☆ 4.8 Article

Cobalt-Catalyzed Carbonylation of C(sp2)-H Bonds with Azodicarboxylate as the Carbonyl Source

ORGANIC LETTERS (2016)

Journal

ORGANIC LETTERS

Volume 18, Issue 22, Pages 5960-5963

Publisher

AMER CHEMICAL SOC

DOI: 10.1021/acs.orglett.6b03111

Keywords

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Categories

Chemistry, Organic

Funding

Chinese NSF [81430080, 81373277]
Major State Basic Research Development Program [2015CB910603]
Program of Shanghai Subject Chief Scientist [16XD1404600]

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Abstract

A novel and efficient approach for the C(sp(2))-H bond carbonylation of benzamides has been developed using stable and inexpensive Co(OAc)(2).4H(2)O as the catalyst and the commercially available and easily handling azodicarboxylates as the nontoxic carbonyl source. A broad range of substrates bearing diverse functional groups were tolerated. This is the first example where cobalt-catalyzed C(sp(2))-H bond carbonylation occurs with azodicarboxylate as the carbonyl source.

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