Journal
ORGANIC LETTERS
Volume 18, Issue 22, Pages 5828-5831Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.6b02813
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Funding
- National Natural Science Foundation of China [NSF-21502150, 21402154]
- Chinese Universities Scientific Fund [2452016093]
- Youth Training Programme of Northwest AF University [Z111021404]
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An efficient two component cydoaddition reaction to synthesize various substituted quinoline derivatives was developed. Ynone 1 was functionalizated by N-oxide attacking the C3-oxetium site and C3-site regioselectively to give 3 and 4. Analogues 3k and 4v have a high binding constant with Hg2+ in CH3CN.
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