Synthesis and evaluation of influenza A viral neuraminidase candidate inhibitors based on a bicyclo[3.1.0]hexane scaffold

Oseltamivir Analogues Bearing N-Substituted Guanidines as Potent Neuraminidase Inhibitors

(2014) Caitlin A. Mooney et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of N-Substituted Oseltamivir Derivatives as Potent and Selective Inhibitors of H5N1 Influenza Neuraminidase

(2014) Yuanchao Xie et al.   JOURNAL OF MEDICINAL CHEMISTRY

Exploitation of the Catalytic Site and 150 Cavity for Design of Influenza A Neuraminidase Inhibitors

(2013) Pal John Pal Adabala et al.   JOURNAL OF ORGANIC CHEMISTRY

Chemical Insight into the Emergence of Influenza Virus Strains That Are Resistant to Relenza

(2013) Fahimeh S. Shidmoossavee et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The Influence of 150-Cavity Binders on the Dynamics of Influenza A Neuraminidases as Revealed by Molecular Dynamics Simulations and Combined Clustering

(2013) Kyle T. Greenway et al.   PLoS One

Induced opening of influenza virus neuraminidase N2 150-loop suggests an important role in inhibitor binding

(2013) Yan Wu et al.   Scientific Reports

Structural basis for a class of nanomolar influenza A neuraminidase inhibitors

(2013) Philip S. Kerry et al.   Scientific Reports

Recent progress in structure-based anti-influenza drug design

(2012) Juan Du et al.   DRUG DISCOVERY TODAY

Influenza neuraminidase inhibitors: antiviral action and mechanisms of resistance

(2012) Jennifer L. McKimm-Breschkin   Influenza and Other Respiratory Viruses

Transition State Analysis of Vibrio cholerae Sialidase-Catalyzed Hydrolyses of Natural Substrate Analogues

(2012) Jefferson Chan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Replication inhibition activity of carbocycles related to oseltamivir on influenza A virus in vitro

(2011) Masahiro Niikura et al.   ANTIVIRAL RESEARCH

Development of a Concise Synthesis of (−)-Oseltamivir (Tamiflu)

(2011) Barry M. Trost et al.   CHEMISTRY-A EUROPEAN JOURNAL

Peramivir: Another Tool for Influenza Treatment?

(2011) S. Jain et al.   CLINICAL INFECTIOUS DISEASES

Turnover Is Rate-Limited by Deglycosylation for Micromonospora viridifaciens Sialidase-Catalyzed Hydrolyses: Conformational Implications for the Michaelis Complex

(2011) Jefferson Chan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Mechanism of 150-cavity formation in influenza neuraminidase

(2011) Rommie E. Amaro et al.   Nature Communications

Carbocycles Related to Oseltamivir as Influenza Virus Group-1-Specific Neuraminidase Inhibitors. Binding to N1 Enzymes in the Context of Virus-like Particles

(2010) Sankar Mohan et al.   JOURNAL OF MEDICINAL CHEMISTRY

The binding properties of the H5N1 influenza virus neuraminidase as inferred from molecular modeling

(2010) Michal Raab et al.   JOURNAL OF MOLECULAR MODELING

A direct NMR method for the measurement of competitive kinetic isotope effects

(2010) Jefferson Chan et al.   Nature Chemical Biology

Novel sialic acid derivatives lock open the 150-loop of an influenza A virus group-1 sialidase

(2010) Santosh Rudrawar et al.   Nature Communications

Characterizing Loop Dynamics and Ligand Recognition in Human- and Avian-Type Influenza Neuraminidases via Generalized Born Molecular Dynamics and End-Point Free Energy Calculations

(2009) Rommie E. Amaro et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Hydrolytic Deallylation ofN-Allyl Amides Catalyzed by PdIIComplexes

(2008) Naoya Ohmura et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY