Journal
ORGANIC LETTERS
Volume 18, Issue 15, Pages 3850-3853Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.6b01862
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Funding
- National Natural Science Foundation of China [21472178, 21232007]
- National Key Basic Research Program of China [2014CB931800]
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An unprecedented application of trifluoromethanesulfonyl hydrazides as trifluoromethylating agents has been demonstrated in two vicinal difunctionalization reactions of terminal alkenes: the copper-catalyzed three-component vicinal chlorotrifluoromethylation of arylakenes with TfNHNHBoc and NaCl and the tandem trifluorornethylation/cyclization of N-arylacrylamides with TfNHNHBoc. The reactions, proceeded in the presence of inexpensive oxidants under mild conditions and provided a range of structurally diverse trifluoromethyl-containing compounds with high regioselectivity.
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