Article
Pharmacology & Pharmacy
Fen Zheng, Wei Du, Minggang Yang, Kaige Liu, Shanming Zhang, Long Xu, Yong Wen
Summary: In this study, a reactive oxygen species (ROS)-responsive innate antibacterial supramolecular gel was developed using phenylalanine and hydrazide as gelators. The gel showed excellent inherent antibacterial properties and could release antibiotics in response to ROS. It also exhibited good biocompatibility and the ability to promote cell proliferation. This ROS-responsive supramolecular gel holds great potential as a novel antibacterial agent for treating antibiotic-resistant bacterial infections and preventing the development of bacterial resistance.
Article
Polymer Science
Paolo Ravarino, Nadia Di Domenico, Marianna Barbalinardo, Davide Faccio, Giuseppe Falini, Demetra Giuri, Claudia Tomasini
Summary: The addition of fluorine atoms improves the properties of the gelators, including gelation ability, rheological properties, transparency, and biocompatibility.
Article
Chemistry, Physical
Xue-Wen Shi, Wu-Xiu Liu, Kenta Matsumoto, Xiang-Qian Li, Ban-Peng Cao, Haixin Ding, Hiroaki Okamoto, Qiang Xiao
Summary: Novel multi-functional compounds based on Schiff base unit have been synthesized, which can form gels with different solvents. The self-assembly pattern of these compounds has been investigated, showing a sensitive and selective turn-off fluorescence response with Cu2+. Furthermore, the compounds exhibit emission quenching and recovery behavior upon reaction with trifluoroacetic acid or triethylamine, providing a new pathway for the detection of Cu2+, TFA, and TEA using stimuli-responsive fluorescent materials with aggregation-induced emission effect.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
(2023)
Article
Chemistry, Physical
Wangkhem P. Singh, Laishram Robindro Singh, Rajkumar S. Singh
Summary: This study describes the design, synthesis, and visual fluoride ion detection of a new small-molecule gelator. A triphenylsilyl group in the gelator can be easily removed in the presence of fluoride ion, enabling visual detection. Two different routes were investigated for fluoride ion detection, including quantification based on gel degradation times and visual analysis of gel formation suppression. The new gelator has superior performance and detection limit compared to existing gelation-based methods. The gels were fully characterized using various techniques.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Polymer Science
Khalid Azyat, Darren Makeiff, Bradley Smith, Mickie Wiebe, Steve Launspach, Ashley Wagner, Marianna Kulka, Nicolas Godbert
Summary: Mono-N-alkylated primary oxalamide derivatives with different sized branched alkyl tail-groups are effective gelators for various organic solvents. The molecular structures of the tail-groups have significant effects on gel properties in select solvents. These gelators show no cytotoxicity and are suitable for biomedical applications.
Article
Chemistry, Multidisciplinary
Jianye Kang, Xuewei Zhang, Xinyu Yang, Xuhao Yang, Shutao Wang, Wenlong Song
Summary: This study develops a mucosa-inspired electro-responsive hydrogel with the synergy between electro-responsive silk fibroin supramolecular non-covalent networks and covalent polyacrylamide and polyvinyl alcohol polymer networks. The hydrogel exhibits a partial gel-sol transition under an electric field and can mimic the mucus-secreting capability to regulate lubrication. It is a universal strategy to construct an electro-responsive hydrogel using an electro-responsive supramolecular network. This mucosa-inspired electro-responsive hydrogel offers a promising method for designing soft actuators or robots that can regulate lubrication using an electric strategy.
ADVANCED MATERIALS
(2023)
Article
Spectroscopy
Shang Wu, Pengwei Jiang, Ning Ding, Qiang Hu, Xiangtao Yan, Jutao Liu, Yanbin Wang, Hong Zhang, Peilin Yuan, Quanlu Yang
Summary: A novel gelator molecule MN based on quinolone has been successfully synthesized, forming a supramolecular gel OMN with aggregation-induced emission in iso-Propyl alcohol. The supramolecular organogel OMN showed ultrasensitive detection of Fe3+ and Cu2+ in aqueous medium and fluorescent quenching at 427 nm. The sensing mechanism between the supramolecular gel and metal ions was fully investigated, and a responsive thin film based on OMN was prepared for multi-stimuli-responsive fluorescent display materials.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2021)
Article
Chemistry, Physical
Olamilekan Joseph Ibukun, Milan Gumtya, Surajit Singh, Ananda Shit, M. Douzapau, Debasish Haldar
Summary: This study presents a simple protocol for synthesizing ferrocene substituted benzoic acid and a highly efficient approach for producing a ferrocene appended peptide mimetic. The peptide mimetic adopts an extended conformation and self-aggregates to form dimers through intermolecular hydrogen bonds, which is supported by both X-ray single crystal analysis and mass spectrometry. The peptide mimetic also forms a stimulus-responsive metallogel and exhibits pH sensitivity.
MOLECULAR SYSTEMS DESIGN & ENGINEERING
(2023)
Article
Nanoscience & Nanotechnology
Li Ding, Jingyi Zhang, Quan Shu, Siyong Liu, Shouhu Xuan, Xinglong Gong, Dongsheng Zhang
Summary: Shape-programmable magnetic materials and self-sensing conductive materials have the potential to achieve advanced actuation functions at small scales. This work presents a facile preparation method for self-sensing magnetism-responsive anisotropic films (SMAF) without the need for external magnetic field generators. The developed films can achieve complex chain-orientation structures and distinguish different actuation modes, contributing to the exploration of directionally responsive applications in smart actuating systems and soft robotics.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Analytical
Qi Liu, Shushu Ding, Rui Gao, Guoyue Shi, Anwei Zhu
Summary: A smart copolymer modified nanochannel was designed to mimic the structure and mechanism of K-ATP channels, achieving ATP responsiveness and demonstrating a possible mechanism for ATP gating.
ANALYTICA CHIMICA ACTA
(2021)
Article
Chemistry, Multidisciplinary
Feihong Lu, Yi Chen, Boqiao Fu, Shigui Chen, Lu Wang
Summary: A stimuli-responsive supramolecular polymer network has been created using host-guest interactions, and its dissociation through the addition of competitive molecules and heating results in significant changes in its physical properties.
CHINESE CHEMICAL LETTERS
(2022)
Article
Chemistry, Analytical
Sumit Ghosh, Palash Jana, Kumaresh Ghosh
Summary: Napthalimide-linked pyridylazo derivatives 1 and 2 have been synthesized and compound 1 acts as a gelator in DMF-H2O mixture. The brown gel of 1 shows selective sensing of CN- ions while compound 2 does not exhibit gelation properties under identical conditions.
ANALYTICAL METHODS
(2021)
Article
Chemistry, Applied
Pengwei Jiang, Shang Wu, Qiang Hu, Xiangtao Yan, Jutao Liu, Shuaishuai Fu, Lan Wu, Xiangfei Zhao, Quanlu Yang
Summary: This article introduces a novel organogelator based on naphthalimide, which can detect Fe3+ and H2PO4 through fluorescence and has high adsorption capacity.
Article
Chemistry, Applied
Ziqiang Zhang, Kuo Lv, Cheng Liu, Yuan Yue, Xiqiao Yang, Liuyang Jin, Huan Xiao, Chu Yao, Jingbo Sun, Ran Lu
Summary: Four fluorescent low molecular weight gelators based on benzoxazole or benzothiazole functionalized pyrimidine were designed and synthesized, which could form stable supramolecular gels in an alcohol/water mixture. The gel formation was driven by hydrogen bonding, van der Waals forces, and weak interaction. The gel collapsed under UV light due to the [2 + 2]-cycloaddition reaction, and the fluorescent of the xerogel film could be quenched by volatile acids while enhanced in the solution after acid addition. The nano-fiber assembled via gel formation could be used for fluorescent imaging of latent fingerprints.
Article
Chemistry, Physical
Shengzhen Hou, Jian Zhang, Bo Huang, Xiujun Wang, Pengyao Xing
Summary: This work demonstrates the fabrication of binary gels through self-sorting assembly between beta-cyclodextrin and the second gelators, which exhibit significant changes in transparency in response to solvent vapor and temperature. The opaque gels formed by mixing beta-cyclodextrin and clay minerals in dimethylformamide and water become highly transparent upon exposure to specific solvent environments due to the host-guest complexation between beta-cyclodextrin and organic solvent vapors. Furthermore, certain organic solvents induce a transformation of the gel fibers into bulky crystals, resulting in a slight enhancement of the mechanical strength of the binary gels.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2022)
Article
Chemistry, Multidisciplinary
Le Fang, Wei-Tao Gong, Manivannan Kalavathi Dhinakaran, Li Shang, Gui-Ling Ning
Article
Chemistry, Multidisciplinary
Hassan Mehdi, Hongchang Pang, Weitao Gong, Ali Wajahat, Kalavathi Dhinakaran Manivannan, Shaheen Shah, Jun-wei Ye, Guiling Ning
SUPRAMOLECULAR CHEMISTRY
(2017)
Article
Polymer Science
Manivannan Kalavathi Dhinakaran, Weitao Gong, Yue Yin, Ali Wajahat, Xiaojun Kuang, Leyong Wang, Guiling Ning
Article
Chemistry, Physical
Xiao-jun Kuang, Ali Wajahat, Wei-tao Gong, Manivannan Kalavathi Dhinakaran, Xiao-han Li, Gui-ling Ning
Article
Chemistry, Multidisciplinary
Hewei Yan, Junkai Ma, Fei Zhu, Jiaxin Quan, Manivannan Kalavathi Dhinakaran, Haibing Li
CHEMISTRY-AN ASIAN JOURNAL
(2020)
Article
Chemistry, Multidisciplinary
Sheng Yu, Nsengiyumva Gilbert, Fei Zhu, Manivannan Kalavathi Dhinakaran, Feng Liang, Haibing Li
Article
Chemistry, Multidisciplinary
Jiaxin Quan, Fei Zhu, Manivannan Kalavathi Dhinakaran, Yingying Yang, Robert P. Johnson, Haibing Li
Summary: Inspired by the light-regulating capabilities of naturally occurring rhodopsin, a visible-light-regulated Cl- transport membrane channel has been constructed based on a supramolecular host-guest interaction. Utilizing the visible-light responsiveness of the host-guest interaction, ion transport can be regulated by visible light between ON and OFF states. This research may further understanding of biological ion transport behaviors and provide insights for visible-light-responsive ion transport devices.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Multidisciplinary
Ming Cheng, Fei Zhu, Siyun Zhang, Xingrou Zhang, Manivannan Kalavathi Dhinakaran, Haibing Li
Summary: By designing and constructing a novel nanochannel inspired by chloride channel protein, which has Cl- selectivity and can improve Cl- transport flux by adjusting the asymmetric degree, a high flux artificial ion channel has been successfully constructed for practical applications like microfluidic devices, sensors, and ion separation.
Article
Nanoscience & Nanotechnology
Ming Cheng, Fei Zhu, Weiwei Xu, Siyun Zhang, Manivannan Kalavathi Dhinakaran, Haibing Li
Summary: The creation of chiral OMS nanochannels by introducing L-alanine-pillar[5]arene host in achiral OMS has shown excellent selectivity in separating racemic drugs with high reusability and stability. The enantioselective separation mechanism was identified as molecular-recognition-adsorbed transport. This work demonstrates the significant potential of chiral OMS nanochannels for enantioselective separation.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Multidisciplinary
Siyun Zhang, Ming Cheng, Manivannan Kalavathi Dhinakaran, Yue Sun, Haibing Li
Summary: Inspired by biological antiporter proteins, artificial nanochannels with antiporter behavior were fabricated for chiral sensing and separation. Multiligand-modified asymmetric channels significantly enhanced chiral distinction and separation of naproxen enantiomers. The asymmetric modified multiligand was crucial for achieving robust enantiomer separation.
Review
Chemistry, Multidisciplinary
Weiwei Xu, Ming Cheng, Siyun Zhang, Qifa Wu, Zhuo Liu, Manivannan Kalavathi Dhinakaran, Feng Liang, Elena G. Kovaleva, Haibing Li
Summary: Chiral discrimination is an important process in supramolecular chemistry, playing a key role in biological systems and biochemical sensors. Currently, enantioselective identification of chiral molecules in artificial systems remains a challenging topic.
CHEMICAL COMMUNICATIONS
(2021)
Article
Chemistry, Multidisciplinary
Fei Zhu, Wenqian Wang, Fan Zhang, Manivannan Kalavathi Dhinakaran, Yingqian Wang, Rui Wang, Jing Cheng, Maria Eugenia Toimil-Molares, Christina Trautmann, Haibing Li
Summary: In this study, tryptophan enantiomers were utilized in artificial nanochannels to regulate the chiral selective transport of A beta proteins, with l-Trp channel showing effective selectivity for the transportation of A beta proteins. This could offer a new perspective for pathological studies of Alzheimer's disease.
CHEMICAL COMMUNICATIONS
(2021)
Article
Chemistry, Multidisciplinary
Fei Zhu, Shiliang Tan, Manivannan Kalavathi Dhinakaran, Jing Cheng, Haibing Li
CHEMICAL COMMUNICATIONS
(2020)
Article
Chemistry, Multidisciplinary
Qianqian Song, Longcan Mei, Xujie Zhang, Pingping Xu, Manivannan Kalavathi Dhinakaran, Haibing Li, Guangfu Yang
CHEMICAL COMMUNICATIONS
(2020)
Article
Chemistry, Multidisciplinary
Fei Zhu, Guanxing Yang, Manivannan Kalavathi Dhinakaran, Rui Wang, Miaomiao Song, Haibing Li
CHEMICAL COMMUNICATIONS
(2019)
Article
Chemistry, Organic
Faiza Diaba, Gisela Trenchs
Summary: The first violet light-mediated synthesis of gamma- and delta-lactams from N-alkenyl trichloroacetamides is reported in this paper. The reactions are conducted in tetrahydrofuran or 2-methyltetrahydrofuran as the sole solvent without catalysts or additives, under non-anhydrous conditions in an air atmosphere where the solvent serves as the radical initiator.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Article
Chemistry, Organic
Feroze Hussain, Sajjad Ahmed, Ashiq Hussain Padder, Qazi Naveed Ahmed
Summary: This study reports a novel and efficient one-pot synthesis method for mixed phosphorotrithioates, which does not require supplementary additives and shows broad applicability.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Article
Chemistry, Organic
Hyunjin Oh, Ikyon Kim
Summary: A new 1,2,4-triazole-pyrrolo[1,2-a]pyrazine hybrid system, 6-acylpyrrolo[1,2-a][1,2,4]triazolo[5,1-c]pyrazine, was synthesized using a catalyst-free method. This method involved sequential exposure of pyrrole-2-carbonitrile-derived substrates to DMF-DMA and acyl hydrazide, resulting in the formation of acylated pyrazine and 1,2,4-triazole rings, enabling the installation of various substituents at specific positions on the core skeleton.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Article
Chemistry, Organic
Ming Yan, Si-fan Wang, Yong-po Zhang, Jin-zhong Zhao, Zhuo Tang, Guang-xun Li
Summary: Here we developed an efficient photocatalytic approach for the convenient preparation of sulfinamides. The reaction allows for the gram-scale preparation of sulfinamides and the one-pot synthesis of various sulfonyl amides.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Article
Chemistry, Organic
Farzaneh Bandehali-Naeini, Zahra Tanbakouchian, Noushin Farajinia-Lehi, Nicolas Mayer, Morteza Shiri, Martin Breugst
Summary: Two tandem catalytic systems were developed for the synthesis of novel 3,4-disubstituted maleimides using the same Ugi adducts. Different maleimide structures can be synthesized using either Pd or Cu catalysis.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Article
Chemistry, Organic
Tanya Raghava, Anjan Chattopadhyay, Subhadeep Banerjee, Nivedita Sarkar
Summary: Amine substitution of two ortho fluorine atoms of tetrafluoroterephthalonitrile through SNAr chemistry is easily achievable. But further fluorine substitution is only possible under forcing conditions, yielding valuable fluorophores for bioimaging.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Review
Chemistry, Organic
Anju Chadha, Santosh Kumar Padhi, Selvaraj Stella, Sowmyalakshmi Venkataraman, Thangavelu Saravanan
Summary: Alcohol dehydrogenases are enzymes that use cofactors for oxidation or reduction reactions of alcohols or carbonyl compounds. They are utilized in green chemistry and have applications in the production of pharmaceuticals. Recombinant enzymes have solved the challenge of producing purified enzymes in large quantities. Engineered alcohol dehydrogenases have been used in asymmetric synthesis in industry. Various methods have been established for regenerating expensive cofactors to make the enzymatic process more efficient and economically viable.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)