Journal
ORGANIC LETTERS
Volume 18, Issue 21, Pages 5632-5635Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.6b02870
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Funding
- National Natural Science Foundation of China [21425415, 21274058]
- National Basic Research Program of China [2015CB856303]
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Traceless heterocycle synthesis based on transition metal-catalyzed C-H functionalization is synthetically appealing but has been realized only in monodentate directing systems. Bidentate directing systems allow for the achievement of high catalytic reactivity without the need for a high-cost privileged ligand. The first bidentate directing-enabled, traceless heterocycle synthesis is demonstrated in the cobalt-catalyzed synthesis of isoquinolines via 2-hydrazinylpyridine-directed C-H coupling/cyclization with alkynes. Convenient directing group installation through a ubiquitously present ketone group allows synthetic elaboration for complex molecules.
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