Journal
ORAL ONCOLOGY
Volume 57, Issue -, Pages 32-39Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.oraloncology.2016.04.007
Keywords
Image guided surgery; Near infrared fluorescence; Fluorescence molecular imaging; Sentinel lymph node; Head and neck neoplasm; Squamous cell carcinoma
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Complete resection of head and neck tumors relies on palpation and visual inspection. Achieving a negative margin in remote locations in the head and neck region, especially in close proximity to critical structures, is often difficult to achieve. Positive resection margins in head and neck cancer are at high risk to develop recurrent disease and associated with poor prognosis. Near-infrared fluorescence-guided optical imaging is an emerging technology with the potential to move the surgical field forward and facilitate surgeons to visualize tumors in real-time intra-operatively. In this review, our focus is to discuss the recent advances and the potential application of near infrared (NIR) fluorescent-guided surgery in the management of head and neck cancer. (C) 2016 Elsevier Ltd. All rights reserved.
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