Effects of neratinib and combination with irradiation and chemotherapy in head and neck cancer cells

Increased Expression of HER2, HER3, and HER2:HER3 Heterodimers in HPV-Positive HNSCC Using a Novel Proximity-Based Assay: Implications for Targeted Therapies

(2015) N. I. Pollock et al.   CLINICAL CANCER RESEARCH

Irreversible Multitargeted ErbB Family Inhibitors for Therapy of Lung and Breast Cancer

(2015) Deepa Subramaniam et al.   CURRENT CANCER DRUG TARGETS

Molecular profiling of head and neck squamous cell carcinoma

(2015) Rebecca Feldman et al.   HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK

Afatinib versus methotrexate as second-line treatment in patients with recurrent or metastatic squamous-cell carcinoma of the head and neck progressing on or after platinum-based therapy (LUX-Head & Neck 1): an open-label, randomised phase 3 trial

(2015) Jean-Pascal H Machiels et al.   LANCET ONCOLOGY

Combined TP53 mutation/3p loss correlates with decreased radiosensitivity and increased matrix-metalloproteinase activity in head and neck carcinoma

(2015) Sharat C. Raju et al.   ORAL ONCOLOGY

Cytotoxic effect of lapatinib is restricted to human papillomavirus-positive head and neck squamous cell carcinoma cell lines

(2015) Ingrid Fumagalli et al.   OncoTargets and Therapy

A randomized, phase II study of afatinib versus cetuximab in metastatic or recurrent squamous cell carcinoma of the head and neck†

(2014) T. Y. Seiwert et al.   ANNALS OF ONCOLOGY

Neratinib shows efficacy in the treatment of HER2/neu amplified uterine serous carcinoma in vitro and in vivo

(2014) Carlton L. Schwab et al.   GYNECOLOGIC ONCOLOGY

Safety and Efficacy of Neratinib in Combination With Capecitabine in Patients With Metastatic Human Epidermal Growth Factor Receptor 2–Positive Breast Cancer

(2014) Cristina Saura et al.   JOURNAL OF CLINICAL ONCOLOGY

Cardiotoxicity of novel HER2-targeted therapies

(2013) Mehmet A.N. Sendur et al.   CURRENT MEDICAL RESEARCH AND OPINION

A phase two randomised trial of neratinib monotherapy versus lapatinib plus capecitabine combination therapy in patients with HER2+ advanced breast cancer

(2013) Miguel Martin et al.   EUROPEAN JOURNAL OF CANCER

Preclinical and clinical development of afatinib: a focus on breast cancer and squamous cell carcinoma of the head and neck

(2013) Nadia Harbeck et al.   Future Oncology

Phase I Study of Neratinib in Combination With Temsirolimus in Patients With Human Epidermal Growth Factor Receptor 2–Dependent and Other Solid Tumors

(2013) Leena Gandhi et al.   JOURNAL OF CLINICAL ONCOLOGY

Her2 activation mechanism reflects evolutionary preservation of asymmetric ectodomain dimers in the human EGFR family

(2013) Anton Arkhipov et al.   eLife

Dual Kinase Inhibition of EGFR and HER2 Overcomes Resistance to Cetuximab in a NovelIn VivoModel of Acquired Cetuximab Resistance

(2011) Kelly M. Quesnelle et al.   CLINICAL CANCER RESEARCH

Membranous expression of Her3 is associated with a decreased survival in head and neck squamous cell carcinoma

(2011) Mikiko Takikita et al.   Journal of Translational Medicine

A Single-Dose, Crossover, Placebo- and Moxifloxacin-Controlled Study to Assess the Effects of Neratinib (HKI-272) on Cardiac Repolarization in Healthy Adult Subjects

(2010) B. Hug et al.   CLINICAL CANCER RESEARCH

Changes in Survival in Head and Neck Cancers in the Late 20th and Early 21st Century: A Period Analysis

(2010) D. Pulte et al.   ONCOLOGIST

7β-Hydroxycholesterol Induces Apoptosis and Regulates Cyclooxygenase 2 in Head and Neck Squamous Cell Carcinoma

(2009) Gregor Heiduschka et al.   ARCHIVES OF OTOLARYNGOLOGY-HEAD & NECK SURGERY

HER2 Expression Predicts Improved Survival in Patients with Cervical Node-Positive Head and Neck Squamous Cell Carcinoma

(2009) Gary M. Tse et al.   OTOLARYNGOLOGY-HEAD AND NECK SURGERY

Mechanisms of acquired resistance to cetuximab: role of HER (ErbB) family members

(2008) D L Wheeler et al.   ONCOGENE

The extreme radiosensitivity of the squamous cell carcinoma SKX is due to a defect in double-strand break repair

(2008) Ulla Kasten-Pisula et al.   RADIOTHERAPY AND ONCOLOGY