Journal
ORAL ONCOLOGY
Volume 61, Issue -, Pages 152-158Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.oraloncology.2016.08.001
Keywords
PD-1; PD-L1; PD-L2; B7-H1; Immune checkpoint; Squamous cell carcinoma; Head and neck cancer; Immunotherapy
Categories
Funding
- NIH/NIDCR [1R01DE025340-01]
Ask authors/readers for more resources
We review the current clinical knowledge surrounding one of the most promising immune checkpoint pathways currently investigated in head and neck squamous cell carcinoma patients, programmed cell death-1 (PD-1) and its ligands (PD-L1 and PD-L2). We review ongoing clinical trials and associated clinical responses observed with targeting the receptor, PD-1, and its ligand, PD-L1. A recent phase III clinical trial (Checkmate 141) demonstrated an improved overall survival in head and neck cancer patients treated with anti-PD-1 monotherapy as compared to standard of care for recurrent and/or metastatic disease, which raises questions on how best to incorporate immunotherapy in the context of standard of care. We discuss biomarkers of response to this class of novel drugs, which is an area of active investigation. Lastly, we project future directions in the field wherein understanding how the Fc portions of the various monoclonal antibodies may impact their clinical efficacy as well as discuss areas where our next advances may take place, such as combination strategies. (C) 2016 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available