Journal
ORGANIC LETTERS
Volume 18, Issue 18, Pages 4546-4549Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.6b02186
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Funding
- National Science Foundation of China [21572027, 21372267]
- [2014M562278]
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The transition-metal-free multicomponent coupling of arynes, anilines, and ethylglyoxylate, proceeding via an inverse electron-demand aza Diels-Alder cycloaddition and N-arylation, has been demonstrated. This protocol allows rapid access to N-aryl dihydrophenanthridine derivatives in moderate to high yields at room temperature from readily available starting materials. In addition, an unprecedented fluoride induced annulation of ethyl(arylimino)acetates led to the formation of highly functionalized oxoimidazolidine derivatives in good yields under mild conditions.
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