Exploring the role of the α-carboxyphosphonate moiety in the HIV-RT activity of α-carboxy nucleoside phosphonates

Design and Synthesis of α-Carboxy Nucleoside Phosphonate Analogues and Evaluation as HIV-1 Reverse Transcriptase-Targeting Agents

(2015) Sarah J. Keane et al.   JOURNAL OF ORGANIC CHEMISTRY

Alpha-carboxy nucleoside phosphonates as universal nucleoside triphosphate mimics

(2015) Jan Balzarini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of HIV-1 reverse transcriptase bound to a novel 38-mer hairpin template-primer DNA aptamer

(2015) Matthew T. Miller et al.   PROTEIN SCIENCE

Modular Assembly of Purine-like Bisphosphonates as Inhibitors of HIV-1 Reverse Transcriptase

(2014) Cyrus M. Lacbay et al.   JOURNAL OF MEDICINAL CHEMISTRY

Impact of HLA-driven HIV adaptation on virulence in populations of high HIV seroprevalence

(2014) Rebecca Payne et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Temporal trends in prognostic markers of HIV-1 virulence and transmissibility: an observational cohort study

(2014) Nikos Pantazis et al.   Lancet HIV

Update on long-term treatment with bisphosphonates for postmenopausal osteoporosis: A systematic review

(2013) Erik F. Eriksen et al.   BONE

Development of O–H insertion for the attachment of phosphonates to nucleosides; synthesis of α-carboxy phosphononucleosides

(2012) Isabelle Hladezuk et al.   TETRAHEDRON

Binding modes of diketo-acid inhibitors of HIV-1 integrase: A comparative molecular dynamics simulation study

(2011) Meilan Huang et al.   JOURNAL OF MOLECULAR GRAPHICS & MODELLING

Structural and Functional Analyses of the Second-Generation Integrase Strand Transfer Inhibitor Dolutegravir (S/GSK1349572)

(2011) S. Hare et al.   MOLECULAR PHARMACOLOGY

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Design and Synthesis of α-Carboxy Phosphononucleosides

(2010) Sebastien Debarge et al.   JOURNAL OF ORGANIC CHEMISTRY

Discovery of Raltegravir, a Potent, Selective Orally Bioavailable HIV-Integrase Inhibitor for the Treatment of HIV-AIDS Infection

(2008) Vincenzo Summa et al.   JOURNAL OF MEDICINAL CHEMISTRY