An atom-efficient and convergent approach to the preparation of NS5A inhibitors by C–H activation

Potent bisimidazole-based HCV NS5A inhibitors bearing annulated tricyclic motifs

(2014) Min Zhong et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The Discovery of Potent Nonstructural Protein 5A (NS5A) Inhibitors with a Unique Resistance Profile-Part 2

(2014) Florian Wakenhut et al.   ChemMedChem

The Discovery of Potent Nonstructural Protein 5A (NS5A) Inhibitors with a Unique Resistance Profile-Part 1

(2014) Thien Duc Tran et al.   ChemMedChem

Hepatitis C Virus NS5A Replication Complex Inhibitors. Part 6: Discovery of a Novel and Highly Potent Biarylimidazole Chemotype with Inhibitory Activity Toward Genotypes 1a and 1b Replicons

(2014) Makonen Belema et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery and Development of Hepatitis C Virus NS5A Replication Complex Inhibitors

(2014) Makonen Belema et al.   JOURNAL OF MEDICINAL CHEMISTRY

Hepatitis C Virus NS5A Replication Complex Inhibitors: The Discovery of Daclatasvir

(2014) Makonen Belema et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of Daclatasvir, a Pan-Genotypic Hepatitis C Virus NS5A Replication Complex Inhibitor with Potent Clinical Effect

(2014) Makonen Belema et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of ABT-267, a Pan-Genotypic Inhibitor of HCV NS5A

(2014) David A. DeGoey et al.   JOURNAL OF MEDICINAL CHEMISTRY

Enantioselective Synthesis of an HCV NS5a Antagonist

(2014) Ian K. Mangion et al.   ORGANIC LETTERS

HCV NS5A replication complex inhibitors. Part 5: Discovery of potent and pan-genotypic glycinamide cap derivatives

(2013) Makonen Belema et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Chemicals from Alkynes with Palladium Catalysts

(2013) Rafael Chinchilla et al.   CHEMICAL REVIEWS

HCV NS5A Replication Complex Inhibitors. Part 4.1 Optimization for Genotype 1a Replicon Inhibitory Activity

(2013) Denis R. St. Laurent et al.   JOURNAL OF MEDICINAL CHEMISTRY

Global control of hepatitis C: where challenge meets opportunity

(2013) David L Thomas   NATURE MEDICINE

Understanding the hepatitis C virus life cycle paves the way for highly effective therapies

(2013) Troels K H Scheel et al.   NATURE MEDICINE

Potent Hepatitis C Virus NS5A Inhibitors Containing a Benzidine Core

(2013) Il Hak Bae et al.   ACS Medicinal Chemistry Letters

HCV NS5A replication complex inhibitors. Part 3: discovery of potent analogs with distinct core topologies

(2012) Omar D. Lopez et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

A Hepatitis C Virus NS5A Phosphorylation Site That Regulates RNA Replication

(2012) K. L. LeMay et al.   JOURNAL OF VIROLOGY

C−H Bonds as Ubiquitous Functionality: A General Approach to Complex Arylated Imidazoles via Regioselective Sequential Arylation of All Three C−H Bonds and RegioselectiveN-Alkylation Enabled by SEM-Group Transposition

(2010) Jung Min Joo et al.   JOURNAL OF ORGANIC CHEMISTRY

Domain III of NS5A contributes to both RNA replication and assembly of hepatitis C virus particles

(2009) M. Hughes et al.   JOURNAL OF GENERAL VIROLOGY

Establishment of Broadly Applicable Reaction Conditions for the Palladium-Catalyzed Direct Arylation of Heteroatom-Containing Aromatic Compounds

(2009) Benoît Liégault et al.   JOURNAL OF ORGANIC CHEMISTRY

C−H Bonds as Ubiquitous Functionality: A General Approach to Complex Arylated Pyrazoles via Sequential RegioselectiveC-Arylation andN-Alkylation Enabled by SEM-Group Transposition

(2009) Roman Goikhman et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The global burden of hepatitis C

(2009) Daniel Lavanchy   LIVER INTERNATIONAL

Regioselective Synthesis of 4,5-Diaryl-1-methyl-1H-imidazoles Including Highly Cytotoxic Derivatives by Pd-Catalyzed Direct C-5 Arylation of 1-Methyl-1H-imidazole with Aryl Bromides

(2008) Fabio Bellina et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Analysis of the Concerted Metalation-Deprotonation Mechanism in Palladium-Catalyzed Direct Arylation Across a Broad Range of Aromatic Substrates

(2008) Serge I. Gorelsky et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY