Journal
ORGANIC LETTERS
Volume 18, Issue 18, Pages 4451-4453Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.6b01812
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Funding
- China Scholarship Council
- National Natural Science Foundation of China [201506270049]
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The strategy of secondary interaction enables enantioselectivity for homogeneous hydrogenation. By in, troducing hydrogen bonding of substrates with thiourea from the ligand, alpha,beta-unsaturated carbonyl, compounds, such as amides and esters, are hydrogenated with high enantiomeric excess. The substrate scope for this chemical transformation is broad with various substituents at the beta-position. Control experiments revealed that each unit of the ligand ZhaoPhos is irreplaceable. No nonlinear effect was observed for this Rh/ZhaoPhos-catalyzed asymmetric hydrogenation.
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