4.8 Article

A [4+1] Cyclative Capture Access to Indolizines via Cobalt(III)-Catalyzed Csp2-H Bond Functionalization

Journal

ORGANIC LETTERS
Volume 18, Issue 18, Pages 4742-4745

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.6b02421

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Funding

  1. NSFC [21372085]
  2. National Key Research Program of China [2016YFA0602900]
  3. Science and Technology Program of Guangzhou [156300075]

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A Co(III)-catalyzed [4 + 1] cycloaddition of 2-arylpyridines or 2-alkenylpyridines with aldehydes through Csp(2)-H bond activation has been developed. This protocol provides a facile approach to structurally diverse indolizines including benzoindolizines with a broad range of functional group tolerance.

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