Targeting anti-apoptotic Bcl2 proteins with scyllatoxin-based BH3 domain mimetics

Peptide therapeutics: Targeting the undruggable space

(2015) Natia Tsomaia   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

The Identification of Novel Protein-Protein Interactions in Liver that Affect Glucagon Receptor Activity

(2015) Junfeng Han et al.   PLoS One

Distinguishing induced fit from conformational selection

(2014) Stefano Gianni et al.   BIOPHYSICAL CHEMISTRY

Rapid screening of protein–protein interaction inhibitors using the protease exclusion assay

(2014) Saurabh R. Nirantar et al.   BIOSENSORS & BIOELECTRONICS

A Quantitative Chaperone Interaction Network Reveals the Architecture of Cellular Protein Homeostasis Pathways

(2014) Mikko Taipale et al.   CELL

Folding and Binding of an Intrinsically Disordered Protein: Fast, but Not ‘Diffusion-Limited’

(2013) Joseph M. Rogers et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

BH3 Mimetics: Status of the Field and New Developments

(2013) C. Billard   MOLECULAR CANCER THERAPEUTICS

Inhibition of α-helix-mediated protein–protein interactions using designed molecules

(2013) Valeria Azzarito et al.   Nature Chemistry

Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy

(2013) Peter E. Czabotar et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Therapeutic development in targeting protein–protein interactions with synthetic topological mimetics

(2012) Lun K Tsou et al.   CURRENT OPINION IN PHARMACOLOGY

Common and specific signatures of gene expression and protein–protein interactions in autoimmune diseases

(2012) T Tuller et al.   GENES AND IMMUNITY

Mitochondrial signaling in cell death via the Bcl-2 family

(2010) Brian Leibowitz et al.   CANCER BIOLOGY & THERAPY

Evidence that inhibition of BAX activation by BCL-2 involves its tight and preferential interaction with the BH3 domain of BAX

(2010) Bonsu Ku et al.   CELL RESEARCH

Determinants of BH3 Binding Specificity for Mcl-1 versus Bcl-xL

(2010) Sanjib Dutta et al.   JOURNAL OF MOLECULAR BIOLOGY

Profiling of Protein Interaction Networks of Protein Complexes Using Affinity Purification and Quantitative Mass Spectrometry

(2010) Robyn M. Kaake et al.   MOLECULAR & CELLULAR PROTEOMICS

The MCL-1 BH3 helix is an exclusive MCL-1 inhibitor and apoptosis sensitizer

(2010) Michelle L Stewart et al.   Nature Chemical Biology

Helix propensities of conformationally restricted amino acids. Non-natural substitutes for helix breaking proline and helix forming alanine

(2010) Miriam Alías et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Cysteine 62 of Bax Is Critical for Its Conformational Activation and Its Proapoptotic Activity in Response to H2O2-induced Apoptosis

(2008) Chunlai Nie et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeting the Human Cancer Pathway Protein Interaction Network by Structural Genomics

(2008) Yuanpeng Janet Huang et al.   MOLECULAR & CELLULAR PROTEOMICS

K2D2: Estimation of protein secondary structure from circular dichroism spectra

(2008) Carolina Perez-Iratxeta et al.   BMC STRUCTURAL BIOLOGY