Article
Chemistry, Multidisciplinary
Kai Hao, Lin Lin, Pingjie Sun, Yingying Hu, Maruyama Atsushi, Zhaopei Guo, Huayu Tian, Xuesi Chen
Summary: Photodynamic therapy is a novel anti-tumor therapy with excellent therapeutic effects and minimal side effects, relying on efficient loading and protection of photosensitizers. Newly designed cationic flexible organic framework nanoparticles were synthesized to inhibit aggregation and quenching of photosensitizers, demonstrating excellent gene transfection ability and antitumor effect both in vitro and in vivo. This cationic flexible organic framework material combines the advantages of flexible building units and rigid monomers, showing great potential for developing nano-photosensitizers and gene carriers for clinical application.
Article
Polymer Science
Abdechakour Elkihel, Charlotte Vernisse, Tan-Sothea Ouk, Romain Lucas-Roper, Vincent Chaleix, Vincent Sol
Summary: This study presents a synthesis method for light-triggered antibacterial hydrogels based on xylan chains chemically bound to meso-tetra(4-carboxyphenyl)porphyrin (TCPP). TCPP not only acts as an efficient photosensitizer against Gram-positive bacteria, but also serves as a cross-linking agent for the hydrogels. The hydrogels were characterized using infrared spectroscopy (ATR-FTIR), scanning electron microscopy (SEM), and swelling and rheological tests. Under visible light irradiation, the hydrogels showed interesting antimicrobial activity against Staphylococcus aureus and Bacillus cereus, suggesting their potential for the treatment of skin bacterial infections through photodynamic antimicrobial chemotherapy (PACT).
Article
Chemistry, Physical
Ewelina Musielak, Agnieszka Feliczak-Guzik, Mietek Jaroniec, Izabela Nowak
Summary: Photodynamic therapy (PDT) is a promising alternative to traditional active substance release methods, utilizing photosensitizers and specific energy radiation. Curcumin, a natural photosensitizer, has anti-inflammatory, antioxidant, and anti-cancer effects. However, the solubility of curcumin in water limits its clinical application in PDT. Using hierarchical zeolites as carriers is a potential strategy to overcome this difficulty.
Article
Materials Science, Multidisciplinary
Monisha Manathanath, Benu George, Juraij Kandiyil, Subramaniam Sujatha, Suchithra Tharamel Vasu, Sujith Athiyanathil, Unnikrishnan Gopalakrishna Panicker
Summary: This study explores a method that combines a biodegradable polymer scaffold with a photosensitizer for antibacterial photodynamic therapy. The results show a high inhibition rate against E. coli and S. aureus using this method.
MATERIALS TODAY COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Nuno M. M. Moura, Xavier Moreira, Eliana Sousa Da Silva, Joaquim Luis Faria, Maria G. P. M. S. Neves, Adelaide Almeida, Maria A. F. Faustino, Ana T. P. C. Gomes
Summary: Antimicrobial photodynamic therapy is a promising and innovative approach for the photoinactivation of microorganisms. This study demonstrates the excellent performance of porphyrin derivatives incorporated into materials for efficient photodynamic effect. These materials showed high efficacy in photoinactivating methicillin-resistant Staphylococcus aureus.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Physical
Dong Wang, Zhihao Fan, Haofeng Min, Xinhao Wang, Hui Li, Jiqian Wang
Summary: Delivery of antitumor drugs to tumor cells by targeted lipopeptide carriers, which can be specifically degraded by MMP-7, enables targeted release of hydrophobic drugs and improves chemotherapy efficiency. Different encapsulation and release behaviors are observed due to the different hydrophobicity of lipopeptides and antitumor drugs. This study demonstrates the biocompatibility and low toxicity of enzyme-sensitive targeting lipopeptides, indicating their potential in efficient drug delivery for biomedical oncology therapy. (c) 2023 Elsevier B.V. All rights reserved.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Chemistry, Applied
Stylianos Panagiotakis, Barbara Mavroidi, Alexandros Athanasopoulos, Antonio Ricardo Goncalves, Loic Bugnicourt-Moreira, Theo Regagnon, Nikos Boukos, George Charalambidis, Athanasios G. Coutsolelos, Mantas Grigalavicius, Theodossis A. Theodossiou, Kristian Berg, Catherine Ladaviere, Maria Pelecanou, Konstantina Yannakopoulou
Summary: In order to target cancer cell lysosomes for drug transport and light-controlled release, we synthesized new conjugates of beta-cyclodextrin with highly hydrophobic triphenylporphyrin. These conjugates self-assemble into similar nanoparticles in water and selectively target the lysosomes of breast adenocarcinoma cells. The nanoparticles exhibit photoactivity and can bind with different anticancer drugs.
CARBOHYDRATE POLYMERS
(2023)
Review
Chemistry, Multidisciplinary
Jong Min Park, Kyeong-Im Hong, Hosoowi Lee, Woo-Dong Jang
Summary: Porphyrin derivatives play important roles in biological processes such as photosynthesis, oxygen transport, and catalysis, exhibiting versatile functionality through noncovalent interactions with proteins. They are excellent host compounds and key components in functional supramolecular assemblies due to their symmetrical molecular architecture and excellent photophysical properties. Their applications in bioactive functional materials and biomedical nanodevice fabrication are promising despite limitations such as aggregation in aqueous media.
ACCOUNTS OF CHEMICAL RESEARCH
(2021)
Article
Engineering, Biomedical
Yang Yang, Kaiqi Long, Yiqun Wang, Lei Li, Jiayue Shi, Jican Liu, Lingxi Kong, Lin Yu, Jiandong Ding, Zhili Huang, Weiping Wang, Changyou Zhan
Summary: This study introduces a technique for drug release triggered by near infrared light, achieving quantitative pulsed drug release by loading photocleavable prodrugs into hydrogels. This system demonstrates characteristics of good stability, visible drug release process, and efficient light responsiveness.
ADVANCED HEALTHCARE MATERIALS
(2022)
Review
Biotechnology & Applied Microbiology
Runcong Liu, Yongjun Peng, Ligong Lu, Shaojun Peng, Tianfeng Chen, Meixiao Zhan
Summary: Gas therapy as a new cancer treatment method has gained increasing attention in recent years. By using near-infrared light as a stimulus to trigger the release of gas molecules, it has achieved improved therapeutic efficacy and reduced side effects.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Haiqin Song, Zhenghao Cai, Juyi Li, Haihua Xiao, Ruogu Qi, Minhua Zheng
Summary: Photodynamic therapy combined with chemotherapy and immunotherapy using a triple action cationic porphyrin-cisplatin conjugate showed promising results in this study. The nanoparticles delivered the drugs and generated reactive oxygen species for treatment, while triggering immunogenic cell death cascade. This novel approach has great potential in cancer treatment.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Enling Chang, Jiachuan Bu, Lili Ding, Jenny W. H. Lou, Michael S. Valic, Miffy. H. Y. Cheng, Veronique Rosilio, Juan Chen, Gang Zheng
Summary: The PLNE-PTX nanoemulsion, utilizing porphyrin-lipids, effectively combines PDT and chemotherapy, demonstrating superior anti-tumor effects and potential to reduce side effects associated with monotherapy chemotherapy. Its inherent imaging modality enables real-time tracking and spatial and temporal regulation to improve cancer treatment.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Article
Materials Science, Multidisciplinary
Tarik Rust, Dimitri Jung, Axel Hoppe, Timo Schoppa, Klaus Langer, Dirk Kuckling
Summary: The study synthesized a series of light-responsive polymers that can degrade rapidly in solution, enabling precise drug release and improved therapeutic effects.
ACS APPLIED POLYMER MATERIALS
(2021)
Article
Biophysics
Marcos E. Peralta, Julieta C. Parisi, Daniel C. Castrogiovanni, Sushilkumar A. Jadhav, Luciano Carlos, Gabriela N. Bosio, Daniel O. Martire
Summary: Stimuli-responsive nanocarriers have significant applications in the development of new strategies for disease diagnosis and treatment. This study demonstrates the controlled drug delivery using magnetite nanoparticles coated with mesoporous silica and grafted with a thermoresponsive polymer. The efficient drug release and the cytoprotective effect of a specific drug were evaluated using various cell models, providing potential applications for this drug delivery system.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Chemistry, Multidisciplinary
Kaiqi Long, Yang Yang, Wen Lv, Kuan Jiang, Yafei Li, Amy Cheuk Yin Lo, Wai Ching Lam, Changyou Zhan, Weiping Wang
Summary: Retinoblastoma is a severe ocular disease that is typically treated with repetitive intravitreal injections of chemotherapeutics. However, a new study has introduced a photoresponsive drug release system that can potentially enhance drug accumulation in the eye through light-triggered intravenous injections of drug-loaded nanocarriers. This proof-of-concept study may pave the way for the development of improved treatment options for eye diseases using light-triggered drug release systems.
Article
Biochemistry & Molecular Biology
Sharareh Houshmandyar, Ian M. Eggleston, Albert Bolhuis
Summary: The study found that the chelators DFP and CP94 have different effects on P. aeruginosa in planktonic cells and biofilms, with CP94 stimulating biofilm formation. CP94 was hypothesized to act as an iron carrier, and it exhibited antimicrobial synergy with toxic metals gallium and copper.
Article
Multidisciplinary Sciences
Kurinchi S. Gurusamy, David Moher, Marilena Loizidou, Irfan Ahmed, Marc T. Avey, Carly C. Barron, Brian Davidson, Miriam Dwek, Christian Gluud, Gavin Jell, Kiran Katakam, Joshua Montroy, Timothy D. McHugh, Nicola J. Osborne, Merel Ritskes-Hoitinga, Kees van Laarhoven, Jan Vollert, Manoj Lalu
Summary: The study developed a tool to assess the clinical relevance of preclinical studies and refined and developed it using a modified Delphi consensus. The tool consists of eight domains and 28 signaling questions, providing a framework for researchers, journal editors, grant funders, and regulatory authorities to assess the potential clinical relevance of preclinical animal research.
Review
Biochemistry & Molecular Biology
Paolo Dognini, Christopher R. Coxon, Wendel A. Alves, Francesca Giuntini
Summary: The covalent and noncovalent association of self-assembling peptides and tetrapyrroles can generate systems that mimic Nature's functional supramolecular structures, enhancing the photochemical properties of embedded chromophores and enabling various applications.
Article
Biochemistry & Molecular Biology
Judith Pape, Katerina Stamati, Rawiya Al Hosni, Ijeoma F. Uchegbu, Andreas G. Schatzlein, Marilena Loizidou, Mark Emberton, Umber Cheema
Summary: The study utilized a biomimetic model including artificial cancer mass and fibrotic stromal compartment to mimic pancreatic cancer. The results showed varying drug sensitivity across different tumor models, with significantly reduced drug penetration in the complex tumor model.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Federica Foglietta, Vanessa Pinnelli, Francesca Giuntini, Nadia Barbero, Patrizia Panzanelli, Gianni Durando, Enzo Terreno, Loredana Serpe, Roberto Canaparo
Summary: The study aims to evaluate whether the new anticancer approach SDT can selectively target cancer cells while sparing normal cells. Results show that SDT has different effects on cancer cells and normal cells, indicating a potential for treatment selectivity.
Article
Construction & Building Technology
Hazha Mohammed, Francesca Giuntini, Monower Sadique, Andy Shaw, Ana Bras
Summary: This research analyzes the influence of polymers on the mechanical and durability properties of concrete. The results show that polymer modified concrete is suitable for heavily reinforced sections with vibration. Adding polymer granules and powder can increase the strength of the concrete, and the effect of preventing water migration generally occurs 2-3 days after the concrete is exposed to water.
CONSTRUCTION AND BUILDING MATERIALS
(2022)
Article
Chemistry, Inorganic & Nuclear
Mahshid Hashemkhani, Marilena Loizidou, Alexander J. MacRobert, Hawa Yagci Acar
Summary: This study demonstrated the one-step aqueous synthesis of simple AgInS2 QD compositions for the first time. The potential of these AIS QDs as effective drug carriers and in photodynamic therapy was proven through evaluation.
INORGANIC CHEMISTRY
(2022)
Article
Materials Science, Biomaterials
Jose Eduardo Ulloa Rojas, Vivian Leite de Oliveira, Daniele Ribeiro de Araujo, Giovana Radomille Tofoli, Matheus Mendes de Oliveira, Danilo Justino Carastan, Moises Palaci, Francesca Giuntini, Wendel Andrade Alves
Summary: This study proposes the use of polymeric microneedles to improve the skin penetration of photosensitizers in photodynamic therapy. The microneedle arrays made of silk fibroin and poly(vinyl alcohol) showed good mechanical strength and depth of insertion in both synthetic and animal skins. The results demonstrate increased permeation of porphyrin through porcine skin treated with the polymer microneedles.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2022)
Article
Chemistry, Medicinal
Jean-Jacques Helesbeux, Laura Carro, Florence O. McCarthy, Vania M. Moreira, Francesca Giuntini, Niamh O'Boyle, Susan E. Matthews, Guelsah Bayraktar, Samuel Bertrand, Christophe Rochais, Pascal Marchand
Summary: The 29th Annual GP(2)A Conference was held virtually this year due to the COVID-19 pandemic, spanning three days and attracting an international delegation of researchers. Keynote lectures, young researcher talks, and flash presentation posters were included in the report, showcasing high-level scientific discussions on cutting-edge advances in pharmaceutical chemistry.
Review
Oncology
Jeries Abu-Hanna, Jigisha A. Patel, Evangelos Anastasakis, Richard Cohen, Lucie H. Clapp, Marilena Loizidou, Mohammad M. R. Eddama
Summary: This review examines and summarizes the therapeutic potential of inhibiting H3K27 demethylases, with a focus on the small-molecule inhibitor GSK-J4, based on pre-clinical in vitro and in vivo evidence.
CLINICAL EPIGENETICS
(2022)
Article
Biochemistry & Molecular Biology
Layla Mohammad Hadi, Katerina Stamati, Elnaz Yaghini, Alexander J. MacRobert, Marilena Loizidou
Summary: Photochemical internalisation (PCI) is a method that uses sub-lethal photodynamic therapy (PDT) to control cytosolic drug delivery, activating a photosensitiser with non-ionising visible light. This study examines the efficacy of PCI on ovarian cancer tumouroids using a porphyrin photosensitiser and a cytotoxin (Saporin), showing that PCI effectively decreases cancer cell viability within the central cancer mass and the surrounding stroma. Compared to treatment with Saporin or PDT alone, PCI significantly reduces stromal invasion by cancer cells. Tumouroids are suitable models for studying multi-cellular events after pharmacological assault.
Article
Chemistry, Multidisciplinary
Paolo Dognini, Talhat Chaudhry, Giulia Scagnetti, Michele Assante, George S. M. Hanson, Kehinde Ross, Francesca Giuntini, Christopher R. Coxon
Summary: This study presents a method for peptide cyclisation using polyfluorinated aromatic reagents and thiolates through nucleophilic aromatic substitution (SNAr). The resulting peptide scaffolds offer new possibilities for 3D peptide architectures. The method demonstrates chemoselectivity and wide applicability, allowing for stapling and multicyclisation of non-protected peptides. Additionally, a porphyrin-templated stapled peptide with skin cell penetrating ability and intrinsic fluorescence was developed.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Meeting Abstract
Surgery
Mohammad Eddama, Rijan Gurung, Konstantinos Fragkos, Richard Cohen, Marilena Loizidou, Lucie Clapp
BRITISH JOURNAL OF SURGERY
(2022)
Meeting Abstract
Oncology
U. Cheema, J. Pape, D. Bakkalci, M. Loizidou, K. Stamati, M. Emberton, S. Fedele
JOURNAL OF PATHOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Roberto Canaparo, Federica Foglietta, Francesca Giuntini, Andrea Francovich, Loredana Serpe
PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES
(2020)
Article
Chemistry, Organic
Faiza Diaba, Gisela Trenchs
Summary: The first violet light-mediated synthesis of gamma- and delta-lactams from N-alkenyl trichloroacetamides is reported in this paper. The reactions are conducted in tetrahydrofuran or 2-methyltetrahydrofuran as the sole solvent without catalysts or additives, under non-anhydrous conditions in an air atmosphere where the solvent serves as the radical initiator.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Article
Chemistry, Organic
Feroze Hussain, Sajjad Ahmed, Ashiq Hussain Padder, Qazi Naveed Ahmed
Summary: This study reports a novel and efficient one-pot synthesis method for mixed phosphorotrithioates, which does not require supplementary additives and shows broad applicability.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Article
Chemistry, Organic
Hyunjin Oh, Ikyon Kim
Summary: A new 1,2,4-triazole-pyrrolo[1,2-a]pyrazine hybrid system, 6-acylpyrrolo[1,2-a][1,2,4]triazolo[5,1-c]pyrazine, was synthesized using a catalyst-free method. This method involved sequential exposure of pyrrole-2-carbonitrile-derived substrates to DMF-DMA and acyl hydrazide, resulting in the formation of acylated pyrazine and 1,2,4-triazole rings, enabling the installation of various substituents at specific positions on the core skeleton.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Article
Chemistry, Organic
Ming Yan, Si-fan Wang, Yong-po Zhang, Jin-zhong Zhao, Zhuo Tang, Guang-xun Li
Summary: Here we developed an efficient photocatalytic approach for the convenient preparation of sulfinamides. The reaction allows for the gram-scale preparation of sulfinamides and the one-pot synthesis of various sulfonyl amides.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Article
Chemistry, Organic
Farzaneh Bandehali-Naeini, Zahra Tanbakouchian, Noushin Farajinia-Lehi, Nicolas Mayer, Morteza Shiri, Martin Breugst
Summary: Two tandem catalytic systems were developed for the synthesis of novel 3,4-disubstituted maleimides using the same Ugi adducts. Different maleimide structures can be synthesized using either Pd or Cu catalysis.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Article
Chemistry, Organic
Tanya Raghava, Anjan Chattopadhyay, Subhadeep Banerjee, Nivedita Sarkar
Summary: Amine substitution of two ortho fluorine atoms of tetrafluoroterephthalonitrile through SNAr chemistry is easily achievable. But further fluorine substitution is only possible under forcing conditions, yielding valuable fluorophores for bioimaging.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Review
Chemistry, Organic
Anju Chadha, Santosh Kumar Padhi, Selvaraj Stella, Sowmyalakshmi Venkataraman, Thangavelu Saravanan
Summary: Alcohol dehydrogenases are enzymes that use cofactors for oxidation or reduction reactions of alcohols or carbonyl compounds. They are utilized in green chemistry and have applications in the production of pharmaceuticals. Recombinant enzymes have solved the challenge of producing purified enzymes in large quantities. Engineered alcohol dehydrogenases have been used in asymmetric synthesis in industry. Various methods have been established for regenerating expensive cofactors to make the enzymatic process more efficient and economically viable.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
