Journal
ORGANIC LETTERS
Volume 18, Issue 6, Pages 1322-1325Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.6b00260
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Funding
- NSFC [21372086, 21422204]
- Guangdong NSF [2014A030313229]
- SRF for ROCS, State Education Ministry
- Fundamental Research Funds for the Central Universities
- SCUT
- China Postdoctoral Science Foundation [2015M582378]
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An efficient proton/metal-catalyzed tandem benzofuran annulation/carbene transfer reaction for the synthesis of various benzofuryl-substituted cyclopropanes and cycloheptatrienes has been developed. The reaction was proposed to proceed through two key intermediates, o-quinone methide (o-QM) and benzofuryl carbene. The DFT-based computational studies indicated that the reaction was initiated through the dehydration of o-HBA via a Bronsted acid mediated proton shuttle transition state, forming the key intermediate o-QM.
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