Journal
ORGANIC LETTERS
Volume 18, Issue 8, Pages 1732-1735Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.6b00378
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- AbbVie
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A simplified Boc deprotection using a high-temperature flow reactor is described. The system afforded the qualitative yield of a wide variety of deprotected substrates within minutes using acetonitrile as the solvent and without the use of acidic conditions or additional workups. Highly efficient, multistep reaction sequences in flow are also demonstrated wherein no extraction or isolation was required between steps.
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