An improved fluorogenic assay for SIRT1, SIRT2, and SIRT3

A mini-review on Sirtuin activity assays

(2015) Yan Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A FRET-based assay for screening SIRT5 specific modulators

(2015) Yan Li et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Sirtuins in Epigenetic Regulation

(2015) Hui Jing et al.   CHEMICAL REVIEWS

A FRET-based assay for screening SIRT6 modulators

(2015) Yan Li et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Selective Sirt2 inhibition by ligand-induced rearrangement of the active site

(2015) Tobias Rumpf et al.   Nature Communications

Efficient Demyristoylase Activity of SIRT2 Revealed by Kinetic and Structural Studies

(2015) Yan-Bin Teng et al.   Scientific Reports

Lysine Glutarylation Is a Protein Posttranslational Modification Regulated by SIRT5

(2014) Minjia Tan et al.   Cell Metabolism

New assays and approaches for discovery and design of Sirtuin modulators

(2014) Mike Schutkowski et al.   Expert Opinion on Drug Discovery

Sirtuin inhibitors as anticancer agents

(2014) Jing Hu et al.   Future Medicinal Chemistry

Mechanism of Inhibition of the Human Sirtuin Enzyme SIRT3 by Nicotinamide: Computational and Experimental Studies

(2014) Xiangying Guan et al.   PLoS One

SIRT5 Regulates the Mitochondrial Lysine Succinylome and Metabolic Networks

(2013) Matthew J. Rardin et al.   Cell Metabolism

Activation of the Protein Deacetylase SIRT6 by Long-chain Fatty Acids and Widespread Deacylation by Mammalian Sirtuins

(2013) Jessica L. Feldman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways

(2013) Jeongsoon Park et al.   MOLECULAR CELL

SIRT6 regulates TNF-α secretion through hydrolysis of long-chain fatty acyl lysine

(2013) Hong Jiang et al.   NATURE

Sorting out functions of sirtuins in cancer

(2013) M Roth et al.   ONCOGENE

A fluorogenic assay for screening Sirt6 modulators

(2013) Jing Hu et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Sirtuin activators and inhibitors

(2012) José M. Villalba et al.   BIOFACTORS

Substrates for Efficient Fluorometric Screening Employing the NAD-Dependent Sirtuin 5 Lysine Deacylase (KDAC) Enzyme

(2012) Andreas S. Madsen et al.   JOURNAL OF MEDICINAL CHEMISTRY

The many faces of insulin-like peptide signalling in the brain

(2012) Ana M. Fernandez et al.   NATURE REVIEWS NEUROSCIENCE

Sirt5 Deacylation Activities Show Differential Sensitivities to Nicotinamide Inhibition

(2012) Frank Fischer et al.   PLoS One

The discovery of novel 10,11-dihydro-5H-dibenz[b,f]azepine SIRT2 inhibitors

(2012) Paolo Di Fruscia et al.   MedChemComm

Inhibitors of the NAD+-Dependent Protein Desuccinylase and Demalonylase Sirt5

(2012) Benjamin Maurer et al.   ACS Medicinal Chemistry Letters

Sirt5 Is a NAD-Dependent Protein Lysine Demalonylase and Desuccinylase

(2011) J. Du et al.   SCIENCE

SRT1720, SRT2183, SRT1460, and Resveratrol Are Not Direct Activators of SIRT1

(2010) Michelle Pacholec et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SIRT2 inhibition achieves neuroprotection by decreasing sterol biosynthesis

(2010) Ruth Luthi-Carter et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Salermide, a Sirtuin inhibitor with a strong cancer-specific proapoptotic effect

(2008) E Lara et al.   ONCOGENE