary: The Special Issue Orofacial Pain: Molecular Mechanisms, Diagnosis, and Treatment 2021 is a collection of 6 articles published by 41 authors from different countries, focusing on various aspects of orofacial pain. The articles cover topics such as molecular mechanisms, diagnosis, and treatment options, and include studies on specific pain models and related biological factors, such as GABAergic neurons and ATP signaling. Additionally, a review paper on trigeminal neuralgia is included.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Dentistry, Oral Surgery & Medicine
F. Lobbezoo, G. Aarab, F. P. Kapos, A. F. Dayo, Z. Huang, M. Koutris, M. A. Peres, M. Thymi, B. Haggman-Henrikson
Summary: The World Health Organization has adopted a resolution emphasizing the need for global improvement in oral health, especially considering that untreated oral diseases are highly prevalent. Poor oral health often leads to orofacial pain, which is the primary reason for emergency dental visits worldwide. To make evidence-based decisions on oral health, reliable and valid assessment tools for orofacial pain complaints are necessary. The International Association for Dental Research's INfORM has been instrumental in developing comprehensive assessment tools, and further development and testing of brief, easy to translate, and culturally adaptable tools is needed for global implementation.
JOURNAL OF DENTAL RESEARCH
(2022)
Article
Behavioral Sciences
Dominik A. Ettlin, Marcelo Henrique Napimoga, Miguel Meira e Cruz, Juliana Trindade Clemente-Napimoga
Summary: Pain is a multifaceted experience, involving sensory, emotional, and cognitive dimensions. Orofacial musculoskeletal pain is influenced by various factors such as social burdens, coping strategies, mood states, and psychological disorders, requiring psychosocial assessments in diagnostic processes. Studies suggest a potential causal relationship between stress, bruxism, and masticatory pain, with brain structures playing key roles in pain modulation.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Article
Urology & Nephrology
Kelli Aibel, Robert Moldwin
Summary: The study developed and validated the Pelvic Pain Map as a reliable tool for assessing the location of pain in patients with chronic pelvic pain. The map incorporates input from experts and patient feedback to ensure its face validity. The findings suggest that the Pelvic Pain Map has the potential to guide treatment selection and monitor therapeutic response in patients with chronic pelvic pain.
Article
Neurosciences
Yuhui Luo, Abbie Suttle, Qiaojuan Zhang, Peng Wang, Yong Chen
Summary: Orofacial pain, affecting millions of Americans, is influenced by transient receptor potential (TRP) ion channels. The orofacial sensory system differs from the spinal sensory system in pain processing and sensitivities. TRPs in trigeminally-mediated pain have not been extensively documented compared to spinally-mediated pain.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yaron Haviv, Olga Georgiev, Tal Gaver-Bracha, Sharleen Hamad, Alina Nemirovski, Rivka Hadar, Yair Sharav, Doron J. Aframian, Yariv Brotman, Joseph Tam
Summary: This study found that salivary levels of endocannabinoids were lower in patients with chronic orofacial pain (OFP) compared to controls, especially in patients with neurovascular/migraine and neuropathic pain. These findings add a new dimension to our understanding of OFP mechanisms and may have important implications for the diagnosis and treatment of pain.
Article
Biochemistry & Molecular Biology
Glauce Crivelaro Nascimento, Gabrielle Jacob, Bruna Araujo Milan, Gabrielli Leal-Luiz, Bruno Lima Malzone, Airam Nicole Vivanco-Estela, Daniela Escobar-Espinal, Fernando Jose Dias, Elaine Del-Bel
Summary: The pathophysiologic mechanisms of the lateral pterygoid muscles (LPMs) and the trigeminal system related to Parkinson's Disease (PD)-induced orofacial manifestations were investigated. The study found that hemiparkinsonism increased slow skeletal myosin fibers in the LPMs, while in dyskinetic rats, these fibers decreased in the contralateral side of the lesion. Activation of the spinal trigeminal nucleus may be associated with orofacial sensorial impairment in Parkinsonian rats, while a fatigue profile on LPMs is suggested in L-DOPA-induced dyskinesia when the motor and facial nucleus are activated.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Dentistry, Oral Surgery & Medicine
Hong Chen, Chandler Pendleton, Daniel J. Caplan, Xian Jin Xie
Summary: The study found that people with psychological conditions, pain disorders, sleep disorders, or orofacial symptoms are at elevated risks of developing first-onset TMD. Additionally, the coexistence of conditions from multiple body systems increases the risk of developing TMD. Therefore, multisystem risk assessment and interprofessional collaborations are crucial in TMD prevention.
JOURNAL OF THE AMERICAN DENTAL ASSOCIATION
(2021)
Review
Neurosciences
Sufang Liu, Joshua Crawford, Feng Tao
Summary: Orofacial pain, occurring in the head and face, presents a challenge to clinicians due to its high prevalence and limited understanding of underlying mechanisms. Animal models and pain behavioral assessments have advanced our understanding of orofacial pain pathogenesis, despite differences from human symptoms. Choosing appropriate assessment methods can improve research reliability and minimize animal use for evaluating spontaneous pain, evoked pain, and accompanying dysfunction.
Article
Medicine, General & Internal
Bernd Lethaus, Elisabeth Grau, Anita Kloss-Brandstaetter, Luise Brauer, Ruediger Zimmerer, Alexander K. Bartella, Sebastian Hahnel, Anna K. Sander
Summary: This study aimed to assess the therapeutic decisions resulting from an annual multidisciplinary follow-up of cleft patients. The analysis of clinical data from 1126 patients showed a high demand for interdisciplinary assessment, with treatment decisions influenced by experts of different specialties at different time points. It was concluded that specialized centers should concentrate on the therapy and checkup of cleft patients due to the importance of regular follow-up and initiation of treatment protocols.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Health Care Sciences & Services
Swarnalakshmi Raman, Daisuke Ikutame, Kazuo Okura, Yoshizo Matsuka
Summary: Orofacial pain (OFP) is a dental specialty that focuses on diagnosing, managing, and treating disorders affecting the jaw, mouth, face, head, and neck. Effective treatment of OFP requires evidence-based understanding due to the multifactorial nature of these conditions. Treating OFP successfully is crucial as it significantly impacts the quality of life of affected individuals. Precision medicine, which utilizes a patient's genetic profile, shows promise in revolutionizing the management of chronic untreatable pain conditions.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Review
Chemistry, Multidisciplinary
Harry von Piekartz, Alba Paris-Alemany
Summary: The management of patients with chronic orofacial pain is challenging due to the complexity of chronic pain and increased peripheral sensitization in the craniofacial area. Assessing facial somatosensory, cognitive-affective, and motor dysfunctions is crucial for accurate treatment, with tools like two-point discrimination and emotion recognition being altered in patients with orofacial pain. The authors propose treatment options based on brain training techniques and biobehavioral interventions to challenge new directions in rehabilitation and research.
APPLIED SCIENCES-BASEL
(2021)
Review
Cell Biology
Mayank Shrivastava, Liang Ye
Summary: Orofacial neuropathic pain poses challenges for diagnosis and management due to the variability in clinical presentations and limited understanding of its etiology. Research in recent decades has led to the development of diagnostic criteria and assessment tools, along with the recognition of the role of autophagy in neuropathic pain. This review highlights the characteristics and clinical assessment of orofacial neuropathic pain, as well as the potential of autophagy in its modulation and future therapeutic targets.
Review
Clinical Neurology
John E. Dinan, Alexander Smith, James M. Hawkins
CLINICAL NEUROPHARMACOLOGY
(2020)
Article
Dentistry, Oral Surgery & Medicine
Preston S. Duffin, Alexander Smith, James M. Hawkins
JOURNAL OF ENDODONTICS
(2020)
Article
Dentistry, Oral Surgery & Medicine
James Hawkins, Gary Heir, Jeffrey Okeson, Jeffry Shaefer
JOURNAL OF ORAL & FACIAL PAIN AND HEADACHE
(2020)
Article
Clinical Neurology
John E. Dinan, Alexander Smith, James M. Hawkins
Summary: Paroxysmal hemifacial pain (PHFP) is a condition where patients experience episodic attacks of severe unilateral facial pain, which can be effectively treated with therapeutic doses of indomethacin. It is important to consider a diagnosis of PHFP and trial of indomethacin in cases of severe unilateral facial pain not explained by common diagnoses.
Article
Dentistry, Oral Surgery & Medicine
Nickoli Dubyk, Alexander Smith, Preston Criddle, Bradley Jones, James Hawkins
Summary: This article presents a case study of first bite syndrome (FBS) in a 43-year-old man who developed the condition after undergoing partial parotidectomy for mucoepidermoid carcinoma treatment. The patient's orofacial pain was effectively managed by onabotulinumtoxin A injection into the remaining parotid tissue. Onabotulinumtoxin A shows promising results in relieving FBS pain with minimal adverse effects, making it a viable treatment option for oral health care providers treating FBS.
JOURNAL OF THE AMERICAN DENTAL ASSOCIATION
(2022)
Editorial Material
Dentistry, Oral Surgery & Medicine
James Fricton, Hong Chen, Jeffrey R. Shaefer, Jay Mackman, Jeffrey P. Okeson, Richard Ohrbach, Gary D. Klasser, James Hawkins, Robert Hasel, Gary Heir
JOURNAL OF THE AMERICAN DENTAL ASSOCIATION
(2022)
Article
Dentistry, Oral Surgery & Medicine
Group Author Only
JOURNAL OF ORAL & FACIAL PAIN AND HEADACHE
(2021)
Review
Dentistry, Oral Surgery & Medicine
Michael Owen, Benjamin Gray, Nawaz Hack, Leonel Perez, Rhonda J. Allard, James M. Hawkins
Summary: This is the first systematic review that examines the association between BoNTA injection into the masticatory muscles and mandibular bone quality. Although the data were analyzed from a limited number of studies with a small sample size and the quality of the included studies was very low, the majority of available evidence suggests that BoNTA injection results in bony changes. Further research is needed to confirm a dose-dependence effect and the impact of gender and age.
JOURNAL OF ORAL REHABILITATION
(2022)
Review
Pharmacology & Pharmacy
Marcela Romero-Reyes, Sherwin Arman, Antonia Teruel, Satish Kumar, James Hawkins, Simon Akerman
Summary: Orofacial pain is a complex disorder that affects the quality of life of patients and requires multidisciplinary management. Pharmacological treatment involves a wide range of medications, while injections can be used as adjunct therapy. Research for new therapeutic targets is important to improve care for patients with orofacial pain disorders.