Article
Endocrinology & Metabolism
H. Johansson, G. Naureen, R. Iqbal, L. Jafri, A. H. Khan, M. Umer, E. Liu, L. Vandenput, M. Lorentzon, E. V. McCloskey, J. A. Kanis, N. C. Harvey
Summary: By comparing the utility of intervention thresholds at a T-score <= - 2.5 or based on a FRAX probability, it was found that the FRAX-based threshold was more effective in identifying women at high fracture risk, while the T-score threshold showed lower sensitivity, and the associated fracture risk decreased significantly with age.
OSTEOPOROSIS INTERNATIONAL
(2022)
Article
Endocrinology & Metabolism
Dueanchonnee Sribenjalak, Suranut Charoensri, Chatlert Pongchaiyakul
Summary: This study aimed to determine the FRAX intervention threshold in postmenopausal Thai women based on a history of hip fracture. The optimal FRAX thresholds for hip fracture were found to be slightly different from the standard recommendation.
ARCHIVES OF OSTEOPOROSIS
(2022)
Article
Endocrinology & Metabolism
Nasser M. Al-Daghri, Shaun Sabico, Yousef Al-Saleh, Riad Sulimani, Naji J. Aljohani, Eman Sheshah, Abdulaziz Alodhayani, Nicholas C. Harvey, Enwu Liu, Mattias Lorentzon, Eugene McCloskey, Liesbeth Vandenput, Helena Johansson, John A. Kanis
Summary: An assessment and treatment pathway based on age-specific intervention thresholds in Saudi Arabia was developed to identify high-risk fracture patients and avoid unnecessary treatment in low-risk patients. The study used FRAX-derived fracture probabilities and epidemiological data specific to Saudi Arabia to guide treatment decisions.
ARCHIVES OF OSTEOPOROSIS
(2021)
Article
Endocrinology & Metabolism
Olga Lesnyak, Alla Zakroyeva, Varta Babalyan, Victor Cazac, Gulzhan Gabdulina, Said Ismailov, Olga Lobanchenko, Ema Rudenka, Marina Tsagareli, Helena Johansson, Nickolas C. Harvey, Eugene McCloskey, John A. Kanis
Summary: This study aimed to derive and compare FRAX-based intervention and BMD assessment thresholds for 8 Eurasian countries in the EVA study. The age-specific intervention thresholds varied significantly among countries at younger ages but became less distinct with advancing age. The newly established FRAX-based intervention thresholds provide an opportunity to improve the clinical detection of individuals at high fracture risk and enhance treatment rates in the 8 Eurasian countries.
ARCHIVES OF OSTEOPOROSIS
(2021)
Article
Endocrinology & Metabolism
Lakshmi Nagendra, Nisha Bhavani, V. Usha Menon, Praveen V. Pavithran, Arun S. Menon, Nithya Abraham, Vasantha Nair, Harish Kumar
Summary: The study derived and validated population-specific intervention thresholds for treatment of osteoporosis in India using the FRAX (R) model, even without bone mineral density measurement. The thresholds were found to be valid in 98.7% of patients in the validation cohort, demonstrating the efficacy of using these thresholds to avoid overtreatment.
ARCHIVES OF OSTEOPOROSIS
(2021)
Article
Endocrinology & Metabolism
M. Chandran, G. Ganesan, K. B. Tan, J-Y Reginster, M. Hiligsmann
Summary: Cost-effectiveness analysis of FRAX(R) intervention thresholds in Singaporean women over 50 years of age showed that generic alendronate was cost-effective at age-dependent major osteoporotic fracture ITs from the age of 65. Identifying women at any age above 50 with a 10-year risk of MOF or HF of 14% or 3.5% would lead to efficient use of resources in osteoporosis management. This could contribute to reducing the burden of osteoporotic fractures in Singapore.
OSTEOPOROSIS INTERNATIONAL
(2021)
Article
Endocrinology & Metabolism
Sarath Lekamwasam, Thilina Abeygunasekara, Nirmala Rathnayake, Gayani Liyanage, Sewwandi Subasinghe
Summary: Age-dependent assessment thresholds assist in categorizing women aged 40 years or more according to their fracture risk based on bone mineral density information.
ARCHIVES OF OSTEOPOROSIS
(2022)
Article
Pediatrics
Gary A. Smith, Sandhya Kistamgari, Mark Splaingard
Summary: This study evaluates the age-dependent responsiveness of children aged 5 to 12 to different types of smoke alarms. It found that child age significantly influences the proportion of children who awaken and escape in response to different alarm types. The effectiveness of the alarms increases with child age.
Article
Endocrinology & Metabolism
Lan Yang, Mary Dempsey, Attracta Brennan, Bryan Whelan, E. Erjiang, Tingyan Wang, Rebecca Egan, Kelly Gorham, Fiona Heaney, Catherine Armstrong, Guadalupe Morote Ibarrola, Amina Gsel, Ming J. Yu, John Carey
Summary: The appropriate use of FRAX can reduce the need for DXA scans and identify individuals at the highest risk. Comparing FRAX results with and without inclusion of BMD suggests that clinicians should carefully consider the importance of including BMD in fracture risk estimation for individual patients.
ARCHIVES OF OSTEOPOROSIS
(2023)
Article
Endocrinology & Metabolism
Lopez Gavilanez E, Valdivieso Jara J, Imaicela Naula L, Cedeno German R
Summary: This study assesses the clinical impact of FRAX-based intervention thresholds in Ecuadorian women and proposes a combination of fixed and age-specific thresholds to optimize the selection of women eligible for intervention. The results show that in low to moderate fracture risk countries, using a fixed threshold starting at age 75 maximizes the proportion of women eligible for treatment.
REVISTA DE OSTEOPOROSIS Y METABOLISMO MINERAL
(2022)
Article
Multidisciplinary Sciences
Enqi Liu, Xinzheng Hou, Siqi Liu, Jing Han, Hao Lv
Summary: The study aimed to determine the association between hemoglobin and bone mineral density in the lumbar and thoracic spine of adults. The analysis of the non-institutionalized US population found a negative correlation between hemoglobin and lumbar spine BMD. However, this correlation varied among different genders and races. Further research is needed to understand the underlying mechanisms.
SCIENTIFIC REPORTS
(2022)
Article
Endocrinology & Metabolism
Gregory A. Kline, Suzanne N. Morin, Lisa M. Lix, Eugene McCloskey, Helena Johansson, Nicholas C. Harvey, John A. Kanis, William D. Leslie
Summary: This study found that medical comorbidity is associated with fracture risk and can increase the risk of fractures independently of FRAX. By using complex and simple measures of medical comorbidity, FRAX-based risk estimates can be modified to capture the increased fracture risk associated with multiple comorbid conditions in older patients.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Hans P. Dimai, Helena Johansson, Nicholas C. Harvey, Mattias Lorentzon, Enwu Liu, Liesbeth Vandenput, Astrid Fahrleitner-Pammer, Peter Pietschmann, Christian Muschitz, Eugene McCloskey, John A. Kanis
Summary: This study provides a reference document for the further development of osteoporosis management guidelines in Austria, using the FRAX-based intervention thresholds for high and very high fracture risk. The adoption of the management pathway proposed by NOGG in the UK applied using the Austrian FRAX tool categorizes a significant percentage of Austrian women aged 40 years or more eligible for treatment, with a substantial number classified as very high risk.
ARCHIVES OF OSTEOPOROSIS
(2022)
Article
Pharmacology & Pharmacy
Shan-Fu Yu, Ming-Han Chen, Jia-Feng Chen, Yu-Wei Wang, Ying-Chou Chen, Chung-Yuan Hsu, Han-Ming Lai, Wen-Chan Chiu, Chi-Hua Ko, Hsiao-Ru He, Tien-Tsai Cheng
Summary: This study establishes a FRAX(R)-based prediction model for predicting rheumatoid arthritis-associated fragility fractures. The results show that the fixed intervention threshold (FITD) and fixed intervention threshold (Taiwan) (FITT) have better discriminative power in predicting fractures compared to other models.
THERAPEUTIC ADVANCES IN CHRONIC DISEASE
(2022)
Article
Endocrinology & Metabolism
Enrique Lopez Gavilanez, Imaicela N. N. Luis, Navarro G. G. Mario, Helena Johansson, Nicholas C. C. Harvey, Mattias Lorentzon, Enwu Liu, Liesbeth Vandenput, Eugene V. V. McCloskey, John A. A. Kanis
Summary: Assessment and treatment pathways based on FRAX-based intervention thresholds in Chile can effectively identify high fracture risk patients and avoid unnecessary treatment for those at low fracture risk. The application of hybrid intervention thresholds helps to address the disparity in fracture probabilities observed with age-dependent thresholds.
ARCHIVES OF OSTEOPOROSIS
(2022)
Article
Endocrinology & Metabolism
Carrie Ye, Suzanne N. Morin, Lisa M. Lix, Eugene V. McCloskey, Helena Johansson, Nicholas C. Harvey, John A. Kanis, William D. Leslie
Summary: The study assessed the performance of the Fracture Risk Assessment Tool (FRAX) in predicting incident fractures in men with prostate cancer. The results showed that FRAX reliably predicts fractures in this population.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Article
Endocrinology & Metabolism
Anne R. Cappola, Richard J. Auchus, Ghada El-Hajj Fuleihan, David J. Handelsman, Rita R. Kalyani, Michael McClung, Cynthia A. Stuenkel, Michael O. Thorner, Joseph G. Verbalis
Summary: Multiple changes occur in various endocrine systems as individuals age. The understanding of age-related changes and their clinical management is developing. This statement reviews the current research in different endocrine axes and conditions specific to older individuals, including available therapies, clinical trials, key points, and scientific gaps. The goal is to inform future research to improve prevention and treatment strategies for age-associated endocrine conditions in older individuals.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Didier Hans, Michele McDermott, Shuang Huang, Min Kim, Enisa Shevroja, Michael McClung
Summary: Up to 10 years of denosumab treatment significantly improved bone microarchitecture in postmenopausal women with osteoporosis, independently of bone mineral density. The treatment also decreased the number of high fracture-risk patients and shifted more patients to lower fracture-risk categories.
OSTEOPOROSIS INTERNATIONAL
(2023)
Review
Medicine, General & Internal
Marlene Chakhtoura, Rachelle Haber, Malak Ghezzawi, Caline Rhayem, Raya Tcheroyan, Christos S. Mantzoros
Summary: Obesity is a widespread health issue and medical weight management has seen significant advancements in recent years, leading to improved treatment options. Various medications have been approved for the management of obesity and there are promising novel drugs being researched.
Article
Endocrinology & Metabolism
Michael R. McClung, Donald Betah, Cynthia Deignan, Yifei Shi, Jen Timoshanko, Felicia Cosman
Summary: Romosozumab significantly reduced fracture risk and increased bone mineral density in women at high fracture risk.
ENDOCRINE PRACTICE
(2023)
Article
Endocrinology & Metabolism
William D. Leslie, Neil Binkley, John T. Schousboe, Eugene V. Mccloskey, Helena Johansson, Nicholas C. Harvey, John A. Kanis
Summary: This study found that abdominal thickness has an impact on FRAX-derived major osteoporotic fracture and hip fracture compared to BMI. The effect is stronger before the age of 65 and there is also an increased risk of lower abdominal thickness for individuals with diabetes. These findings suggest the need to investigate abdominal thickness beyond BMI and sex prediction as an independent risk factor for fracture using FRAX.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Article
Endocrinology & Metabolism
William D. Leslie
Summary: This study investigated differences in FRAX scores among different racial/ethnic groups and explored the impact of using a population-based calculator on treatment qualification for osteoporosis. The study found disparities in treatment qualification using existing US race/ethnic-specific FRAX calculators, while using a population-based calculator could reduce these disparities.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Article
Endocrinology & Metabolism
Gregory A. A. Kline, Suzanne N. N. Morin, Lisa M. M. Lix, William D. D. Leslie
Summary: Based on the FLEX study in 2006, a 5-year course of bisphosphonate therapy was found to be sufficient for most women. However, despite the increased risk of atypical femoral fractures associated with long-term use, up to one-third of patients continued to receive bisphosphonate therapy for over 10 years after 2010.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Review
Endocrinology & Metabolism
E. Michael Lewiecki, Teresita Bellido, John P. Bilezikian, Jacques P. Brown, Azeez Farooki, Christopher S. Kovacs, Brendan Lee, William D. Leslie, Michael R. McClung, Mark L. Prasarn, Deborah E. Sellmeyer
Summary: The 23rd annual Santa Fe Bone Symposium brought together attendees from various states and countries to discuss topics related to osteoporosis and other bone diseases. The event included plenary presentations, panel discussions, workshops, and oral presentations of research abstracts.
JOURNAL OF CLINICAL DENSITOMETRY
(2023)
Article
Endocrinology & Metabolism
William D. Leslie, Neil Binkley, Heenam Goel, Didier Hans, Eugene V. McCloskey
Summary: The exclusion of vertebral levels affects the trabecular bone score (TBS) and FRAX-based treatment recommendations. Adjusting for level-specific differences in TBS reduces the reclassification in FRAX-based treatment recommendations.
JOURNAL OF CLINICAL DENSITOMETRY
(2023)
Article
Endocrinology & Metabolism
William D. Leslie, Neil Binkley, Didier Hans
Summary: Trabecular bone score (TBS) is an independent risk factor for fracture that is not dependent on bone mineral density (BMD). This study found that TBS is still useful in the presence of extreme structural artifact that affects lumbar spine BMD measurements, but it is significantly affected by the presence of multilevel degenerative changes and/or instrumentation.
JOURNAL OF CLINICAL DENSITOMETRY
(2023)
Article
Endocrinology & Metabolism
William D. Leslie, Neil Binkley, Heenam Goel, Eugene V. McCloskey, Didier Hans
Summary: The use of FRAX adjusted for lumbar vertebral levels and specifically using only L1 for TBS measurement improves the accuracy of fracture prediction.
JOURNAL OF CLINICAL DENSITOMETRY
(2023)
Correction
Endocrinology & Metabolism
Andrea Giustina, Luigi di Filippo, Antonio Facciorusso, Robert A. Adler, Neil Binkley, Jens Bollerslev, Roger Bouillon, Felipe F. Casanueva, Giulia Martina Cavestro, Marlene Chakhtoura, Caterina Conte, Lorenzo M. Donini, Peter R. Ebeling, Angelo Fassio, Stefano Frara, Claudia Gagnon, Giovanni Latella, Claudio Marcocci, Jeffrey I. Mechanick, Salvatore Minisola, Rene Rizzoli, Ferruccio Santini, Joseph L. Shaker, Christopher Sempos, Fabio Massimo Ulivieri, Jyrki K. Virtanen, Nicola Napoli, Anne L. Schafer, John P. Bilezikian
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
(2023)
Review
Endocrinology & Metabolism
Andrea Giustina, Luigi di Filippo, Antonio Facciorusso, Robert A. Adler, Neil Binkley, Jens Bollerslev, Roger Bouillon, Felipe F. Casanueva, Giulia Martina Cavestro, Marlene Chakhtoura, Caterina Conte, Lorenzo M. Donini, Peter R. Ebeling, Angelo Fassio, Stefano Frara, Claudia Gagnon, Giovanni Latella, Claudio Marcocci, Jeffrey I. Mechanick, Salvatore Minisola, Rene Rizzoli, Ferruccio Santini, Joseph L. Shaker, Christopher Sempos, Fabio Massimo Ulivieri, Jyrki K. Virtanen, Nicola Napoli, Anne L. Schafer, John P. Bilezikian
Summary: Bariatric surgery is associated with a decrease in 25(OH) vitamin D levels and increased risk of skeletal complications. Guidelines for assessing and supplementing vitamin D in bariatric patients before and after surgery are lacking. This systematic review and meta-analysis provide recommendations for vitamin D management in bariatric patients based on published experience. Vitamin D levels should be assessed pre- and postoperatively in all bariatric surgery patients, and high-dose supplementation is recommended after surgery.
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
(2023)
Article
Nutrition & Dietetics
Nagham Nafiz Hendi, Marlene Chakhtoura, Yasser Al-Sarraj, Dania Saleh Basha, Omar Albagha, Ghada El-Hajj Fuleihan, Georges Nemer
Summary: The Middle East region has a high prevalence of vitamin D deficiency, particularly among elderly individuals. Genetic studies on vitamin D have focused mostly on European populations, therefore there is a lack of research on the genetic factors affecting elderly people in the Middle East. In this study, we identified novel genomic loci associated with vitamin D levels in elderly Lebanese individuals and confirmed the replication of numerous variants from a European study. Our findings provide new insights into the genetic mechanisms of vitamin D deficiency in elderly Middle Eastern populations and can aid in the development of personalized approaches for its management.