Journal
ORGANIC LETTERS
Volume 18, Issue 24, Pages 6428-6431Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.6b03326
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Funding
- West Virginia University
- NSF [CHE-1559654]
- NSF Major Research Instrumentation (MRI) Program [CHE-1228336, CHE-1336071, CHE-1427136]
- Direct For Mathematical & Physical Scien [1427136, 1559654] Funding Source: National Science Foundation
- Division Of Chemistry [1427136, 1559654] Funding Source: National Science Foundation
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Regioselective copper-catalyzed boracarboxylation of vinyl arenes with bis(pinacolato)diboron and carbon dioxide has been achieved. New boron-functionalized alpha-aryl carboxylic acids, including nonsteroidal anti-inflammatory drugs (NSAIDs), are obtained in moderate to excellent yields. The synthetic utility of the transformation was shown through subsequent derivatization of the carbon-boron bond yielding formal hydroxy- and fluorocarboxylation products as well as anionic difluoroboralactones.
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