Journal
ORGANIC LETTERS
Volume 18, Issue 13, Pages 3102-3105Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.6b01253
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Funding
- EPSRC
- GlaxoSmithKline
- CNPq
- Engineering and Physical Sciences Research Council [1636131, GR/T04113/01] Funding Source: researchfish
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Treatment of homoallylic alcohols or carboxylic acids with malonoyl peroxide 1 provides a stereoselective method for the preparation of tetrahydrofurans, gamma-lactones, and isobenzofuranones in 44-82% yield and up to 27:1 trans selectivity. Application of this simple and effective heterocyclization in the synthesis of the antidepressant citalopram is also described.
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