Article
Multidisciplinary Sciences
Kai Song, Chao Liu, Jiashuai Zhang, Yang Yao, Huiting Xiao, Rongqiang Yuan, Keru Li, Jia Yang, Wenyuan Zhao, Yanqiao Zhang
Summary: This study identified 12 functional miRNAs associated with metabolic colorectal cancer (CRC) and revealed the important role of miR-20a in promoting the progression of metabolic CRC by regulating fatty acid metabolism. The study suggests that miR-20a could be a potential therapeutic target for preventing tumor metastasis in CRC.
Review
Cell Biology
Wei Huang, Xiaoyue Wu, Shuaixi Xiang, Mingxin Qiao, Xiao Cen, Xuefeng Pan, Xinqi Huang, Zhihe Zhao
Summary: MicroRNAs (miRNAs) are important non-coding RNA molecules that play a critical role in cancer diagnosis, prognosis, and treatment. miR-20a-5p has been found to have anti-cancer effects in various types of cancer, making it a significant biomarker for cancer diagnosis. This paper reviews and summarizes the expression differences of miR-20a-5p in cancer, the changes of miR-20a-5p networks, and the mechanism by which it regulates downstream gene expression. Based on these findings, miR-20a-5p is believed to be a promising and effective marker for cancer diagnosis, prognosis, and treatment.
CELL DEATH DISCOVERY
(2022)
Article
Biology
Joshua D. Greenlee, Maria Lopez-Cavestany, Nerymar Ortiz-Otero, Kevin Liu, Tejas Subramanian, Burt Cagir, Michael R. King
Summary: This study demonstrates that oxaliplatin-resistant CRC cells become more sensitive to TRAIL-mediated apoptosis due to increased DR4 expression, palmitoylation, and translocation. The alteration of DR4/raft colocalization and TRAIL sensitivity by raft perturbation via nystatin and resveratrol is significant. Additionally, treatment with TRAIL liposomes in blood samples from metastatic CRC patients results in a reduction of viable CTCs, with increased DR4/lipid raft colocalization corresponding to increased oxaliplatin resistance and efficacy of TRAIL liposomes.
Article
Cell Biology
Emir Bozkurt, Heiko Dussmann, Manuela Salvucci, Brenton L. Cavanagh, Sandra Van Schaeybroeck, Daniel B. Longley, Seamus J. Martin, Jochen H. M. Prehn
Summary: The study reveals that TRAIL signaling not only activates apoptosis in colon cancer cells but also induces entosis through TRAIL receptors and the structural presence of caspase-8. The association of TRAIL signaling with cell-in-cell structures is significant in colorectal cancer, especially in the context of patient prognosis. Factors controlling entosis in tumors remain to be elucidated despite the evidence of entosis in cancers.
JOURNAL OF CELL BIOLOGY
(2021)
Article
Cell Biology
Valeria Coppola, Ilaria Marino, Uwe Warnken, Mario Falchi, Luca Pasquini, Mauro Biffoni, Ruggero De Maria, Tobias Longin Haas
Summary: We have identified FYCO1 as a protein that promotes the transport of autophagic and endosomal vesicles. It interacts with activated CASP8 and its loss leads to increased sensitivity of cells to apoptosis and impaired transport of TNFRSF10B/TRAIL-R2/DR5.
Article
Cell Biology
Oliver H. Voss, Daniel Arango, Justin C. Tossey, Miguel A. Villalona Calero, Andrea Doseff
Summary: Apigenin sensitizes primary lung cancer cells to TRAIL-induced apoptosis through reprogramming alternative splicing of key TRAIL/DISC components and directly binding heat shock protein 70 to promote cell death. These findings emphasize the synergies between diet and cancer treatments, providing new avenues for improved cancer therapies.
CELL DEATH & DISEASE
(2021)
Article
Medicine, Research & Experimental
Federica Laudisi, Teresa Pacifico, Claudia Maresca, Anderson Luiz-Ferreira, Sara Antonelli, Angela Ortenzi, Alfredo Colantoni, Antonio Di Grazia, Eleonora Franze, Marco Colella, Davide Di Fusco, Giuseppe S. Sica, Ivan Monteleone, Giovanni Monteleone, Carmine Stolfi
Summary: Colorectal cancer is a major cause of cancer-related death, and current treatments are not effective against advanced disease. Researchers have found that the anthelmintic drug rafoxanide can enhance the sensitivity of colorectal cancer cells to TRAIL, a targeted therapy. This discovery suggests that rafoxanide could be a potential treatment option for overcoming TRAIL resistance in colorectal cancer.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Biochemistry & Molecular Biology
Anderson Luiz-Ferreira, Teresa Pacifico, Alefe Cardoso Cruz, Federica Laudisi, Giovanni Monteleone, Carmine Stolfi
Summary: TRAIL is a promising anticancer agent that selectively induces apoptosis in transformed cells, while flavonoids, natural compounds found in plants, have shown competence in enhancing TRAIL-induced apoptosis. However, bioavailability issues are the main limitations for the clinical use of flavonoids.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Xiaomin Qin, Min Zhou, Huabing Lv, Xiaogang Mao, Xianxian Li, Hong Guo, Lin Li, Hui Xing
Summary: The study reveals that LINC00657 suppresses cervical cancer progression by inducing NK cell tolerance through regulating the miR-20a-5p/RUNX3/DR5 axis. LINC00657 acts as a tumor-suppressor by inhibiting cervical cancer cell growth and invasion.
Article
Oncology
Xiaozhou Zhang, Xiaojian Zhang, Qian Jia, Hongqiang Li, Runsheng Ma, Guang Yang, Fengyan Yin, Nannan Jiang, Detao Yin
Summary: The study found that CALML3-AS1 expression was significantly downregulated in PTC, while miR-20a-5p was increased. Overexpression of CALML3-AS1 inhibited PTC cell proliferation by sponging miR-20a-5p and suppressing RBM38 expression. Targeting CALML3-AS1/miR-20a-5p/RBM38 axis may represent a novel therapeutic strategy in the treatment of PTC.
Article
Biochemistry & Molecular Biology
Deepika Raman, Patricia Tay, Jayshree L. Hirpara, Dan Liu, Shazib Pervaiz
Summary: The study shows that TRAIL can induce apoptosis in nasopharyngeal cancer cell lines by activating caspase-3, with the membrane protein TMTC2 playing a crucial role in this process. Patients with high TMTC2 expression have significantly improved disease-free survival, suggesting TMTC2 may serve as a biomarker for TRAIL sensitivity.
Article
Oncology
Wenwen Han, Xiangzhen Bu, Yanli Liu, Fang Liu, Yujie Ren, Yongsheng Cui, Shuhong Kong
Summary: High levels of serum miR-135 and miR-20a were found in patients with GC, with significant differences compared to the non-GC group and healthy control group. The combined detection of miR-135 and miR-20a with MDCT showed higher sensitivity and specificity in diagnosing GC than single detection methods. This multi-detector approach improved the accuracy of GC diagnosis and is valuable in clinical practice.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2021)
Article
Multidisciplinary Sciences
Hallgeir Selven, Sigve Andersen, Mona Pedersen, Ana Paola Giometti Lombardi, Lill-Tove Rasmussen Busund, Thomas Karsten Kilvaer
Summary: This study investigated the prognostic impact of miR-17-5p and miR-20a-5p in colon cancer. The results showed that high expression of both miR-17-5p and miR-20a-5p is associated with a favorable prognosis and inhibits cell migration.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Ying He, Hui Ma, Jing Wang, Yanhua Kang, Qianlong Xue
Summary: This study revealed that miR-20a-5p expression is significantly associated with the clinicopathological characteristics of patients with endometrial cancer (EC). Additionally, Jak1 was identified as a new direct target of miR-20a-5p, and its overexpression could reverse the effects of miR-20a-5p on EC cell proliferation, invasive ability, and adhesion. These findings suggest that miR-20a-5p may act as a tumor suppressor in EC by targeting Jak1, indicating their potential as therapeutic targets in EC treatment.
Article
Dentistry, Oral Surgery & Medicine
Xuefeng Pan, Xinqi Huang, Bo Zhang, Fang Pei, Zhihe Zhao, Xiao Cen
Summary: The study found that miR-20a-5p inhibits the chondrogenic differentiation of hDPSCs by repressing the expression of SMAD6 and activating the NF-kappa B signaling pathway. Knocking down miR-20a-5p promotes cartilage regeneration in osteochondral defects.