Article
Medicine, General & Internal
Hui Xiao, Yimin Zhong, Yunlan Ling, Xiaoyu Xu, Xing Liu
Summary: This study investigated the differences in longitudinal changes in the peripapillary retinal nerve fiber layer and macular ganglion cell plus inner plexiform layer caused by progressive myopia and glaucoma among adolescents. The results showed that the patterns of loss were different between the two groups, and certain indicators could help distinguish between glaucoma and myopia.
FRONTIERS IN MEDICINE
(2022)
Article
Biology
Mael Lever, Christian Halfwassen, Jan Darius Unterlauft, Nikolaos E. Bechrakis, Anke Manthey, Michael R. R. Bohm
Summary: Optical coherence tomography (OCT) is a valuable tool for diagnosing pediatric glaucoma by quantifying thickness reduction in the peripapillary retinal nerve fiber layer (pRNFL) and macula. Studies have shown a correlation between reduced pRNFL and inner macular layer thickness and the presence of glaucoma in children. Combining pRNFL sectors or inner macular layers can enhance the diagnostic ability, although sensitivity may vary.
Article
Medicine, General & Internal
Yali Wu, Qing Cun, Yijin Tao, Wenyan Yang, Jia Wei, Daoqing Fan, Ying Zhang, Qin Chen, Hua Zhong
Summary: The study showed that estimated retinal ganglion cells play a significant role in the diagnosis and staging of glaucoma, with the estimates gradually decreasing as glaucoma progresses.
FRONTIERS IN MEDICINE
(2021)
Article
Ophthalmology
Alessandro Rabiolo, Federico Fantaguzzi, Giovanni Montesano, Maria Brambati, Riccardo Sacconi, Francesco Gelormini, Giacinto Triolo, Paolo Bettin, Giuseppe Querques, Francesco Bandello
Summary: This study compared the measurements of pRNFL and mGCIPL thickness obtained with SD-OCT and SS-OCT, and assessed their ability to distinguish among glaucoma patients, glaucoma suspects, and healthy controls. The results showed that both SD-OCT and SS-OCT detected thinning in pRNFL and mGCIPL in glaucoma patients compared to healthy controls and glaucoma suspects. The two devices demonstrated similar diagnostic abilities, and conversion formulas could be used to remove the proportional bias.
TRANSLATIONAL VISION SCIENCE & TECHNOLOGY
(2022)
Article
Ophthalmology
Clarice Kai-Ying Su, Philip Yawen Guo, Poemen Pui Man Chan, Alexander Ka-Ngai Lam, Christopher Kai Shun Leung
Summary: The purpose of this study was to investigate the prevalence, patterns, and risk factors of retinal nerve fiber layer (RNFL) defects in patients with ocular hypertension (OHT). The study found that a considerable proportion of OHT patients exhibited RNFL defects, which may represent an early sign of glaucoma. Age, visual field pattern standard deviation, cup volume, and the OHTS-EPGS risk score were associated with RNFL defects.
Review
Behavioral Sciences
Arshad Mehmood, Wajid Ali, Shuang Song, Zaheer Ud Din, Ruo-Yi Guo, Wahid Shah, Ikram Ilahi, Bowen Yin, Hongjing Yan, Lu Zhang, Murad Khan, Wajid Ali, Liaqat Zeb, Hamidreza Safari, Bin Li
Summary: The study demonstrates the potential of optical coherence tomography (OCT) in monitoring and diagnosing multiple sclerosis (MS) by showing changes in retinal structures that reflect the progression of the disease. OCT parameters serve as noninvasive and sensitive indicators for assessing neurodegeneration and inflammation in MS.
BRAIN AND BEHAVIOR
(2021)
Article
Biochemistry & Molecular Biology
Malgorzata Wichrowska, Slawomir Liberski, Anna Rzeszotarska, Przemyslaw Wichrowski, Jaroslaw Kociecki
Summary: This study aimed to characterize the thickness of the retinal nerve fiber layer (RNFL) and ganglion cell layer (GCL) in eyes affected by wet age-related macular degeneration (wAMD) treated with anti-VEGF, and compare it with the control group of eyes affected by early stages of dry age-related macular degeneration (dAMD). The study found that the GCL was thinner in the wAMD group compared to the dAMD group, while there were no significant differences in RNFL thickness. The number of injections received was found to have a significant correlation with layer thickness, and age over 73 was identified as a significant factor affecting RNFL thickness in both groups.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Alberto Dominguez-Vicent, Maria Nilsson, Rune Brautaset, Abinaya Priya Venkataraman
Summary: This study evaluated the similarities between horizontal and vertical Optical Coherence Tomography (OCT) scans in measuring individual retinal layer thickness. The results showed that the differences in thickness measurements between the two scans were smaller than the instrument's resolution in all groups. The differences in measurements varied among different layers and sectors, suggesting the importance of consistent scan direction in follow-up OCT measurements and clinical studies.
SCIENTIFIC REPORTS
(2022)
Article
Ophthalmology
Maya Yamane, Henry Ferreyra, Benjamin Y. Xu, Robert N. Weinreb, Andrew S. Camp
Summary: Ganglion cell analysis (GCA) is routinely used to monitor glaucomatous damage, but a full macular cube scan provides more information about nonglaucomatous ocular pathology.
JAMA OPHTHALMOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Alifia Revan Prananda, Eka Legya Frannita, Augustine Herini Tita Hutami, Muhammad Rifqi Maarif, Norma Latif Fitriyani, Muhammad Syafrudin
Summary: Recently, the development of a rapid detection approach using artificial intelligence for detecting glaucoma disease has been proposed. Cup-to-disc ratio (CDR) and disc damage likelihood scale (DDLS) are commonly used for glaucoma analysis, but their variability in individuals makes it difficult. To solve this problem, a new method of glaucoma detection based on analyzing the damage to the retinal nerve fiber layer (RNFL) is proposed, with a pre-treatment process and a glaucoma classification process. With the use of nine deep-learning architectures, the proposed method achieves a highest accuracy of 92.88% and an AUC of 89.34% in the evaluation using the ORIGA dataset, showing improved results compared to previous research works. The model is expected to contribute to the improvement of eye disease diagnosis and assessment.
APPLIED SCIENCES-BASEL
(2023)
Article
Multidisciplinary Sciences
Rebecca A. Cox, Scott A. Read, Shelley Hopkins, David Alonso-Caneiro, Joanne M. Wood
Summary: Significant differences were found in macular retinal thickness between Australian Aboriginal and/or Torres Strait Islander children and non-Indigenous children, which has implications for interpreting optical coherence tomography data and evaluating the risk of macula disease in this population.
Article
Neuroimaging
Jacqueline Chua, Mihai Bostan, Chi Li, Yin Ci Sim, Inna Bujor, Damon Wong, Bingyao Tan, Xinwen Yao, Florian Schwarzhans, Gerhard Garhoefer, Georg Fischer, Clemens Vass, Cristina Tiu, Ruxandra Pirvulescu, Alina Popa-Cherecheanu, Leopold Schmetterer
Summary: This study improves the capability of OCT in differentiating non-optic neuritis eyes of relapsing-remitting MS patients from healthy controls by compensating for peripapillary retinal nerve fiber layer thickness and combining with macular layers. The results show that compensated pRNFL achieved better performance than measured pRNFL for MS differentiation, and combining macular and compensated pRNFL parameters provided the best discrimination of MS, with an average improvement in sensitivity of 24 percent for differentiation of MS individuals.
NEUROIMAGE-CLINICAL
(2022)
Article
Environmental Sciences
Laure Gayraud, Marion Mortamais, Cedric Schweitzer, Kees de Hoogh, Audrey Cougnard-Gregoire, Jean-Francois Korobelnik, Marie-Noelle Delyfer, Marie-Benedicte Rougier, Karen Leffondre, Catherine Helmer, Danielle Vienneau, Claudine Berr, Cecile Delcourt
Summary: Chronic exposure to air pollution, particularly fine particulate matter (PM2.5) and black carbon (BC), is associated with faster thinning of the retinal nerve fiber layer (RNFL) in individuals with glaucoma. This study highlights the importance of considering air pollution as a potential risk factor for neurodegenerative diseases.
ENVIRONMENTAL RESEARCH
(2023)
Article
Ophthalmology
Christopher Bowd, Akram Belghith, Jasmin Rezapour, Mark Christopher, Leslie Hyman, Jost B. Jonas, Robert N. Weinreb, Linda M. Zangwill
Summary: This study evaluated the diagnostic accuracy of a novel optical coherence tomography texture-based en face image analysis (SALSA-Texture) for glaucoma detection in eyes with high myopia, and compared it with standard macular parameters. The results showed that the texture-based analysis method performed better in discriminating between glaucomatous and healthy eyes with high myopia compared to traditional retinal layer segmentation.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Multidisciplinary Sciences
Ai Ping Yow, Jacqueline Chua, Bingyao Tan, Rachel Chong, Monisha E. Nongpiur, Preeti Gupta, Ecosse Lamoureux, Rahat Husain, Leopold Schmetterer, Damon Wong
Summary: This study used OCT and OCT angiography to evaluate the contributions of the neuronal and vascular components to the detection of glaucoma and modeling of visual field loss in the RNFL. The neuronal component alone improved glaucoma detection, and combining it with the capillary component further improved detection. These findings can enhance our understanding of the disease and its management.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2023)
Article
Ophthalmology
Fabrizio Gaetano Saverio Franco, Cristina Nicolosi, Giulio Vicini, Piero Grasso Cannizzo, Gianni Virgili, Fabrizio Giansanti
Summary: This study demonstrates the successful correction of complex spherical-cylindrical refractive defects in a case of abnormal cornea and cataract using a combination of primary and piggyback IOL implantation.
EUROPEAN JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Giulia Coco, Hannah J. Levis, Alfredo Borgia, Davide Romano, Luca Pagano, Gianni Virgili, Stephen B. Kaye, Vito Romano
Summary: By evaluating the features of anterior segment optical coherence tomography (AS-OCT), it was found that posterior stromal ripples and detachment axial extension are the main risk factors for graft detachment worsening in Descemet's membrane endothelial keratoplasty (DMEK). Patients showing these features should be closely monitored to identify the need for re-bubbling at an early stage, thus improving surgical outcomes.
ACTA OPHTHALMOLOGICA
(2023)
Review
Ophthalmology
Sara Lucchini, Andrea Govetto, Elisa Carini, Giuseppe Casalino, Simone Donati, Paolo Radice
Summary: We report a case of presumed sympathetic ophthalmia following scleral buckling surgery and review the current evidence on its pathogenesis. Multimodal imaging techniques were used for diagnosis and treatment, and good long-term clinical outcomes were achieved.
EUROPEAN JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Antonio Fea, Matteo Sacchi, Fabrizio Franco, Gian Luca Laffi, Francesco Oddone, Giacomo Costa, Federica Serino, Fabrizio Giansanti
Summary: The XEN45 implant was found to be effective and safe in treating primary open angle glaucoma (OAG) eyes with high myopia. While the rate of hypotony was relatively high, it was resolved within a short period of time with medical therapy.
JOURNAL OF GLAUCOMA
(2023)
Review
Pharmacology & Pharmacy
Grazia R. Tundo, Paolo Cascio, Danilo Milardi, Anna Maria Santoro, Grazia Graziani, Pedro Miguel Lacal, Alessio Bocedi, Francesco Oddone, Mariacristina Parravano, Andrea Coletta, Massimo Coletta, Diego Sbardella
Summary: The immunoproteasome, initially discovered for its role in MHC class I antigen processing and immune system modulation, has been found to have additional functions unrelated to antigen presentation. Its expression and activity alterations are important in understanding neuroinflammation dynamics and the pathogenesis of neurological disorders. Furthermore, these new functions suggest the potential of immunoproteasome as a therapeutic target for neurodegeneration. This review provides an overview of the structure-function relationships of immunoproteasome and its observed neuro-modulatory functions.
PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Medicine, General & Internal
Brent Siesky, Alon Harris, Alice Verticchio Vercellin, Julia Arciero, Brendan Fry, George Eckert, Giovanna Guidoboni, Francesco Oddone, Gal Antman
Summary: This study examined the differences in ocular hemodynamic biomarkers between early open angle glaucoma (OAG) patients and healthy controls of African and European descent. The results showed that vascular densities were significantly lower in European OAG patients, while central macular vascular density was lower in African OAG patients. Macular and parafoveal thickness were also significantly lower in African OAG patients compared to European patients. Additionally, there was a negative correlation between intraocular pressure (IOP) and visual field index in African OAG patients, while a slightly positive relationship was observed in European patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Ophthalmology
A. N. D. R. E. A. Spini, S. A. B. R. I. N. A. Giometto, S. A. N. D. R. A. Donnini, M. A. T. T. E. O. Posarelli, F. R. A. N. C. E. S. C. O. Dotta, M. A. R. I. N. A. Ziche, Gian Marco Tosi, A. N. N. A. Girardi, E. R. S. I. L. I. A. Lucenteforte, R. O. S. A. Gini, M. A. H. Y. A. R. Etminan, G. I. A. N. N. I. Virgili
Summary: This study aimed to evaluate the risk of intraocular pressure increase (IOPi) among nondiabetic patients using bevacizumab, aflibercept, and ranibizumab. The results showed that compared with aflibercept, bevacizumab and ranibizumab users had a higher risk of IOPi.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2023)
Review
Medicine, General & Internal
Eugenia Piragine, Davide Petri, Alma Martelli, Vincenzo Calderone, Ersilia Lucenteforte
Summary: Poor adherence to oral antidiabetic drugs (OADs) in patients with type 2 diabetes (T2D) can lead to therapy failure and risk of complications. This study aimed to determine the adherence to OADs in patients with T2D and estimate the association between good adherence and glycemic control. The systematic review and meta-analysis included 156 studies and showed that the proportion of adherent patients was 54%. There was a significant association between good glycemic control and good adherence, indicating that improving adherence could reduce the risk of complications.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Eugenia Piragine, Marco Andrea Malanima, Ersilia Lucenteforte, Alma Martelli, Vincenzo Calderone
Summary: Hydrogen sulfide (H2S) is an endogenous gasotransmitter that plays a role in various biological effects. Imbalanced biosynthesis of H2S has been observed in animal models of age-related diseases, but human studies have inconsistent results. This systematic review and meta-analysis found that circulating levels of H2S were significantly reduced in patients with progressive, chronic, and degenerative diseases compared to healthy individuals. Stratified analysis also showed a significant reduction in circulating H2S levels in patients with vascular disease or kidney disease. These findings suggest that targeting the H2S system may have potential therapeutic benefits for slowing the progression of age-related diseases.
Article
Chemistry, Medicinal
Ersilia Lucenteforte, Marco Finocchietti, Antonio Addis, Mauro Tettamanti, Monica Varano, Mariacristina Parravano, Gianni Virgili
Summary: This study aimed to describe the polytherapy and multimorbidity pattern of patients receiving anti-VEGF and dexamethasone drugs for the treatment of retinal conditions. The results revealed that patients receiving intravitreal injections have a high prevalence of multimorbidity and polytherapy, leading to a significant burden of care.
Article
Medicine, General & Internal
Augusto Azuara-Blanco, John G. Lawrenson, Anthony J. King, Paul J. Foster, Gianni Virgili, Mary Guiney, Winnie Nolan, Anish Jindal, Meenakshi Sharma, Ciaran O'Neill, Christopher R. Cardwell, Mike Clarke
Summary: Angle-closure is a major cause of glaucoma blindness worldwide. This study aims to evaluate the diagnostic performance and cost-effectiveness of two non-contact tests (AS-OCT and gonioscopy) for patients with suspected angle closure.
Article
Ophthalmology
Simone Donati, Chang-Hao Yang, Xun Xu, Marco Mura, Audrey Giocanti-Auregan, Hans Hoerauf, Helmut Allmeier, Tobias Machewitz, Kristian T. Johnson, Elina Santoro, AURIGA study investigators
Summary: The AURIGA study evaluated the use of IVT-AFL in treating DME in routine clinical practice, showing clinically relevant functional and anatomic improvements for up to 24 months. The positive effects of IVT-AFL treatment were largely maintained throughout the study, even with decreasing injection frequency.
OPHTHALMOLOGY AND THERAPY
(2023)
Article
Ophthalmology
Audrey Giocanti-Auregan, Simone Donati, Hans Hoerauf, Helmut Allmeier, Kay D. Rittenhouse, Tobias Machewitz, Chang-Hao Yang, AURIGA Study Investigators
Summary: The AURIGA study showed that patients with RVO experienced clinically relevant functional and anatomic improvements following IVT-AFL treatment in routine clinical practice. These improvements were largely maintained in treatment-naive patients over the 24-month study, suggesting long-term durability of IVT-AFL treatment outcomes.
OPHTHALMOLOGY AND THERAPY
(2023)
Article
Genetics & Heredity
Daniela Dolce, Cristina Fevola, Erica Camera, Tommaso Orioli, Ersilia Lucenteforte, Marco Andrea Malanima, Giovanni Taccetti, Vito Terlizzi
Summary: The sweat test is the gold standard for diagnosing CF, and this study compared the outcomes of CF screening using the Gibson-Cooke and Macroduct methods. The results showed substantial agreement between the two methods in sweat chloride values, except for the CFSPID group, where the result may depend on the method of sweat collection.
INTERNATIONAL JOURNAL OF NEONATAL SCREENING
(2023)
Article
Public, Environmental & Occupational Health
Sabrina Giometto, Marco Finocchietti, Olga Paoletti, Niccolo Lombardi, Maria Grazia Celani, Francesco Sciancalepore, Ersilia Lucenteforte, Ursula Kirchmayer
Summary: The study evaluated adherence to riluzole in ALS patients during the first year of use and identified two main clusters: adherent patients and patients who discontinued therapy. Most patients adhered to therapy, with early therapy discontinuation associated with greater fragility and mortality.
PHARMACOEPIDEMIOLOGY AND DRUG SAFETY
(2023)