4.6 Article

INHIBIT-Inspired Two-Output DNA Logic Gates Based on Surface-Enhanced Raman Scattering

Journal

CHEMISTRY-A EUROPEAN JOURNAL
Volume 21, Issue 41, Pages 14301-14304

Publisher

WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201502938

Keywords

analytical methods; DNA; half-adder; logic gates; surface-enhanced Raman scattering

Funding

  1. Natural Science Foundation of China (NSFC) [20927003, 90913013, 41273093, 21175101]

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Herein, we presented a novel logic gate based on an INHIBITION gate that performs parallel readouts. Logic gates performing INHIBITION and YES/OR were constructed using surface-enhanced Raman scattering as optical outputs for the first time. The strategy allowed for simultaneous reading of outputs in one tube. The applicability of this strategy has been successfully exemplified in the construction of half-adder using the two-output logic gates as reporting gates. This reporting strategy provides additional design flexibility for dynamic DNA devices.

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