Article
Endocrinology & Metabolism
Chor-Wing Sing, Tzu-Chieh Lin, Sharon Bartholomew, J. Simon Bell, Corina Bennett, Kebede Beyene, Pauline Bosco-Levy, Brian D. Bradbury, Amy Hai Yan Chan, Manju Chandran, Cyrus Cooper, Maria de Ridder, Caroline Y. Doyon, Cecile Droz-Perroteau, Ganga Ganesan, Sirpa Hartikainen, Jenni Ilomaki, Han Eol Jeong, Douglas P. Kiel, Kiyoshi Kubota, Edward Chia-Cheng Lai, Jeff L. Lange, E. Michael Lewiecki, Julian Lin, Jiannong Liu, Joe Maskell, Mirhelen Mendes de Abreu, James O'Kelly, Nobuhiro Ooba, Alma B. Pedersen, Albert Prats-Uribe, Daniel Prieto-Alhambra, Simon Xiwen Qin, Ju-Young Shin, Henrik T. Sorensen, Kelvin Bryan Tan, Tracy Thomas, Anna-Maija Tolppanen, Katia M. C. Verhamme, Grace Hsin-Min Wang, Sawaeng Watcharathanakij, Stephen J. Wood, Ching-Lung Cheung, Ian C. K. Wong
Summary: In this international study, the researchers analyzed the incidence of hip fractures, post-fracture treatment, and all-cause mortality following hip fractures across different countries and regions. They used patient-level healthcare data from 19 countries and identified 4,115,046 hip fractures from 2005 to 2018. The study revealed variations in the global epidemiology of hip fractures and post-fracture outcomes, highlighting the need for interventions to reduce the burden of osteoporotic fractures.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Article
Geriatrics & Gerontology
Warrington W. Q. Hsu, Xiaowen Zhang, Chor-Wing Sing, Gloria H. Y. Li, Kathryn C. B. Tan, Annie W. C. Kung, Janus S. H. Wong, Ian Chi-Kei Wong, Ching-Lung Cheung
Summary: The study found that hip fracture was associated with an increased risk of dementia among older adults, especially in women. Further research on the potential role of hip fracture in the development of dementia could benefit the management of both conditions in older adults.
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2022)
Article
Geriatrics & Gerontology
Isabel Geiger, Christian Kammerlander, Christine Hoefer, Ruth Volland, Joerg Trinemeier, Martina Henschelchen, Thomas Friess, Wolfgang Boecker, Leonie Sundmacher
Summary: The study aims to evaluate whether a coordinated care programme can reduce the secondary fracture rate for patients with fragility hip fractures in Germany, by implementing systematic diagnostics, falls prevention programmes, and guideline-adherent interventions based on the Fracture Liaison Services model. The findings will shed light on potential barriers to FLS implementation in the German healthcare system.
Article
Endocrinology & Metabolism
Zaineb Mohsin, M. Kassim Javaid, Antony Johansen
Summary: Hip fractures are strong risk factors for further fractures. However, there is significant variability in the prescription of anti-osteoporosis medication, particularly injectables, among different hospitals in England and Wales. Further investigation is needed to understand and address this variability.
ARCHIVES OF OSTEOPOROSIS
(2023)
Article
Endocrinology & Metabolism
Thomas J. Hjelholt, Soren P. Johnsen, Peter K. Brynningsen, Grethe Andersen, Alma B. Pedersen
Summary: Considerable uncertainty exists regarding the risk factors for recurrent fracture among older patients with hip fracture. This study aimed to investigate the relationship between prefracture stroke history, baseline mobility, and the risk of recurrent hip fracture. The findings showed that stroke history was associated with the cumulative incidence of recurrent hip fracture within one year, but its association varied depending on the baseline mobility of the patients.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Article
Endocrinology & Metabolism
Rafaela Martinez Copes, Fabio Vasconcellos Comim, Nayara Silveira Barrios, Melissa Orlandin Premaor
Summary: The study estimated the incidences of total fracture, major fracture, and hip fractures in postmenopausal women in primary care in Southern Brazil, with rates of 22.3, 15.0, and 3.3 per 1000 person/year respectively. The FRAX algorithm demonstrated good discriminatory capacity for identifying these fractures.
ARCHIVES OF OSTEOPOROSIS
(2021)
Review
Endocrinology & Metabolism
Sabrina E. Noel, Michelly P. Santos, Nicole C. Wright
Summary: Osteoporosis is a bone disease with racial and ethnic disparities in bone outcomes. Variations in bone density, prevalence of osteoporosis and fractures, as well as disparities in screening and treatment exist across different racial and ethnic groups. Suboptimal osteoporosis management and postfracture care may be experienced by non-Hispanic black, Hispanic, and Asian populations, highlighting the need for additional population-based studies.
JOURNAL OF BONE AND MINERAL RESEARCH
(2021)
Article
Geriatrics & Gerontology
Nitzan Burrack, Laura A. Hatfield, Pieter Bakx, Amitava Banerjee, Yu-Chin Chen, Christina Fu, Carlos Godoy Junior, Michal Gordon, Renaud Heine, Nicole Huang, Dennis T. Ko, Lisa M. Lix, Victor Novack, Laura Pasea, Feng Qiu, Therese A. Stukel, Carin Uyl-de Groot, Bheeshma Ravi, Saeed Al-Azazi, Gabe Weinreb, Peter Cram, Bruce E. Landon
Summary: This study retrospectively analyzed the treatment patterns and outcomes of older adults hospitalized with hip fracture in Taiwan, the US, Canada, England, the Netherlands, and Israel between 2011 and 2018. The study found significant variations in mortality, surgical approaches, and health system performance measures across different countries, highlighting the need for further research to inform evidence-based surgical approaches.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2023)
Article
Geriatrics & Gerontology
Smita Nayak, Andrea Singer, Susan L. Greenspan
Summary: The study evaluated the cost-effectiveness of secondary fracture prevention intervention for Medicare beneficiaries, showing that the intervention was more effective and less expensive than usual care. It resulted in cost savings and increased quality-adjusted life-years, making it a recommended strategy for improving outcomes and reducing healthcare costs.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2021)
Article
Endocrinology & Metabolism
A. Shah, S. Hawley, D. S. Inman, C. Cooper, E. Fagan, A. Johansen, A. Judge
Summary: Variation across geographical regions of England in operations and 30-day mortality following hip fracture was observed, particularly for patients with trochanteric hip fractures. The study suggests the need for further investigation into other aspects of post-hip fracture care to understand the regional differences.
OSTEOPOROSIS INTERNATIONAL
(2021)
Article
Endocrinology & Metabolism
Marko T. Korhonen, Urho M. Kujala, Jyrki Kettunen, Olga V. Korhonen, Jaakko Kaprio, Seppo Sarna, Timo Tormakangas
Summary: Maintenance of vigorous exercise habits from young to old age is considered protective against hip fractures. This study found that continuing high-intensity exercise in old age is associated with a lower hazard rate of hip fractures, although this protective effect diminishes with age.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Geriatrics & Gerontology
Antony Johansen, Opinder Sahota, Frances Dockery, Alison J. Black, Alasdair M. J. Maclullich, M. Kassim Javaid, Emer Ahern, Celia L. Gregson
Summary: Currently, in the UK and Ireland, the majority of patients with hip fracture do not receive bone protection medication, despite the evidence showing that intravenous zoledronate significantly reduces refracture risk. This paper discusses the clinical uncertainties, doubts over the evidence base, and practical concerns that contribute to the variability in the use of intravenous zoledronate following a hip fracture. It provides expert consensus guidance to assist healthcare professionals in establishing local protocols to deliver this highly clinically and cost-effective treatment to reduce costly re-fractures in this vulnerable population.
Review
Public, Environmental & Occupational Health
Yaohui Yu, Yudan Wang, Xiaoli Hou, Faming Tian
Summary: Hip fracture is a devastating type of osteoporosis-related fracture with high socioeconomic burden, morbidity rate, and mortality rate. This review summarizes the recent advances in identifying emerging risk or protective factors for hip fracture, such as differences in medical services, diseases, drugs, mechanical load, neuromuscular mass, genes, blood types, and cultural differences. It discusses associated factors, effective prevention measures, and issues requiring further investigation, including the influencing mechanism of risk factors and the confirmation or correction of emerging factors.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Endocrinology & Metabolism
Fran Llopis-Cardona, Carmen Armero, Isabel Hurtado, Anibal Garcia-Sempere, Salvador Peiro, Clara L. Rodriguez-Bernal, Gabriel Sanfelix-Gimeno
Summary: Osteoporotic hip fractures in older people may increase the risk of subsequent hip fractures and death. This study estimated the cumulative incidence of recurrent hip fracture and death in the Valencia region. The findings showed that women had a higher incidence of recurrent hip fracture than men, while men had a higher risk of death.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Endocrinology & Metabolism
Jonas Banefelt, Jen Timoshanko, Emma Soreskog, Gustaf Ortsater, Alireza Moayyeri, Kristina E. Akesson, Anna Spangeus, Cesar Libanati
Summary: The study confirmed a strong association between BMD T-score and fracture risk, with consistent marginal changes observed in bisphosphonate-treated patients. The results extend evidence from clinical trials, demonstrating the suitability of total hip BMD as a meaningful outcome for the clinical management of patients with osteoporosis.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Public, Environmental & Occupational Health
Sobia S. Janjua, Helen F. Boardman, Arvind Sami, Antony Johansen, Li Shean Toh, Kassim M. Javaid
Summary: The dispensing rate of Anti-Osteoporosis Medication (AOM) is related to the prevalence of risk factors and hip fracture incidence in the local population. Areas with a higher proportion of active adults and higher incidence of hip fracture have lower rates of AOM dispensing. Multidisciplinary services should be developed to address this care gap, considering local population risk factors.
PHARMACOEPIDEMIOLOGY AND DRUG SAFETY
(2023)
Article
Endocrinology & Metabolism
Rafael Pinedo-Villanueva, Edward Burn, Christopher Maronga, Cyrus Cooper, M. Kassim Javaid
Summary: Osteoporotic-related fractures lead to patient disability and burden on health care systems. Fracture liaison services (FLSs) provide effective secondary fracture prevention, but are not widely available. This study developed an economic model to estimate the benefits and budget impact of FLSs and support their international implementation.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Article
Geriatrics & Gerontology
Leena Elhussein, Annika M. M. Jodicke, Ying He, Antonella Delmestri, Danielle E. Robinson, Victoria Y. Strauss, Daniel Prieto-Alhambra
Summary: This study identified three distinct groups of older people with complex health needs based on healthcare resource use or frailty. Compared to the hospitalisation cohort, the frailty and polypharmacy cohorts had more comorbidities and higher use of preventive therapies.
Article
Medicine, General & Internal
Joanna McLaughlin, Ruth Kipping, Amanda Owen-Smith, Hugh McLeod, Samuel Hawley, J. Mark Wilkinson, Andrew Judge
Summary: This study aimed to assess the impact of BMI policies on access to hip replacement surgery in England. The study found that the implementation of BMI policies led to a decrease in surgery rates, while areas without policies saw an increase in rates, exacerbating health inequalities. It is recommended to no longer use BMI policies involving extra waiting time or mandatory BMI thresholds to reduce access to hip replacement surgery.
Article
Orthopedics
Rafael Pinedo-Villanueva, Spyros Kolovos, Edward Burn, Antonella Delmestri, Lindsay K. K. Smith, Andrew Judge, Sarah R. R. Kingsbury, Martin H. H. Stone, Philip G. G. Conaghan
Summary: Follow-up visits after primary hip or knee replacement surgery have been recommended, but their benefits have not been specifically examined. This study found that patients attending follow-up visits had a higher risk of revision surgery.
BMC MUSCULOSKELETAL DISORDERS
(2023)
Article
Orthopedics
Hasan R. Mohammad, Andrew Judge, David W. Murray
Summary: The study examined the performance of cemented and cementless UKRs in different BMI groups. It found that higher-BMI groups had higher revision rates for cemented UKRs, but not for cementless UKRs. Cementless fixation was associated with reduced long-term revision rates and lower risks of aseptic loosening and pain in the obese group.
JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME
(2023)
Article
Geriatrics & Gerontology
Samuel Hawley, Dominic Inman, Celia L. Gregson, Michael Whitehouse, Antony Johansen, Andrew Judge
Summary: This study aims to identify risk factors and examine associations with returning home or recovery of mobility among hip fracture patients who have normal preoperative cognition. The results show that patients with postoperative delirium are less likely to return home or regain outdoor mobility. Multiple factors, including deficits in preoperative cognition and malnutrition, increase the risk of delirium, while the use of preoperative nerve blocks reduces the risk. Understanding the importance of preventing postoperative delirium and identifying high-risk patients can potentially improve outcomes for hip fracture patients.
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2023)
Article
Orthopedics
Hasan Raza Mohammad, Andrew Judge, Christopher Dodd, David Murray
Summary: This study assessed the effects of pre and post-operative activity levels on cementless Unicompartmental Knee Replacement (UKR), and found that increasing post-operative activity did not increase revision rates but was associated with better post-operative function. Therefore, activity should not be restricted before or after cementless UKR.
Article
Orthopedics
Hasan R. Mohammad, Karen Barker, Andrew Judge, David W. Murray
Summary: A matched study was performed to compare the periprosthetic fracture rates after TKR and UKR. The fracture rate after UKR was approximately twice as high as that after TKR within the first 3 months postoperatively. However, over the first 10 years, the cumulative fracture rate after TKR was almost twice as high as that after UKR. Fracture rates after both UKR and TKR were higher in women, patients aged 75 or older, and patients with normal weight.
JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME
(2023)
Article
Endocrinology & Metabolism
M. Kassim Javaid, M. Calo, S. Wullich, Z. Mohsin, E. Castro Osorio, A. Medina Orjuela, C. Arteaga Unigarro, L. Mendez-Sanchez, J. Torres Naranjo, L. Tikle Vieira, K. Kuraoka Tutiya, A. Manoel Inacio, A. Olascoaga-Gomez de Leon, J. Carlos Viveros Garcia, C. Habib, F. Subies, J. P. Guyot, M. Diehl, G. Carabelli, A. Soulie, C. Cooper
Summary: By implementing the mentorship programme for fracture liaison service (FLS) in Latin America, 64 FLS were established and 17,205 patients were covered.
OSTEOPOROSIS INTERNATIONAL
(2023)
Article
Endocrinology & Metabolism
M. K. Javaid, R. Pinedo-Villanueva, A. Shah, Z. Mohsin, M. Hiligsmann, A. Motek-Soulie, N. R. Fuggle, P. Halbout, C. Cooper
Summary: The Capture the Fracture & REG; Partnership (CTF-P) is a unique collaboration that aims to enhance the implementation of effective fracture liaison services (FLSs) with a good patient experience. It has provided valuable resources to specific countries and the broader FLS community in order to improve the initiation, effectiveness, and sustainability of FLS in various healthcare settings.
OSTEOPOROSIS INTERNATIONAL
(2023)
Article
Multidisciplinary Sciences
Junqing Xie, Yuliang Feng, Danielle Newby, Bang Zheng, Qi Feng, Albert Prats-Uribe, Chunxiao Li, Nicholas J. Wareham, R. Paredes, Daniel Prieto-Alhambra
Summary: The study examined the association between genetic predisposition, lifestyle factors, and the risk of post-COVID-19 cardiovascular and thromboembolic events (CVE). The results showed that higher polygenic risk scores were associated with increased risks of atrial fibrillation, coronary artery disease, venous thromboembolism, and ischemic stroke. However, a healthier lifestyle was consistently associated with a reduction in all outcomes. These findings highlight the independent effects of host genetics and lifestyle on the occurrence of CVE complications in COVID-19 patients.
NATURE COMMUNICATIONS
(2023)
Article
Public, Environmental & Occupational Health
Tafadzwa Madanhire, Samuel Hawley, Ethel Dauya, Tsitsi Bandason, Ruramayi Rukuni, Rashida A. Ferrand, Celia L. Gregson
Summary: The study aims to determine the prevalence and severity of self-reported menopause symptoms in African women and evaluate their relationship with health-related quality of life. The study also explores factors associated with menopause symptoms.
Article
Medicine, General & Internal
Tomas Urdiales, Francesco Dernie, Marti Catala, Albert Prats-Uribe, Clara Prats, Daniel Prieto-Alhambra
Summary: In England, there are inequalities in testing, vaccination, and COVID-19 outcomes according to ethnicity. Compared with whites, Asian participants have an increased risk of infection and admission, while black participants have almost double the hospitalization risk and a lower vaccine uptake. Chinese participants, on the other hand, have a lower risk of testing positive, testing negative, and receiving vaccination.
Article
Geriatrics & Gerontology
Petra Baji, Rita Patel, Andrew Judge, Antony Johansen, Jill Griffin, Tim Chesser, Xavier L. Griffin, Muhammad K. Javaid, Estela C. Barbosa, Yoav Ben-Shlomo, Elsa M. R. Marques, C. L. Gregson
Summary: This study aimed to identify hospital-level organisational factors associated with long-term patient outcomes and costs after hip fracture. The study found that variations in hip fracture care delivery between hospitals can impact patient outcomes and health costs. The results can inform initiatives to improve the effectiveness and efficiency of hip fracture services.
LANCET HEALTHY LONGEVITY
(2023)