Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 21, Issue 36, Pages 12606-12610Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201502487
Keywords
aerobic oxidation; amines; benzimidazoles; CH functionalization; homogeneous catalysis
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Funding
- ADRAPHARM (Association pour le Developpement de la Recherche Appliquee a la Pharmacologie)
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Aerobic oxidative CH functionalization of primary aliphatic amines has been accomplished with a biomimetic cooperative catalytic system to furnish 1,2-disubstituted benzimidazoles that play an important role as drug discovery targets. This one-pot atom-economical multistep process, which proceeds under mild conditions, with ambient air and equimolar amounts of each coupling partner, constitutes a convenient environmentally friendly strategy to functionalize non-activated aliphatic amines that remain challenging substrates for non-enzymatic catalytic aerobic systems.
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