4.8 Article

Pd(II)-Catalyzed C3-Selective Arylation of Pyridine with (Hetero)arenes

Journal

ORGANIC LETTERS
Volume 18, Issue 4, Pages 744-747

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.5b03712

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Funding

  1. Scripps Research Institute
  2. NIH (NIGMS) [1R01 GM102265]
  3. NSFC [21302029]
  4. Fundamental Research Funds for the Central Universities [HIT.NSRIF.2014064]
  5. Heilongjiang Postdoctoral Science Foundation [LBH-Z14104]

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Palladium catalyzed, nondirected C3-selective arylation of pyridines with arenes and heteroarenes in the presence of 1,10-phenanthroline as the ligand has been developed. The optimized conditions allow for a highly C3-selective arylation of pyridines, affording various 3,3'-bipyridines and 3-arylpyridines.

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