Journal
ORGANIC LETTERS
Volume 18, Issue 12, Pages 2793-2795Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.6b00994
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Funding
- NSF [CCE 1265591]
- Caltech
- Amgen
- Swiss National Science Foundation (SNSF)
- Direct For Mathematical & Physical Scien
- Division Of Chemistry [1265591] Funding Source: National Science Foundation
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An insertion of arenes into both imides and anhydrides via reactive aryne intermediates presented. The reaction is performed under exceptionally mild conditions, and the corresponding ketoamide products are amenable to derivatization to deliver a variety of synthetically useful motifs such:as quinolones, indoles, and ketoanilines.
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