4.8 Article

Diamination of Domino Aryne Precursor with Sulfonamides

Journal

ORGANIC LETTERS
Volume 18, Issue 13, Pages 3130-3133

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.6b01334

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Funding

  1. NSFC [21372268, 21372266]
  2. Fundamental Research Funds for the Central Universities [106112016CDJZR228806]

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The reaction of a domino aryne precursor with sulfonamides efficiently afforded both 1,3-diaminobenzenes and trisubstituted 1,3-diaminobenzenes by simply varying the reaction conditions. Mechanistic study supports the sequential formation of two transient aryne intermediates involved in-the reaction.

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