PTEN Activation by DNA Damage Induces Protective Autophagy in Response to Cucurbitacin B in Hepatocellular Carcinoma Cells

Cucurbitacin E induces caspase-dependent apoptosis and protective autophagy mediated by ROS in lung cancer cells

(2016) Guixin Ma et al.   CHEMICO-BIOLOGICAL INTERACTIONS

2-Methoxy-6-acetyl-7-methyljuglone (MAM), a natural naphthoquinone, induces NO-dependent apoptosis and necroptosis by H 2 O 2 -dependent JNK activation in cancer cells

(2016) Wen Sun et al.   FREE RADICAL BIOLOGY AND MEDICINE

Autophagy is associated with cucurbitacin D-induced apoptosis in human T cell leukemia cells

(2016) Tsukasa Nakanishi et al.   MEDICAL ONCOLOGY

Regulated necrosis: disease relevance and therapeutic opportunities

(2016) Marcus Conrad et al.   NATURE REVIEWS DRUG DISCOVERY

Erianin induces G2/M-phase arrest, apoptosis and autophagy via the ROS/JNK signaling pathway in human osteosarcoma cells in vitro and in vivo

(2016) H Wang et al.   Cell Death & Disease

Total Tanshinones-Induced Apoptosis and Autophagy Via Reactive Oxygen Species in Lung Cancer 95D Cells

(2015) Hongwei Gao et al.   AMERICAN JOURNAL OF CHINESE MEDICINE

Autophagy-associated Targeting Pathways of Natural Products during Cancer Treatment

(2015) Shu-Fang Zhang et al.   Asian Pacific Journal of Cancer Prevention

ATM-mediated PTEN phosphorylation promotes PTEN nuclear translocation and autophagy in response to DNA-damaging agents in cancer cells

(2015) Jing-Hong Chen et al.   Autophagy

The interplay between DNA repair and autophagy in cancer therapy

(2015) Dan Zhang et al.   CANCER BIOLOGY & THERAPY

Cucurbitacin B induces DNA damage and autophagy mediated by reactive oxygen species (ROS) in MCF-7 breast cancer cells

(2015) Guowen Ren et al.   Journal of Natural Medicines

Cell Death Signaling

(2015) Douglas R. Green et al.   Cold Spring Harbor Perspectives in Biology

Cucurbitacin E Induces Autophagy via Downregulating mTORC1 Signaling and Upregulating AMPK Activity

(2015) Qing-Bing Zha et al.   PLoS One

Regulated Cell Death: Signaling and Mechanisms

(2014) Avi Ashkenazi et al.   Annual Review of Cell and Developmental Biology

Cucurbitacin B Induces DNA Damage, G2/M Phase Arrest, and Apoptosis Mediated by Reactive Oxygen Species (ROS) in Leukemia K562 Cells

(2014) Jiajie Guo et al.   Anti-Cancer Agents in Medicinal Chemistry

Caspases: A Molecular Switch Node in the Crosstalk between Autophagy and Apoptosis

(2014) Haijian Wu et al.   International Journal of Biological Sciences

Cucurbitacin I Induces Protective Autophagy in Glioblastomain Vitroandin Vivo

(2014) Guang Yuan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cucurbitacin B inhibits proliferation and induces apoptosis via STAT3 pathway inhibition in A549 lung cancer cells

(2014) MENG ZHANG et al.   Molecular Medicine Reports

Cucurbitacin B inhibits growth and induces apoptosis through the JAK2/STAT3 and MAPK pathways in SH-SY5Y human neuroblastoma cells

(2014) QIAN ZHENG et al.   Molecular Medicine Reports

Regulated necrosis: the expanding network of non-apoptotic cell death pathways

(2014) Tom Vanden Berghe et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cucurbitacin E Has Neuroprotective Properties and Autophagic Modulating Activities on Dopaminergic Neurons

(2014) Anne-Marie Arel-Dubeau et al.   Oxidative Medicine and Cellular Longevity

Cucurbitacin B Induced ATM-Mediated DNA Damage Causes G2/M Cell Cycle Arrest in a ROS-Dependent Manner

(2014) Jiajie Guo et al.   PLoS One

Natural Products Targeting Autophagy via the PI3K/Akt/mTOR Pathway as Anticancer Agents

(2013) Hui Sun et al.   Anti-Cancer Agents in Medicinal Chemistry

The role of cell signalling in the crosstalk between autophagy and apoptosis

(2013) Laurence A. Booth et al.   CELLULAR SIGNALLING

Defective chromatin recruitment and retention of NHEJ core components in human tumor cells expressing a Cyclin E fragment

(2013) Payel Chatterjee et al.   NUCLEIC ACIDS RESEARCH

Graveoline Isolated from Ethanolic Extract ofRuta graveolensTriggers Apoptosis and Autophagy in Skin Melanoma Cells: A Novel Apoptosis-Independent Autophagic Signaling Pathway

(2013) Samrat Ghosh et al.   PHYTOTHERAPY RESEARCH

Cucurbitacin induces autophagy through mitochondrial ROS production which counteracts to limit caspase-dependent apoptosis

(2012) Tiejun Zhang et al.   Autophagy

Hydroxyl Radical (^|^middot;OH) Played a Pivotal Role in Oridonin-Induced Apoptosis and Autophagy in Human Epidermoid Carcinoma A431 Cells

(2012) Yang Yu et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

PTEN in DNA damage repair

(2012) Mei Ming et al.   CANCER LETTERS

The functions and regulation of the PTEN tumour suppressor

(2012) Min Sup Song et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

N-acetylcysteine (NAC) inhibits cell growth by mediating the EGFR/Akt/HMG box-containing protein 1 (HBP1) signaling pathway in invasive oral cancer

(2012) Ming-Fen Lee et al.   ORAL ONCOLOGY

Cucurbitacin B Induces Cell Cycle Arrest, Apoptosis and Autophagy Associated with G Actin Reduction and Persistent Activation of Cofilin in Jurkat Cells

(2012) Jun-Shan Zhu et al.   PHARMACOLOGY

The crosstalk between autophagy and apoptosis: where does this lead?

(2012) Claire Gordy et al.   Protein & Cell

Histone deacetylase inhibitor valproic acid sensitizes B16F10 melanoma cells to cucurbitacin B treatment

(2011) Dongyun Ouyang et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

The Beclin 1 network regulates autophagy and apoptosis

(2011) R Kang et al.   CELL DEATH AND DIFFERENTIATION

Autophagy as a target for anticancer therapy

(2011) Filip Janku et al.   Nature Reviews Clinical Oncology

Anti-tumor potential of ethanol extract of Curcuma phaeocaulis Valeton against breast cancer cells

(2011) Xiuping Chen et al.   PHYTOMEDICINE

Cucurbitacin B induces apoptosis and S phase cell cycle arrest in BEL-7402 human hepatocellular carcinoma cells and is effective via oral administration

(2010) Kin Tak Chan et al.   CANCER LETTERS

Bcl-2 and Bcl-xL play important roles in the crosstalk between autophagy and apoptosis

(2010) Feifan Zhou et al.   FEBS Journal

Mitochondria and cell death: outer membrane permeabilization and beyond

(2010) Stephen W. G. Tait et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cucurbitacin B Induces Apoptosis by Inhibition of the JAK/STAT Pathway and Potentiates Antiproliferative Effects of Gemcitabine on Pancreatic Cancer Cells

(2009) N. H. Thoennissen et al.   CANCER RESEARCH

ULK1·ATG13·FIP200 Complex Mediates mTOR Signaling and Is Essential for Autophagy

(2009) Ian G. Ganley et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cucurbitacin B induces G2arrest and apoptosisviaa reactive oxygen species-dependent mechanism in human colon adenocarcinoma SW480 cells

(2009) Shusuke Yasuda et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Reactive oxygen species and nitric oxide regulate mitochondria-dependent apoptosis and autophagy in evodiamine-treated human cervix carcinoma HeLa cells

(2008) Jia Yang et al.   FREE RADICAL RESEARCH