Review
Biochemistry & Molecular Biology
Remo Poto, Gjada Criscuolo, Gianni Marone, Chris E. Brightling, Gilda Varricchi
Summary: Mast cells in the lung of asthmatic patients play a significant role in airway inflammation and remodeling. They activate various immune cells and modulate the activity of structural cells in the lung. Therapies targeting mast cell mediators and receptors have shown effectiveness in treating different types of asthma. Depleting mast cells has also shown promising results. These findings highlight the importance of mast cell-targeted treatments in asthma.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Chang Youp Ok, Sera Park, Hye-Ock Jang, Takashi Takata, Ok-Hee Lee, Moon-Kyoung Bae, Soo-Kyung Bae
Summary: The study demonstrated that FK866 could inhibit hydrogen peroxide-induced premature senescence of human dental pulp cells by reducing senescence markers and oxidative stress induction, showing potential therapeutic effects in alleviating inflammation and cellular aging in dental pulp.
Article
Biochemistry & Molecular Biology
Michaela Nicole Hoehne, Lianne J. H. C. Jacobs, Kim Jasmin Lapacz, Gaetano Calabrese, Lena Maria Murschall, Teresa Marker, Harshita Kaul, Aleksandra Trifunovic, Bruce Morgan, Mark Fricker, Vsevolod V. Belousov, Jan Riemer
Summary: Hydrogen peroxide (H2O2) plays a key role in signaling at physiological levels, but can cause molecular damage at high concentrations. This study used a genetically encoded H2O2 sensor to investigate how mitochondria release H2O2 in intact cells. The researchers found that H2O2 is released by mitochondria directly at the surface of the organelle and in the bulk cytosol, and that gradient formation is controlled by cytosolic peroxiredoxins.
Article
Multidisciplinary Sciences
Hai-Jian Sun, Zhi-Yuan Wu, Xiao-Wei Nie, Xin-Yu Wang, Jin-Song Bian
Summary: Hydrogen sulfide (H2S) plays multiple physiological functions in mammal systems, with a significant role in regulating liver functions. Targeting H2S-producing enzymes may offer a promising strategy for managing hepatic disorders.
JOURNAL OF ADVANCED RESEARCH
(2021)
Article
Medicine, Research & Experimental
Yoshikazu Kuwahara, Kazuo Tomita, Mehryar Habibi Roudkenar, Amaneh Mohammadi Roushandeh, Yusuke Urushihara, Kento Igarashi, Akihiro Kurimasa, Tomoaki Sato
Summary: The study revealed that modulation of mitochondrial function is implicated in the radioresistance phenotype of cancer cells, and radioresistance of clinically relevant radioresistant cells is reversible. Further studies are needed to clarify the mechanisms underlying cancer cell radioresistance.
Review
Chemistry, Multidisciplinary
Alexios G. Stamoulis, David L. Bruns, Shannon S. Stahl
Summary: This Perspective analyzes the thermodynamic principles underlying catalytic aerobic oxidation reactions and borrows concepts from the study of the oxygen reduction reaction (ORR) in fuel cells. The central role of catalyst overpotential in guiding the development of aerobic oxidation reactions is highlighted. Applications and implications of these concepts are discussed through case studies.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Cell Biology
Qixuan Li, Tianyi Wang, Youlang Zhou, Jiahai Shi
Summary: Cuproptosis, a form of cell death induced by disruption of copper binding, has potential in treating tumor diseases. This study provides an introduction to copper metabolism and aims to summarize the relationships between cuproptosis and therapeutic targets and signaling pathways of lung cancer, with the goal of translating experimental results into clinical treatment.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Article
Plant Sciences
Li Xiang, Yue Gao, Shiyu Chen, Jiayi Sun, Jiasi Wu, Xianli Meng
Summary: This review summarizes the pharmacological effects and molecular mechanisms of Scutellaria baicalensis in lung cancer therapy. Scutellaria baicalensis and its constituents exhibit multiple anti-cancer mechanisms against lung cancer and show high antitumor efficacy and safety in animal models.
Review
Oncology
Lei Wang, Zeng Jin, Rohan P. Master, Chandra K. Maharjan, Madison E. Carelock, Tiffany B. A. Reccoppa, Myung-Chul Kim, Ryan Kolb, Weizhou Zhang
Summary: This article summarizes the important features of breast cancer stem cells, major signaling pathways, and cellular interactions within the tumor microenvironment, highlighting the significance of BCSCs in breast cancer and potential therapeutic strategies.
Article
Electrochemistry
Tao Wu, Xin Ning, Qiang Xiong, Fan Zhang, Pingang He
Summary: A novel detection strategy using scanning electrochemical microscopy (SECM) has been developed to monitor the release of reactive oxygen species (ROS) at the single-cell level without interference from dissolved oxygen (DO). The study provides insights into the effect of pH on ROS release by cancer cells.
ELECTROCHIMICA ACTA
(2022)
Review
Cell Biology
Milad Moloudizargari, Ali Govahi, Marjan Fallah, Mohammad A. Rezvanfar, Mohammad H. Asghari, Mohammad Abdollahi
Summary: Understanding the interaction between MSCs and NK cells is crucial for developing therapeutic approaches, though the current knowledge in this area is still in its early stages and further well-defined studies are warranted.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Zehuan Liao, Han Lin Yeo, Siaw Wen Wong, Yan Zhao
Summary: Cellular senescence is a complex process affecting various biological processes, with characteristics including senescence-associated phenotype and cell cycle arrest. Persistent senescence is associated with aging pathologies, while transient senescence is linked to beneficial programs.
Review
Medicine, Research & Experimental
Xue Han, Bo Li, Shitai Zhang
Summary: This article summarizes the molecular mechanisms of MIR503HG in disease and its potential applications in diagnosis, prognosis, and treatment. It also raises some unanswered questions in this area, providing insights for future research.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Biochemistry & Molecular Biology
Elizabeth Corteselli, Reem Aboushousha, Yvonne Janssen-Heininger
Summary: Glutathione plays a crucial role as an antioxidant and regulates biological processes through protein S-glutathionylation. Recent studies have implicated protein S-glutathionylation in the pathogenesis of various diseases, including idiopathic pulmonary fibrosis, and its association with oxidative stress and epithelial cell apoptosis.
Article
Chemistry, Analytical
Jiaxin Hong, Xiaogang Guan, Yao Chen, Xiaodong Tan, Shiya Zhang, Guoqiang Feng
Summary: Mitophagy is a crucial cellular process that plays vital roles in regulating cellular metabolism and mitochondrial quality control. Mitochondrial viscosity, closely associated with mitochondrial status, is a key microenvironmental index. To monitor mitophagy and mitochondrial viscosity changes, a probe called Mito-3 was developed. Mito-3, along with other probes, showed sensitivity to viscosity changes and fluorescence enhancement. These probes were successfully used to locate and visualize mitochondria, as well as monitor mitochondrial viscosity changes in cells. Additionally, Mito-3 was applied to visualize the mitophagy process induced by starvation and revealed an increase in mitochondrial viscosity during mitophagy.
ANALYTICAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Brajesh Kumar, Kumari Smita, Rachid Seqqat, Karen Benalcazar, Marcelo Grijalva, Luis Cumbal
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
(2016)
Article
Materials Science, Biomaterials
Brajesh Kumar, Kumari Smita, Luis Cumbal, Javier Camacho, Elisabeth Hernandez-Gallegos, Maria de Guadalupe Chavez-Lopez, Marcelo Grijalva, Kleber Andrade
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2016)
Review
Materials Science, Biomaterials
Suhas Ramesh, Marcelo Grijalva, Alexis Debut, Beatriz G. de la Torre, Fernando Albericio, Luis H. Cumbal
BIOMATERIALS SCIENCE
(2016)
Review
Cell Biology
Maria Jose Vallejo, Lizeth Salazar, Marcelo Grijalva
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2017)
Article
Immunology
Juan M. Galarza, Rodrigo Barquera, Ana M. Tito Alvarez, Diana I. Hernandez Zaragoza, Gabriela Peralta Sevilla, Andrea Tamayo, Mariel Perez, David Davila, Lotty Birnberg, Victor Acuna Alonzo, Johannes Krause, Marcelo Grijalva
Article
Chemistry, Applied
Katherine Guzman, Brajesh Kumar, Maria Jose Vallejo, Marcelo Grijalva, Alexis Debut, Luis Cumbal
PROGRESS IN ORGANIC COATINGS
(2019)
Article
Microbiology
Marcelo Grijalva, Katherine De La Torre, Nataly Sanchez
NEW MICROBIOLOGICA
(2020)
Article
Pharmacology & Pharmacy
Marcelo Grijalva, Nayara Gomez, Lizeth Salazar, Maria Jose Vallejo, Maria Elena Cazar, Adriana Jara Bermeo, Luis Castillo
INTERNATIONAL JOURNAL OF PHARMACEUTICAL AND PHYTOPHARMACOLOGICAL RESEARCH
(2019)
Article
Nanoscience & Nanotechnology
Lizeth Salazar, Maria Jose Vallejo Lopez, Marcelo Grijalva, Luis Castillo, Alexander Maldonado
JOURNAL OF NANOTECHNOLOGY
(2018)
Article
Tropical Medicine
Patricia Jimenez, Karina Calvopina, Diana Herrera, Carlos Rojas, Laura Perez-Lago, Marcelo Grijalva, Remedios Guna, Dario Garcia-de Viedma
Article
Infectious Diseases
M Dendis, R Horváth, J Michálek, F Ruzicka, M Grijalva, M Bartos, J Benedík
CLINICAL MICROBIOLOGY AND INFECTION
(2003)
Article
Cardiac & Cardiovascular Systems
M Grijalva, R Horváth, M Dendis, J Cerny, J Benedik
Article
Chemistry, Multidisciplinary
S. Bhakya, S. Muthukrishnan, M. Sukumaran, M. Grijalva, L. Cumbal, J. H. Franklin Benjamin, T. Senthil Kumar, M. V. Rao